Sentences with word «chloroquine»

This study forms a new rationale for the use of chloroquine in anti-cancer treatment.

In collaborating with the Houston Methodist Cancer Center, they identified the anti-malarial drug chloroquine as a potential cancer stem cell killer.

It is key to its antimalarial property and makes artemisinin - based drugs entirely different from those derived from quinine, such as chloroquine, to which malarial parasites have become resistant.

Doctors recommend malaria prophylaxis with chloroquine if you're visiting the provinces of Alajuela, Limon, Guanacaste, and Heredia.

Disadvantages do not outweigh the benefits — the impact of this study on the use of chloroquine in anti-cancer treatment

Without immediate action, they said, artemisinin resistance would follow the arc of chloroquine resistance, race westward through Myanmar into Bangladesh and India, and ultimately into Africa, destroying all the gains of the past decade.

«Following six decades of chloroquine use, the absence of mutant parasites genetically resistant to this drug is intriguing.

Treatments include chloroquine and artemisin, but the parasite is becoming more resistant to these drugs.

I recently recalled that little girl and countless other children saved from certain death by chloroquine because I was reading about 80 U.S. Marines struck with falciparum malaria a few weeks after deploying to Liberia in August 2003.

The drug, called chloroquine, has a long history of safe use during pregnancy, and is relatively inexpensive.

Or people would take a few tablets of chloroquine for protection before entering the forest and then pocket the rest.

«Although chloroquine didn't completely clear Zika from infected mice it did reduce the viral load, suggesting it could limit the neurological damage found in newborns infected by the virus.»

On top of that, chloroquine does not take effect in the liver — so it is unable to prevent the parasite from reproducing.

This work reinforces a previous study, published in Nature Scientific Reports last November, that shows the anti-malaria drug chloroquine reduces Zika transmission between mothers and babies in a mouse model.

«In the 1950's, the Brazilian health agencies added chloroquine into cooking salt and distributed it to the population in endemic areas as an effective way of spreading the inexpensive anti-malarial drug as a prophylactic on a wide scale.

«Malaria medicine chloroquine inhibits tumor growth, metastases, study shows.»

With a view to clinical studies (tests on humans) it is important to note that the effects on the tumor vasculature were even observed at chloroquine concentrations that had little effect on autophagy in the cancer cells.

The anti-cancer effect of the antimalarial agent chloroquine when combined with conventional chemotherapy has been well documented in experimental animal models.

The professor and his colleagues demonstrated in their study that while resistance to drugs like chloroquine, which works to slow the growth of malaria, has been explored, an explanation of the resistance to the cell - destroying effects of the medication has not been fully understood.

By now, some parasites have evolved resistance to the drug: genetic adaptations that allow them to expel chloroquine from their food vacuoles 40 to 50 times faster than their drug - sensitive kin.

Remarkably, investigators at the Radboud University Nijmegen Medical Centre (RUNMC) in The Netherlands have shown that long - term sterile immunity (at least 28 months) to experimental P. falciparum - infection can be induced by exposing malaria - naïve volunteers to the bites of 15 P. falciparum - infected mosquitoes monthly for three months while on chloroquine prophylaxis (CPS immunization).

Within 20 years, mass chloroquine treatment, along with DDT spraying and other antimosquito measures, removed the threat of disease from more than 500 million people living in formerly malaria - ridden areas.

Pregnant mice received chloroquine through drinking water in dosages equivalent to acceptable levels used in humans.

After all, unlike chloroquine, which fails to kill resistant parasites, artemisinin still worked, just more slowly.

Resistance to chloroquine surfaced here in the 1950s before sweeping through the wider Mekong region and then into India and Africa, causing millions of deaths.

To date, it was assumed that chloroquine increases the sensitivity of cancer cells to chemotherapy by means of a direct effect on the cancer cells.

Chloroquine blocks autophagy, a process that cancer cells use to survive to anti-cancer treatments.

Hannelore Maes from the team of Patrizia Agostinis (KU Leuven), together with Anna Kuchnio from the team of Peter Carmeliet (VIB - KU Leuven) have started a study to explain how chloroquine can strengthen the effect of anti-cancer treatments.

However, a recent study by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors.

They also aim to design better drugs for the disease by modifying Chloroquine and Amodiaquine.

All she needed was for Dr. Hodges to snake a bitter dose of chloroquine down her throat.

Chloroquine costs just 10 cents a course.

Chloroquine production geared up too late for the drug to save lives during campaigns in the notoriously malarial Pacific and the Mediterranean.

Whether chloroquine - resistance reversers will someday be safe and feasible treatments is still a question.

Chloroquine controls the parasites by interrupting this heme detoxification step, exposing them to their own poisonous by - products.

The researchers say such «hypopigmentation» occurs because chloroquine poisons pigment - producing cells in hair follicles.

The researchers presented artificial prey to birds called great tits: hollow stalks of rye filled with fat, some of which were mixed with bitter chloroquine.

Scientists had thought that histamine signals traveled through one type of calcium channel, while chloroquine signals traveled through a different channel.

Led by Mauro Ferrari, Ph.D., president and CEO of the Houston Methodist Research Institute, and Joy Wolfram, Ph.D. (now at Mayo Clinic's campus in Jacksonville, Florida), the research showed that chloroquine interfered with immune cells called macrophages, which are used by the body to identify microscopic foreign objects and destroy them.

Chloroquine decreased the macrophages» ability to clean up the nanoparticles.

Chloroquine offers a number of advantages.

Chloroquine potentiates the anti-cancer effect of 5 - fluorouracil on colon cancer cells.

Resistance to other malaria drugs, namely chloroquine and sulfadoxine / pyrimethamine, first developed in Southeast Asia before spreading to Africa.

A small tweak in the crt gene, and P. falciparum can suddenly pump chloroquine out of its cells.

Instead, many people end up with less expensive but ineffective drugs such as chloroquine and artemisinin monotherapies, which increase the risk of drug resistance.

For reasons still unclear, resistance to older malaria drugs — including chloroquine and sulfadoxine - pyrimethamine — emerged in Pailin as well and then spread broadly, Plowe points out.