They offered customers over the age of 35 injections of young plasma — the liquid component of blood that blood banks usually store —
from donors ages 16 to 25.
The authors note that it is the first study to conduct an analysis of the effect of sperm
donor age on live birth using a large national database.
Building on previous studies, the relationship
between donor age and patient survival was shown to be linear.
Inhibition of cell division is also more pronounced
with donor age [8].
«Despite these trends,» said Dr Choudhary, «it's important to note that the impact of
sperm donor age on live birth failed to reach statistical significance in any of the age groups we studied.
V. Lo Sardo et al., «Influence
of donor age on induced pluripotent stem cells,» Nature Biotechnology, doi: 10.1038 / nbt.3749, 2016.
Mehta J, Gordon LI, Tallman MS, et al., Does
younger donor age affect the outcome of reduced - intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies beneficially?
They received either a saline placebo or plasma — blood from which the red cells have been removed — from
blood donors aged 18 — 30.
The HFEA states that centres should normally observe the
relevant donor age limit, but, «due to less substantial evidence on age limits for sperm donors,» centres can assess the possible effect of a donor's age on a case by case basis.
The researchers examined data from the Organ Procurement and Transplantation Network (OPTN) / United Network for Organ Sharing (UNOS), the nation's organ transplant network, on all reported «eligible deaths,» — defined as potential brain - dead
organ donors age 70 years or less without any medical conditions precluding donation — from 2008 to 2013.
Scientists at the University Autònoma de Barcelona in Spain studied 200,000 sperm from 18
healthy donors aged 24 to 74 years.
Ali Torkamani, Kristin Baldwin, and their colleagues at the Scripps Research Institute in California have found that iPSC genomes have methylation patterns that
reflect donor age.
JR is one of about 100 people who have each paid $ 8000 to join a controversial trial, offering them infusions of blood plasma
from donors aged between 16 and 25 in a bid to turn back the clock.
In general, the number of mutations those pluripotent cells carry increases
with donor age — until around age 90, that is, when the number of mutations decreases, the researchers found.
«Researchers find association
between donor age, female sex and transfusion outcomes.»
Indeed, this trend of less likelihood of live birth with younger
sperm donor age might simply be explained by the fact that younger men who donate sperm are less likely to have proven fertility themselves than older sperm donors with proven fertility.»
Kollman C, Howe CW, Anasetti C, et al., Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect
of donor age.
Current UK guidelines, for example, recommend that sperm should not be taken from
donors aged 41 or over.
* in the older IVF patients LBR was 11 % with a donor under the age of 20, 17 % with
donor aged 26 - 30, and 16.6 % with a donor aged 41 - 45
A total of 70 DCD liver transplants were performed at the investigators» institution: 32 from
donors aged 55 years and younger, 20 from donors between 56 and 69 years, and 18 from donors aged 70 years and older.
«The neurons we derived showed differences depending on
donor age,» says Mertens.
In addition, recipients of red blood cells from
donors aged 20 - 30 were associated with a six percent increased risk of death per transfused product compared with recipients of red blood cells from donors aged 40 - 50.
Recipients of blood from
donors aged 17 - 20 were associated with an eight percent increased risk of death per unit transfused compared with recipients of red blood cells from donors aged 40 - 50.
Overall, the number of iPSC mutations — which the researchers suspect were present but undetected in donor blood cells — increased linearly with
donor age.