Sentences with phrase «diabetic nephropathy»

He contributes to other large - scale clinical trials including SAVE (evaluating whether treatment of obstructive sleep apnoea with continuous positive airways pressure can reduce the incidence of serious CV events in patients with established CVD), and CREDENCE, a randomised, double - blind, placebo - controlled trial assessing whether canagliflozin can slow the progression of diabetic nephropathy in patients with type 2 diabetes.

I was wondering how you handle patients with diabetic nephropathy with GFRs below 40.

Renal complications, also known as diabetic nephropathy, are one of the most life - threatening complications of diabetes that often lead over time to end - stage renal disease (ESRD).

Flax and Pumpkin seeds mixture ameliorates diabetic nephropathy in rats.

The finding adds further credence to a current pharmaceutical effort to create new treatments for diabetic nephropathy, liver fibrosis and other progressive fibrotic and inflammatory diseases, based on blocking these two molecules, both members of the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX) family of proteins.

Zhang's team focused on two of them, saxagliptin and sitagliptin, along with an antioxidant supplement called α - lipoic acid, which is used to treat diabetic nephropathy, a common complication of the disease.

Taurine is known to have some preventive effects on type 2 diabetes and its complications, but can it also prevent the kidney disease diabetic nephropathy?

Furthermore, targeting this receptor with an available drug called CTLA4 - Ig, or abatacept, helped to maintain kidney function in mice with diabetic nephropathy.

In patients with chronic kidney disease who are not on dialysis, ACEIs and ARBs slow the progression of diabetic nephropathy and reduce cardiovascular risk.

They developed an animal study to test the preventive effect of taurine on the kidney disease known as diabetic nephropathy.

Flax and Pumpkin seeds mixture ameliorates diabetic nephropathy in rats.

The compound is now in phase II clinical trials for diabetic nephropathy and is being explored in other fibrotic diseases.

People with type 1 diabetes may develop problems with their eyes (diabetic retinopathy) and their kidneys (diabetic nephropathy), or existing problems may get worse.

In both cases, left untreated, the extra glucose in the blood can cause blindness, cardiovascular disease, diabetic nephropathy, diabetic neuropathy and death.

«This study shows that a high - risk score for obstructive sleep apnea is common in non-dialysis CKD patients with diabetic nephropathy and is associated with more rapid loss of renal function,» the investigators concluded.

«The next steps will be to test anti-B7-1 drugs in individuals with diabetes and diabetic nephropathy to see if they can abrogate the progression of the disease in humans as well,» said Dr. Fiorina.

Diabetics who develop kidney disease, or diabetic nephropathy, due to high blood glucose levels may eventually require dialysis or a kidney transplant.

Paolo Fiorina, MD, PhD (Boston Children's Hospital / Harvard Medical School) and his colleagues have discovered that a receptor called B7 - 1 is expressed by kidney cells during the progression of diabetic nephropathy.

In an accompanying editorial, Kiran Chandrashekar, MD and Luis Juncos, MD (University of Mississippi) noted that there is a critical need to develop additional therapies to improve the treatment of diabetic nephropathy and that endothelin inhibitors hold considerable promise.

Furthermore, sex - specific differences in gene polymorphism are suggested by one study showing that diabetic women carrying ACE D allele have a higher risk for development of diabetic nephropathy, which was not seen in diabetic men (Table 2)(331).

In contrast, testosterone accelerates the development of nondiabetic chronic renal disease, and in streptozotocin - induced diabetic male rats, decreased testosterone levels and changes of sex hormone levels exacerbated the development of diabetic nephropathy, showing the importance of sex hormones in pathophysiologic mechanisms behind disease progression (334).

Men show faster progression of diabetic nephropathy and more often undergo dialysis therapy (318).

He has made important contributions to the fields of diabetic nephropathy, pregnancy - associated disease, renal vascular hypertension and transplantation.

The results suggest that effective therapeutic agents could be developed to enhance the effects of GLP - 1R on the endothelium which may prevent glomerular endothelial dysfunction and slow the progression of diabetic nephropathy.

Chronic high blood sugar leads to diabetic nephropathy, which causes the kidneys to excrete protein in the urine.

Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy.

A double - blind, randomized, placebo - controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy.

Oxidative stress plays a central role in the pathogenesis and progression of late microangiopathic complications (diabetic nephropathy) in diabetes mellitus.

In this prospective, open and non-randomized study, the effect of alpha - lipoic acid on the progression of endothelial cell damage and the course of diabetic nephropathy, as assessed by measurement of plasma thrombomodulin and urinary albumin concentration (UAC), was evaluated in 84 patients with diabetes mellitus over 18 months.

It is postulated that the significant decrease in plasma thrombomodulin and failure of UAC to increase observed in the alpha - lipoic acid treated group is due to antioxidative effects of alpha - lipoic acid, and if so that oxidative stress plays a central role in the pathogenesis of diabetic nephropathy.

Effect of Alpha - lipoic Acid on the Progression of Endothelial Cell Damage and Albuminuria in Patients with Diabetes Mellitus: An Exploratory Study Diabetes Res Clin Pract 2001 (Jun); 52 (3): 175 — 183 Oxidative stress plays a central role in the pathogenesis and progression of late microangiopathic complications (diabetic nephropathy) in diabetes mellitus.

Kimmelstiel - Wilson disease (also known as diabetic nephropathy, or simple kidney disease) is a kidney disease that makes blood filtration through the kidneys become more difficult.