Sentences with phrase «gene switches»

It's able to do this because of this very complicated network of genes switching on other genes, turning off other ones; there are feedback loops built into it.

In mice, the team has succeeded in making the IL - 2 gene switch on in melanoma cells.

Instead, they simply exposed human skin cells to four natural gene switches, called transcription factors.

The removed gene region thus appears to act as an important gene switch promoting cancer, and without it tumors develop much more rarely.

Holger Willenbring of the University of California, San Francisco, and his colleagues worked out a way to transform myofibroblasts into healthy hepatocytes using a cocktail of liver gene switches called transcription factors.

Exclusive: in a technological breakthrough, the system of gene switches in Neanderthals has been uncovered, allowing us to assess their mental life

Through processes called transcription and epigenetics, those critical genes switch on to guide the process.

Porcar's team engineered gene switches in Escherichia coli to produce proteins that emit different coloured fluorescent light when factors such as heat, acidity and oxygen levels change.

This test determined that only a few genes switched off when signaling was blocked — and one of them was the gene known to code for MHCI.

«Specific gene switches have been identified that could enable light to target unhealthy cells»

Keith Pardee, a colleague of Collins, improved the test by inserting tailor - made gene switches that prevent any colour change happening unless a very specific target molecule is present.

«Our aim now is to study the role of these new gene switches in disease models.»

They then used genome - wide analysis to search for genes switched on by KLF4 at a late stage of reprogramming.

Epigenomics studies the chemical tags that lie just outside our genes and direct whether particular genes switch on or off.

He uncovered a protein called Yap1 — a pivotal gene switch in a biochemical circuit called the Hippo pathway — that tamps down or ratchets up the division of cells in response to physiological needs.

Human babies can re-grow heart tissue after a heart attack, but we lose that ability as we age and regeneration genes switch off.

Moshe Yaniv tries to unravel how genetic and epigenetic gene switches are involved in a wide range of biological processes.

Gene switch important in cancer discovered (Karolinska Institutet and University of Helsinki)

«Our study also highlights that growth of normal cells and cancer cells is driven by different gene switches, suggesting that further work to find ways to control the activity of such disease - specific switches could lead to novel, highly specific approaches for therapeutic intervention», says Professor Jussi Taipale, who led the study.

Tinkering with gene switches can have a profound effect on how they behave, and labs around the world are now scanning the genome in hopes of identifying epigenetic modifications — sometimes called «marks» or «tags» — that could serve as biomarkers, helping to predict and identify a wide range of conditions.

To create them, the skin cells need to be reprogrammed to an embryonic state by exposing them to extra amounts of four critical gene switches.

You've just been tasked with discovering which genes in the human genetic code do what by forcefully genetically engineering babies to have certain traits defined by which genes you switch on.

«Cancer cells disguise themselves by switching off genes, new research reveals: A genome - wide map of the genes switched off in aggressive tumors reveals a «signature».»

The same seems to be true of the gene switches that turn on cancer cells.

Gene switches have been identified that work in specific brain areas, potentially enabling targeted treatment of unhealthy cells.

Epigenetic therapies are thought to work in two ways to fix these errors in cancer cells — by correcting the «position» of the gene switches and by making the cell appear as though it's infected by a virus, triggering the immune system.

The target fragment binds to a gene switch in the DNA, which triggers the production of a colourful substance such as the protein that gives jellyfish a green glow under ultraviolet light, or proteins from bacteria that produce colour changes visible to the naked eye.

Simon Fisher — one of the original Oxford geneticists, now at the Max Planck Institute for Psycholinguistics in the Netherlands — has found that the gene switches on in neurons within certain regions of the brain, including the basal ganglia.

By analyzing more than a trillion sequencing letters, the team found over 100,000 gene switches.

In order to locate all gene switches, the Freiburg research team used modern sequencing methods to examine the entire genome — DNA, epigenetic markers and RNA — during the development, maturation and disease of human cardiac muscle cells.

Gene switches have been identified that work in very specific brain areas, potentially enabling light to target unhealthy cells without disrupting healthy ones.

To do so it has to make special enzymes to eat that sugar and it only makes those enzymes if it is exposed to that sugar — it's a signal in a sense — and what happens is that a protein falls off of those genes and essentially the genes switch on and start making their enzymes.

Though this genetic «dark matter» exists outside of our genes, scientists now appreciate that it helps control when and where our genes switch on and off.

In order to locate all gene switches, the Freiburg research team used modern sequencing methods to examine the entire genome - DNA, epigenetic markers and RNA - during the development, maturation and disease of human cardiac muscle cells.

A type of gene silencing treatment in which specially designed DNA molecules are used to switch off a gene

A type of gene silencing treatment in which specially designed RNA molecules are used to switch off a gene

They found that a gene switch called FOXP3 controls the formation of Tregs in the immune system, keeping autoimmune diseases at bay.

The human genome is packed with at least four million gene switches that reside in bits of DNA that once...

He identified FOXP3 as the gene switch that controls the development and function of Tregs, and he later demonstrated how Tregs prevent spontaneous miscarriages by protecting growing fetuses from attacks by the maternal immune system.

Taking a similar tack, Littman's team later uncovered a gene switch called RORgammat, which shapes the development of a subset of helper T cells called Th - 17 cells, which abound in the intestines.

According to the scientists, these results show that although the gene variants — which make individual humans different from each other — in general have a small impact on disease development, the gene switches in which they reside can play a major role.

The flipping of these gene switches negatively impact brain health and function.