Sentences with word «dasatinib»

Researchers found that genetically disrupting this pathway, or using the FDA - approved Src kinase inhibitor dasatinib, increases PUMA levels and decreases tumor progression and metastasis in mice by up to fivefold.

He had no idea whether existing compounds could meet those requirements, but after he presented his work at a meeting, a call came from BMS, leading to a successful collaboration and ultimately to the CML drug dasatinib (Sprycel).

The researchers confirmed these findings in a mammary carcinoma mouse model — treatment with dasatinib just a few days after administering two high doses of chemotherapy prevented tumor growth and increased survival rates.

Researchers at the University of Sheffield investigated a drug called dasatinib, which works by blocking certain chemical signals that stimulate the growth of cancer cells.

«If dasatinib or nilotinib can beat Gleevec in the response they elicit, they will offer patients even greater protection from relapse and possibly even better survival,» he said.

Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates.

In one report, a patient with an L576P KIT mutation in whom imatinib therapy had previously failed experienced marked reduction in tumor burden in response to dasatinib treatment.

«Although TKIs such as the first - generation TKI imatinib mesylate (IM) and the second - generation TKIs dasatinib and nilotinib have markedly improved the prognosis of patients with chronic phase CML, a cure remains elusive.

Because dasatinib is already cleared for clinical use, researchers hope that progress can be made more quickly towards trialling the drug in humans as a treatment for DMD.

In contrast, because of the high incidence of TP53 mutations in the HPV - inactive class, these tumors may be less responsive to the standard cisplatin chemotherapy and more sensitive to other chemotherapies such as dasatinib.»

New inhibitors include dasatinib and nilotinib, which are significantly more potent than imatinib and may overcome resistance.

Several targeted drugs (e.g., imatinib [Gleevec ®], dasatinib [Sprycel ®]-RRB- are effective for treating CML because they attack cells with the Philadelphia chromosome, the genetic abnormality that is the hallmark of this type of leukemia.

A phase I study of dasatinib in children and adolescents with chronic myeloid leukemia (CML) and other malignancies determined dosing for further studies and suggested the drug is well tolerated and effective in these patients.

Those fish treated with dasatinib were able to swim further and for longer than those in a control group.

A drug called dasatinib was found to be safe and effective for children with chronic myeloid leukemia, according to a clinical trial published in the Journal of Clinical Oncology.

This discovery led him to evaluate second generation Abl kinase inhibitors, such as the dual Src / Abl inhibitor dasatinib, which received fast - track approval at the FDA in June 2006.

Treating cells simultaneously with docetaxal and dasatinib or administering dasatinib after a longer period of time did not produce the same effects.

The researchers observed that two drugs each killed a large fraction of the cells that had begun transitioning: dasatinib, a drug that targets the Src Family Kinase (SFK) and RK20449, a new drug in pre-clinical testing that specifically targets one of the SFK proteins called Hck.

Other drugs that work in a similar way to dasatinib are also under investigation by Professor Winder's team.

The trio was integral in developing the drugs imatinib and dasatinib, which shut down certain proteins that are responsible for the rapid division of cancer cells.

During his time at Bristol - Myers Squibb, he facilitated a discovery program ultimately leading to the development and launch of Sprycel ® (dasatinib), a treatment for chronic myeloid leukemia.

Contrary to previous laboratory findings, a new study has shown for the first time the effect of stem cell burden on treatment outcome, discovering that tyrosine kinase inhibitors, including imatinib and dasatinib, can rapidly eradicate most chronic myeloid leukemia stem cells.

& Ham: I imagine that what I assume here to be germline gene therapy is not necessarily needed: if the dasatinib / quercetin combo works in humans like it does in mice the end result should be the same.

PPAM showed synergism with STAT3 inhibitor S3I - 201, glucose hexokinase inhibitor 2 - deoxy - D - glucose (2 - DG) and dasatinib, thus confirming STAT3 pathway and glycolysis / autophagy as targets.

[68] Other KIT inhibitors, such as sorafenib, dasatinib, and sunitinib, have also been reported to have beneficial effects in mucosal melanomas harboring KIT mutations.

The adenosine triphosphate (ATP)-- competitive kinase inhibitors imatinib (STI571; trade name: Gleevec), dasatinib, and nilotinib inhibit multiple tyrosine kinases in addition to ABL1 and ABL2 (5).

Druker said that Gleevec's long - term efficacy also offers a benchmark for comparative testing of two other similar kinase inhibitors, dasatinib and nilotinib, now underway.

He has played a key role in the discovery and development of multiple approved drugs, including imatinib (Gleevec), dasatinib (Sprycel), and enzalutamide (Xtandi).

In September 2017, Canada's Federal Court of Appeal (FCA) released its decision in BMS v Apotex Inc, 2017 FCA 190, reversing the Federal Court's (FC) decision (2017 FC 296) that held BMS's dasatinib (SPRYCEL ®) patent invalid for lacking a demonstration or sound prediction of utility as of the Canadian filing date.