Sentences with phrase «cytotoxic effects»
"Cytotoxic effects" refers to the harmful impact of a substance or agent on cells. It means that the substance has the ability to damage or kill cells in the body, which can lead to various health problems. Full definition
Thus, the molecule's observed «effect» on cell growth is nothing more than the well - known cytotoxic effect of alcohol.
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Curcumin's anticancer effect is attributed to its ability to induce apoptosis in cancer cells without cytotoxic effects on healthy cells.
(26) These studies also show that cadmium reduces insulin levels and has direct cytotoxic effects on the pancreas.
As a result, this system has greater cytotoxic effects against these cells than either of the drugs alone or without the system.
In healthy skin, CD49a + and CD49a cells are dormant, but quickly respond with inflammatory and cytotoxic effects when stimulated by IL - 15, a protein secreted from skin cells as a rapid - response defence against microbial attack.
Therefore, to overcome chemoresistance mediated by EMT, drug screening efforts have focused on eliminating the mesenchymal subpopulation by searching for drugs with preferential cytotoxic effects on mesenchymal, rather than epithelial HMLE subpopulations [7].
15d - PGJ2 induced significant G2 / M arrest, and exerted time - and dose - dependent cytotoxic effects against all OS cell lines.
Our data obtained with the MTT assay suggest a non-specific cytotoxic effect of long term (3 days) treatments of both endothelial and tumor cells with micromolar concentrations of kahweol.
This natural compound is a withanolide, but it's the only one you need to avoid, since it has proven cytotoxic effects.
ONA has the potential to enhance existing anti-cancer drugs while also having little to no cytotoxic effects on normal cells.
Due to this cytotoxic effect, the tumors shrank and the animals lived longer.
ATM and ATR protein kinase activity confers cellular resistance to the cytotoxic effects of the anthelminthic drug niclosamide.
In addition, they have not only the ability to secrete immunosuppressive cytokines that regulate T cell function, but they also have the capacity to suppress the cytotoxic effects of natural killer cells.
The goal was to deepen the knowledge about the pharmacological and cytotoxic effects of the drug Temodex in vitro in different human brain cancer cell lines.
Fibrils did not exert a cytotoxic effect over 72 h of culture.
In all these in vitro assays, kahweol treatments were carried out under conditions (kahweol concentration and duration of treatment) that did produce no cytotoxic effect on cells.
Moreover, ROS generation was found treatment with 15d - PGJ2, and its cytotoxic effect could be reversed with N - acetyl - l - cysteine.
In this study, the cytotoxic effect and mechanism underlying 15d - PGJ2 effects against OS were explored using OS cell lines.
Since amiodarone HCL is known to exert its cytotoxic effect through the extrinsic, caspase - 9 independent apoptotic pathway [33] our microarray results confirm that the differential cytotoxic effect seen in NSCs treated with amiodarone HCL is due to specific activation of extrinsic apoptosis pathways resulting from exposure to the drug.
In addition, the expression of the p53 homolog, p73, is strongly induced by calcitriol and p73 can sensitize tumor cells to the cytotoxic effects of platinum and taxanes.
There is research showing a potentially immunosuppressive and cytotoxic effect of the seeds of the plant, and extracts or supplements that contain the roots, seeds and stems should be avoided for this reason until more research is done.
It does so by producing hydrogen peroxide in cancer cells, which creates oxidative stress forcing the cancer cells to die off (this is known as a cytotoxic effect).
Although no studies have directly confirmed its effect on breast cancer stem cells thus far, the outlook is positive that one day the connection may be made considering its cytotoxic effect on breast cancer cells, in general, has already proven to be so high.
Borrego F, Robertson MJ, Ritz J, Pena J, Solana R. CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor.
All extracts were found to have cytotoxic effects on the cancer cells, with the clove essential oil producing the highest cytotoxic effect.
One study examined the cytotoxic effects of different types of clove extract on breast cancer cell lines, including water - based, alcohol - based and essential oil extracts.