"Chemotherapy agents" refers to medications or drugs that are used to treat cancer. These drugs are specifically designed to target and kill cancer cells, helping to slow down or stop the growth of tumors.
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It is also used in some cancers at much higher doses where the side effects are substantial and similar to
other chemotherapy agents.
The research team incorporated dye molecules into the self - assembled nanoparticles to simulate what might be done to incorporate and then
release chemotherapy agents.
Currently, if breast cancer cells develop resistance to these therapies, patients are usually treated with
toxic chemotherapy agents that have significant side effects.
By offering
toxic chemotherapy agents and cancer - causing radiation, Western medicine refuses to look at the true cause of cancer.
As recently as 2016, when patients with advanced bladder cancer were too medically frail to take the standard - of - care
chemotherapy agent cisplatin, oncologists had no effective alternatives to offer.
Current antifungals also have a narrow spectrum of activity, and some interact with other drugs such
as chemotherapy agents and immunosuppressants.»
Researchers led by Patricia Donahoe and Xiaolong Wei of Massachusetts General Hospital and Harvard Medical School found that the common
chemotherapy agent doxorubicin actually encourages the growth of ovarian cancer stem cells.
These drugs include radioactive drugs used for some diagnostic tests like Gallium - 67, Copper 64, Indium 111, Iodine 123, Iodine125, Iodine - 131, radioactive sodium, or Technetium - 99m, antimetabolites, and a few
cancer chemotherapy agents.
There are more than 100
chemotherapy agents in wide use, but oncologists have very little information to guide their decisions about which of these drugs to use in a given patient.
Typical products in this area are prescription medicines for everything ranging
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In future, Bandyopadhyay says, better understanding
how chemotherapy agents impact specific biological pathways should allow drug trials to focus on patients who are more likely to respond to the drugs being tested and enable clinicians to identify targeted or combination therapies for patients with a genetic predisposition to resistance.
In the future, Bandyopadhyay says, better understanding how
chemotherapy agents impact specific biological pathways should allow drug trials to focus on patients who are more likely to respond to the drugs being tested and enable clinicians to identify targeted or combination therapies for patients with a genetic predisposition to resistance.
When used alongside
standard chemotherapy agents daunorubicin and cytarabine in a treatment - resistant AML model, 99.7 percent of cancer cells were killed.
Researchers used the mice to show that pemetrexed and gemcitabine worked against human group 3 tumors and that the drugs could be used in combination with
existing chemotherapy agents to boost treatment effectiveness without undue risk.
Typical doses of a variety of medications will cause reactions in dogs with two copies of the mutation, but some drugs — most notably
several chemotherapy agents — can cause reactions in dogs with only one.
«We found very high response rates to this treatment combination, which has the added benefit of having a much reduced risk of long - term organ damage compared to the highly toxic
chemotherapy agents typically used for patients with relapsed Hodgkin lymphoma,» says Dr. Kelly, who is Program Director of the Pediatric Hematology / Oncology Service Line at the Women & Children's Hospital of Buffalo and holds an additional faculty appointment with the University at Buffalo.
The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to
different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.
Conventional chemotherapy agents work by indiscriminately poisoning and killing rapidly - dividing cells, including cancer cells, by damaging cellular machinery and DNA.
These observations led her and her colleagues to test whether drugs that spur the immune system to attack cancer cells, such as checkpoint inhibitors like nivolumab, would work well with the
targeted chemotherapy agent brentuximab vedotin.
Kvansakul found that the viral protein blocks multiple pro-apoptotic proteins in host cells, and that in a mouse model of Burkitt lymphoma it also
renders chemotherapy agents ineffective, making it a potent oncogene.
Standard
chemotherapy agents don't work specifically on blocking retinoblastoma tumors but instead broadly inhibit DNA replication.
The project, done in collaboration with a medical researcher, delved into O (6)- alkylguanine - DNA alkyltransferase (AGT), a DNA repair protein that is hijacked by cancer cells as a way to resist DNA -
damaging chemotherapy agents.
Purpose of Study: This clinical trial assessed the safety and effectiveness of three newly
developed chemotherapy agents (indenoisoquinolines) when given to dogs with lymphoma.
This is true for many other drugs as well, even including
many chemotherapy agents like doxorubicin and vincristine, and cardiac drugs such as digoxin and corticosteroids.
Pharm Tech will be responsible for prescription preparation to include but not limited to; filling outpatient prescriptions, cart fill, compounding, IV admixture, which may include
preparing chemotherapy agents.
These include radioactive drugs used for some diagnostic tests like Gallium - 69, Iodine - 125, Iodine - 131, or Technetium - 99m, antimetabolites, and a few
cancer chemotherapy agents.
According to the study authors, the results are especially impressive because half of the patients had just finished treatment with the standard class
of chemotherapy agents — fluoropyrimidines (e.g. 5 - fluorouracil [5 - FU] or capecitabine [Xeloda]-RRB- but had failed to benefit from them.
The introduction of nanocarriers as delivery vehicles for
common chemotherapy agents such as the drug irinotecan, has led to improved survival of patients with this disease.
Like Doxil, all other existing cancer nanomedicines use specially engineered nanoparticles to transport an
existing chemotherapy agent.
Using an RNA interference screen, Swanton and his colleagues identified a set of genes involved in the regulation of mitotic arrest and in the metabolism of ceramides, lipid molecules abundant in cell membranes that influence whether tumors are sensitive to
certain chemotherapy agents.