Sentences with phrase «gene networks»

But identifying gene networks like these is only the beginning.

By searching for gene networks with mutations in multiple different genes, his team aims to discover new ways to treat disease.

We are particularly interested in how cells use gene networks to make robust decisions even in the presence of significant fluctuations in gene expression.

The researchers examined gene network expressions changes to determine the effects of vacation and meditation.

A basic understanding on the set of genes and gene networks responsible from directly regulating lifespan and the mechanisms used in this regulation is also missing.

My group studies how the resulting gene networks function and how they can be compromised in human disease.

Examples of gene networks in the hippocampus affected by brain trauma.

Using a reverse ‐ engineered analysis of gene networks involved in malignant transformation of prostate cancer cells coupled with expression (transcription) profiling, these investigators computed the likelihood that genes within the network and associated pathways mediate disease pathogenesis.

Using cutting - edge technologies, the team of collaborators from Wyss, Massachusetts Institute of Technology, Boston University, Arizona State University, Cornell University, University of Wisconsin - Madison, Broad Institute, and the University of Toronto have developed a cell - free, paper - based platform that can host synthetic gene networks for use outside of the lab.

«We're looking at the genes and gene networks involved in stem cell proliferation, meristem development and flowering and branching,» said Van Eck, «with the end goal being that maybe genes that we identify in tomato, which is strictly being used as a model, might help us understand what can be done to increase yield in other crops.»

A systems biology approach integrating genome ‐ wide genetic variation and transcriptome profiling data from participants of the Framingham Heart Study identifies key regulatory genes and gene networks underlying blood pressure control.

Each bacterium in the colony communicates via chemical «tweets» and performs a sophisticated decision - making process using a specialized complex gene network composed of many genes connected via complex circuitry.

By analyzing the role of PPARγ in dendritic cells using molecular, genomic, and pharmacologic approaches, we identified genes and gene networks regulated by this receptor.

According to Lu, this work advances the quantitative understanding of gene circuit behaviors, and facilitates the transformation of gene network design from trial - and - error construction to rational forward engineering.

Now researchers at UC San Francisco have taken the first step towards a comprehensive atlas of gene expression in cells across the developing human brain, making available new insights into how specific cells and gene networks contribute to building this most complex of organs, and serving as a resource for researchers around the world to study the interplay between these genetic programs and neurodevelopmental disorders such as autism, intellectual disability, and schizophrenia.

«The lessons we learned about cardiac gene networks from this family and their mutation will inform the development of treatments not only for their form of heart disease, but for many others.»

Nevertheless, the non-electrophilic character of HPP - 4382 and the fact that an intact heme binding site in Bach1 is required for modulation of Bach1 activity indicates that HPP - 4382 represents a first - in - class compound that is able to activate the anti-oxidant response gene network by specific modulation of Bach1 activity.

Biologists could use an infusion of mathematics as well, says Iya Khalil, vice president of R&D at Gene Network Sciences Inc. in Ithaca, New York.

«New epilepsy gene network identified by scientists.»

The same gene network also plays a role in programming the fly neurons responsible for taste, the researchers report in the journal PLOS Genetics.

The drug turns off some of the regulators for the overactive tuberculosis gene network that was fighting off the bedaquiline.

«It appears from these results that gene networks get more complex as social life gets more complex, with network complexity driving social complexity,» Robinson said.

«The drugs activate the endurance gene network, which promotes energy metabolism and revs the muscle up to be able to burn fats,» says Ronald Evans of the Salk Institute in La Jolla, where the work was done.

The approach combined experimental synthetic biology led by Mark Isalan, now Reader in Gene Network Engineering at the Department of Life Sciences of Imperial College London with computational modelling led by James Sharpe, ICREA Research Professor and head of the Multicellular Systems Biology lab at the CRG.

Determining the targets of important miRNAs is crucial to uncover the regulatory gene networks that drive the physiological changes in the fat body after blood meal.

«Using the genome data analysis methods developed by co-author Steve Horvath at UCLA, we have uncovered crucial gene networks and we can now predict possible future genetic disorders at the eight - cell stage.»

«Our systematic screen offers an important first step toward the comprehensive identification of all miRNAs and their potential targets that serve in gene networks important for normal learning and memory,» said Ron Davis, chair of TSRI's Department of Neuroscience who led the study.

This encapsulated gene network is then implanted under the skin where it constantly monitors the blood calcium level.

Jesse Gillis Gene networks; gene function prediction; guilt by association; neuropsychiatric; hub genes; multifunctionality; computational genomics

«We think this conceptual framework could be used to study other diseases caused by mutations in proteins that serve as master regulators of whole gene networks.»

They describe current attempts to isolate the totipotent cells found in stem cell cultures, which involve manipulating gene networks or intercellular signaling pathways.

These damages reduce the body's functioning and brings gene network dysfunction / unstability.

We exploit this genetic bottleneck to define a guidance - gene network governing assembly, with specific glia and pioneer - neuron contributions.

Scientists Identify Age - Associated Defects in Schizophrenia A gene network - based analysis led by Associate Professor Elizabeth Thomas reveals unexpected results.

Could go to Michael Elowitz and James Collins for their pioneering work on synthetic gene networks harnessing DNA, RNA and protein chemisty, with possible inclusion of Craig Venter or George Church for their pioneering work on DNA synthesis.

«The two - gene pattern we designed is a simple example of a cell network, but after proving the concept, we can now move forward to more complicated gene networks.

MicroRNAs establish robustness and adaptability of a critical gene network to regulate progenitor fate decisions during cortical neurogenesis.

We are now working to expand the system and to introduce gene networks that will mimic pattern formation, such as the striped patterns that appear during fly embryogenesis,» explains Tayar.

«The artificial cell system, in which we can control the genetic content and protein dilution times, allows us to study the relation between gene network design and the emerging protein dynamics.

The most recent GENE networking meeting, GENE Roundtable 29, took place in Dublin, Ireland, in early May 2013, kindly hosted by the Development Cooperation Division of the Department of Foreign Affairs and Trade, Ireland.

The emerging picture that denotes «girlness» or «boyness» reveals the involvement of complex gene networks — and the entire process appears to extend far beyond a specific moment six weeks after gestation when the gonads begin to form.

Four speakers in the fields of animals, plants to microbe will intensively quantitatively demonstrate evolutionary and developmental dynamics of gene networks regulating phenotypes (embryogenesis, organogenesis to antibiotic resistance), by combining theoretical analysis with genomics.

«Recreating the stripe patterns found in animals by engineering synthetic gene networks.»

He added that the method used in this study, called «network biology» — where computer systems are used to identify gene networks that work together to underpin disease — may also help find treatments for other conditions.