Sentences with word «chondrogenesis»
Comparison of chondrogenesis in static and dynamic environments using a SFF designed and fabricated PCL - PEO scaffold.
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Project Associate Professor Shinsuke Ohba at the Department of Bioengineering, the University of Tokyo Graduate School of Engineering, identified two genome - wide modes (Class I and Class II engagement) of Sox9 action in transcription during chondrogenesis.
In vitro chondrogenesis assays demonstrated that the R206H ACVR1 mutation can stimulate progenitor cells to differentiate to cartilage in concert with the appropriate cell environment and differentiation factors and that this mutant receptor activates BMP signaling constitutively without BMP stimulation.
By contrast, the R206H ACVR1 mutant only slightly enhances the expression of initial and early chondrogenesis markers (collagen type II and aggrecan), consistent with a milder stimulatory effect of the FOP ACVR1 mutation on chondrocyte differentiation.
This mechanism might account for the extent of tissue damage upon stress but also contributes to normal chondrogenesis by regulating chondroblast expansion.
Research Paper MicroRNA - 193b - 3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3 Fangang Meng, Zhiwen Li, Zhiqi Zhang, Zibo Yang, Yan Kang, Xiaoyi Zhao, Dianbo Long, Shu Hu, Minghui Gu, Suiwen He, Peihui Wu, Zongkun Chang, Aishan He, Weiming Liao Theranostics 2018; 8 (10): 2862 - 2883.
Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.
In vivo mesenchymal cell recruitment by a scaffold loaded with transforming growth factor β1 and the potential for in situ chondrogenesis.
In addition to these applications, new uses may be developing; these involve the transfer of genes with the potential of increasing efficacy â $» for example, the transduction of mesenchymal stem cells with transforming growth factor Î ² 1 to allow chondrogenesis to occur in vitro before the cells are used clinically.
What MSC - secreted factors are important for chondrogenesis and can we use this information to create a stem cell - free therapy?
Although the mechanisms underlying Sox9 - mediated transcriptional regulation during chondrogenesis have been intensively investigated at a certain genomic region, its genome - wide regulation remained unclear.
Cartilage formation (chondrogenesis) requires the normal function of Sox9, a protein that regulates the expression of chondrogenesis - related genes.
Interestingly, these enhancers overlap in activity during sequential stages of chondrogenesis and appear to be controlled by distinct mechanisms.
A main, novel finding is that most genes that are critical in chondrogenesis are under the control of super-enhancers, that is, clusters of enhancers.
The 3D structure of the pellet mimics embryonic development of the limbs, and improves the intercellular communication essential for chondrogenesis to occur [8, 9].
At puberty, oestrogen promotes skeletal maturation and the gradual, progressive closure of the epiphyseal growth plate, possibly as a consequence of both oestrogen - induced vascular and osteoplastic invasion and the termination of chondrogenesis.