Sentences with phrase «gene conversion»
Gene conversion is a process in which genetic information is copied or switched between two similar genes, resulting in changes in their sequences. It is like a genetic "spell-check" that fixes mistakes, but it can also lead to genetic variations and diversity. Full definition
Targeted repair in stem cells The laboratory co-ordinates a EU network «Therapeutic in vivo DNA repair by site - specific double - strand breaks» that propose to develop a generally applicable technology that should allow high efficiency targeted gene conversion in vivo.
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Comparisons with the chimpanzee genome indicate that human SIGLEC11 emerged through human - specific gene conversion by an adjacent pseudogene.
Unambiguous identification of exon 14 deletion in patients with suspicious Lynch syndrome reflects the main advantage of this approach, since traditional molecular methods can not distinguish the deletion of the active gene from that of the pseudogene due to frequent gene conversion between these highly homologous sequences.»
The rate of meiotic gene conversion varies by sex and age.
For instance, Amrose could be cloned into the Ig locus together with other far - red proteins as potential gene conversion donor sequences to further improve or diversify Amrose's properties.
The DT40 evolution platform also supports using gene conversion competent cells and homologous donor sequences as «pseudo genes» to evolve proteins of interest [24]--[25].
When parts of chromosomes broken and exchanged, errors can sometimes occur during their repair due to a process called «GC - biased gene conversion,» says Matthew Webster.
A strong, male - biased mutation spectrum was also measured, wherein three - quarters of mutations occurred in sperm thorough spermatogenesis, as well as new structural alterations, such as changes in gene conversion and copy number.
Gantz and Bier showed in their experiments, which were conducted in a biosafety laboratory with a high - level of containment to prevent the accidental release of any deleterious mutant genotypes, that propagation of an MCR mutation in flies is remarkably efficient, with a gene conversion rate of about 95 percent.
More specifically, rabbits have two antibodies in affinity maturation mechanisms: gene conversion and hypermutation, as opposed to mice where no gene conversion occurs.
Alu elements affect the genome in several ways, causing insertion mutations, recombination between elements, gene conversion and alterations in gene expression.
Characterized the role of biased gene conversion, a non-adaptive recombination associated process, in shaping the fastest evolving regions of the human genome.
Biased gene conversion and GC - content evolution in the coding sequences of reptiles and vertebrates.
Generally, this occurs because a position that is heterozygous in the germline is affected by some kind of structural event — deletion, gene conversion, chromosome loss, etc. — that results in the loss of one allele.
Developing B cells activate and diversify their immunoglobulin (Ig) genes by recombination, gene conversion (GC) and somatic hypermutation (SHM).