Sentences with word «clonal»

The presence of clonal expansions of such virus - specific cells may shrink the available repertoire for other antigens and contribute to the increased incidence of infectious disease in the elderly.

T and B cell clonal expansion in Ras associated lymphoproliferative disease (RALD) as revealed by next generation sequencing

Using spatial correlation functions to quantify the differences between emergent cell lineage segregation patterns, we find that strong adhesion often, but not always, maximizes the size of clonal cell clusters on flat surfaces.

Postdoctoral researcher in Genomics / Computational Biology The available postdoctoral position concerns developing and applying novel genomic and computational approaches to study non-genetic heterogeneity in clonal population of Read more about Postdoctoral position in RNA Genomics & Computational Biology -LSB-...]

The LymphoTrack MRD software enables temporal tracking of clonal populations, and has demonstrated potential to improve subject monitoring in clinical trial and research settings.

The Cancer Genome Project uses high - throughput genome sequencing to identify these somatically acquired mutations with the aim of characterising cancer genes, mutational processes and patterns of clonal evolution in human tumours.

When plated as single cells in wells of a 96 - well plate, at least 50 % of those seeded cells will proliferate into clonal colonies.

Single - cell seeding of edited hiPS cells in this system results in high survival of pluripotent, edited clones, yielding a diverse set of edited clonal lines.

There were the obvious differences between the wines arising from clonal selection (most were made from the ubiquitous Gingin or Mendoza clone of chardonnay, which first arrived in WA in the early»70s, but a couple were made from more recently imported French clones), vintage variation and sub-regional influence (wines from the cooler south of Margaret River tended to be leaner and crisper than those from the warmer north).

Therefore, tests that detect TRB clonal rearrangements can be useful in the study of B - and T - cell malignancies.

Hyo - eun, C. Bhang, et al. «Studying clonal dynamics in response to cancer therapy using high - complexity barcoding.»

We also observed that single cells from either the V+S + or V − S + fractions were both equally effective at generating clonal cultures with the normal range of Venus expression and in no cases did V+S + cells give rise to differentiated colonies.

Performs genome - wide profiling of vector integration sites as readout of cell growth at clonal level, in basic research studies and technology development, in preclinical safety studies and in gene therapy treated patients.

One factor that could contribute to this trend is that blood stem cells from older donors are more prone to inflammation, produce more myeloid cells and fewer lymphocytes, and are more likely to be affected by clonal hematopoiesis, a mutation of blood cells that can increase the risk of blood cancer and overall mortality.

In this study, we analyzed the CD8 clonal composition of nonagenarians and middle - aged individuals.

Dr Ignacio Vazquez - Garcia, the first author from the Wellcome Trust Sanger Institute and University of Cambridge, said: «We found that the degree of diversity within the cell population — known as clonal heterogeneity — played a major role in the acquisition of antimicrobial resistance.

«The finding that metastases are frequently polyclonal and that subsequent cellular behavior is site - dependent also gives us insight into the origins and evolution of clonal diversity in metastatic disease.»

So, why are we not surrounded by clonal organisms?

The macrophages release cytokines that can activate more innate immune cells, readying them for attack on viruses or cancer cells, or they can activate the adaptive arm of immunity, priming it for clonal expansion.

However, only one lineage (type II) is widespread and predominates in the global populations, a phenomenon known as clonal expansion.

Our LymphoTrack (RUO) and LymphoTrack Dx (CE - IVD) Assays are used to identify and track clonal B - and T - cell populations.

Pluripotency was maintained in all edited clonal lines, as evidenced by the persistent expression of the three pluripotency markers.

Novel method to identify source - associated phylogenetic clustering shows that Listeria monocytogenes includes niche - adapted clonal groups with distinct ecological preferences.

Included with the assay is specialized bioinformatics software that allows researchers and pharmaceutical companies conducting clinical trials, to identify and track clonal populations by performing minimal residual disease (MRD) testing of subsequent samples.

Once the Cas9 - sgRNA ribonucleoprotein (RNP) complexes have been delivered, single cells must be isolated and expanded into clonal cell lines to isolate and screen for the genotype of interest.

The largest clonal tree colony called Pando, also known as The Trembling Giant, shares one massive underground root system and is estimated to be 80,000 years old.

Some plants, such as clonal plants, can exhibit avoidance behavior as a third response type: they grow away from their neighbors.

Clonal persistent patients harbored a larger number of residual tumor cells with genotypes and phenotypes that were altered in response to NAC.»

However, since the ELISPOTS were nearly identical to our controls, they support lack of clonal deletion of alloreactive T cells.

They also include a comprehensive bioinformatics package, enabling you to identify the DNA sequence, clonal prevalence, and V - J family identity for each gene rearrangement.

For samples containing TRB clonal populations, the yield is up to four prominent amplified products of the same length and sequence that are detected with significant frequency of occurrence, within a diminished polyclonal background amplified at a lower frequency.

Laboratories can now identify clonal rearrangements associated with hematologic malignancies and track those clones for MRD in their own facility.

Our NGS kits are used to detect clonal gene rearrangements, somatic hypermutations and for the study of MRD.

S1B) prostate cancer cells were cultured at clonal densities, in ∼ 2 weeks clones resembling keratinocyte holoclones, meroclones, and paraclones could be easily identified.

Through a process called clonal evolution, tumor cells acquire mutations and undergo natural selection for growth advantages.

Infant T cell repertoire analysis combines quantitative PCR to determine relative frequency of T cell receptor chain families with deep sequencing (LINK TO URI GSC) of the CDR3 region to evaluate clonal diversity within each family.

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

The article Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization was published in the journal Nature Communications on September 6, 2016.

In these cases, UroSEEK could be detecting clonal proliferations in the bladder epithelium that did not progress to cancer, and such proliferations may be more common in patients with BC than in the general population Risques and Kennedy, 2018Because only one biopsy from the primary tumor was available for comparison, it is also possible that intratumoral heterogeneity explains some of the discrepancies.

Error bars (see supplementary data) represent standard deviation between expression levels in independent clonal lines of HV cells.

Through clonal analyses, serial passaging in vitro, serial tumor transplantation experiments, replating assays, and immunophenotyping, we provide unequivocal evidence that PC3 prostate cancer cell holoclones contain self - renewing cancer cells that could initiate serially transplantable tumors.