Sentences with word «hippocampal»

Eid T, Hammer J, Runden - Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC (2006) Increased expression of phosphate - activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy.

Researchers put this to the test by observing the activity of hippocampal neurons in one rat (the «self») watching another rat (the «other») go through a simple T - maze.

«This is the first study to look at how physical activity may impact the loss of hippocampal volume in people at genetic risk for Alzheimer's disease,» says Dr. Kirk Erickson, an associate professor of psychology at the University of Pittsburgh.

Researchers from the Department of Psychology and from the Department of Biology of Physical Activity at the University of Jyväskylä studied the effects of sustained running exercise, HIT and resistance training on adult hippocampal neurogenesis in adult male rats.

For the first 5 years, Spalding worked on finding an effective way of separating the roughly 20 million neurons in the dentate gyrus from other types of hippocampal cells and then extracting their DNA.

Long - term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function.

Together, these studies demonstrate that a single bout of exercise increases hippocampal theta as well as enhances delta, theta, alpha, and beta power throughout the cortex [68, 69, 71, 83].

In 1975 Kramis, Bland, and Vanderwolf proposed that in rats there are two distinct types of hippocampal theta rhythm, with different behavioral and pharmacological properties (Kramis et al., 1975).

(It is also somewhat problematic that stress itself did not correlate with hippocampal volumes since this was one of the potential hypotheses proposed by the authors and thus, appears to undercut the conclusions.)

Expression of brain derived neurotrophic factor, activity - regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine.

Showing a clear link between hippocampal activity and recognition memory performance in general has previously proven elusive, having been documented in just a few earlier studies.

Based on evidence from electrophysiological studies showing that both synaptic plasticity and strength of inputs to hippocampal region CA1 vary systematically with ongoing theta oscillations (Hyman et al., 2003; Brankack et al., 1993), it has been suggested that the theta rhythm functions to separate periods of encoding of current sensory stimuli and retrieval of episodic memory cued by current stimuli so as to avoid interference that would occur if encoding and retrieval were simultaneous.

Dr. J. Carson Smith, a kinesiology researcher in the University of Maryland School of Public Health who conducted the study, says that while all of us will lose some brain volume as we age, those with an increased genetic risk for Alzheimer's disease typically show greater hippocampal atrophy over time.

Confocal microscope section of rat hippocampal neurons on a bed of vertical silicon nanowires.

Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males.

There has been notable progress recently in dissecting the function of hippocampal circuits in animal models and also in characterizing the fundamental computations involved in human memory formation.

With the use of different inhibitors, it was found in rat hippocampal slices that the induction of L - LTP [produced either by tetanic stimulation or by application of the cyclic adenosine monophosphate (cAMP) analog Sp - cAMPS (Sp - cyclic adenosine 3», 5» - monophosphorothioate)-RSB- was selectively prevented when transcription was blocked immediately after tetanization or during application of cAMP.

E — G, In contrast, exercise increased hippocampal BDNF levels across all three genotypes (E, ANOVA effect of exercise, p = 0.035), with no change in α - tubulin as a loading control (F).

Because of the strong association between hippocampal cell growth and exercise in models, previous work on exercise and the brain has not focused on the entorhinal cortex, despite its critical role in learning and memory until now.

«That is, patients with smaller hippocampal volumes at baseline are shown to more likely exhibit increases in volume with ECT and to show concomitant improvements in clinical symptoms.

Place cells in hippocampal area CA1 may receive positional information from the intrahippocampal associative network in area CA3 or directly from the entorhinal cortex.

Precis of the neuropsychology of anxiety: An enquiry into the functions of septo - hippocampal system

It is interesting to speculate that differences in Pcdh gene regulation may be functionally relevant for hippocampal development.

In particular, physical exercise was reported to increase hippocampal progranulin levels in wild - type mice (Asakura et al., 2011).

Research on cognitive decline and age - related behavioral deficits primarily focuses on morphological and electrophysiological changes in the hippocampus and many studies report age - related deficits in learning and memory due reduced hippocampal synaptic connections and neuron density.

Thus the rat hippocampal EEG oscillation should not, strictly speaking, have been called a «theta rhythm».

The green staining shows hippocampal CA1 engram cells, which store a long - term fear memory and have the light sensitive optogenetic protein channelrhodopsin - 2.

They found that D - serine was necessary for the maintenance of long - term potentiation in the adult hippocampal dentate gyrus and for full NMDAR activity on granule cells.

Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic?

Ma, T., Hoeffer, C.A., Wong, H., Massaad, C.A., Zhou, P., Iadecola, C., Murphy, M.P., Pautler, R.G., and Klann, E. (2011) Amyloid β - induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide.

The profound deficit in acquiring new episodic memories after hippocampal damage in humans was a turning point in the history of memory research.

Across species, performance in the Morris maze assay relies on hippocampal networks that are critically affected in AD (13, 14).

OBJECTIVE To use functional MRI (fMRI) to investigate whether hippocampal activation during a memory task can predict cognitive decline in individuals with mild cognitive impairment (MCI).

However the term «theta» had already become so strongly associated with hippocampal oscillations that it continued to be used even for rats.

The result is important because, according to previous research, the new hippocampal neurons produced as a result of neurogenesis are needed among other things for learning temporally and / or spatially complex tasks.

«Ultrafast endocytosis at mouse hippocampal synapses.»

The researchers saw that some of these entorhinal neurons fired when the rats moved onto or through a particular spot in the box, just like hippocampal place cells.

Cell lysates of hippocampal tissue from the aged huAPP / PS1 and control mice were analyzed for an effect of J147 on the APP processing pathway by immunoblotting with antibodies against BACE (D) and APP (E).

In contrast, hippocampal engram cells were activated by natural cues on the second day after receiving a foot shock, but not on day 13 — indicating engrams in the hippocampus become active immediately, but gradually fade into a «silent» state.

Abnormal structural features of the hippocampus may also represent still another phenomenon, in that several other mental disorders not characterized by posttraumatic stress and dissociative symptoms are also associated with decreased hippocampal volume.

People with temporal epilepsy caused by hippocampal sclerosis (TLE - HS) have impaired memory and find it particularly challenging to recall details of specific events in everyday life.

The amount of time spent freezing in response to the environment is measured on Day 2 as hippocampal dependent memory, whereas the amount of time spent freezing in response to the tone on Day 3 is related to hippocampus and amygdala function.

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.

Prenatal stress impairs hippocampal development in rats as does stress in adolescence (77).