Sentences with phrase «host disease»

- host disease compared to 42 percent of patients who typically develop this condition with standard medications alone.

A Phase III Randomized Open - Label Multi-Center Study of Ruxolitinib vs. Best Available Therapy in Patients with Corticosteroid - Refractory Chronic Graft vs Host Disease after Allogenic Stem Cell Transplantation (REACH 3)

Besides the ethical concerns of stem cell therapy, there is a technical problem of graft - versus - host disease associated with allogeneic stem cell transplantation.

In spite of mismatching, cord blood cells cause less graft versus host disease (GVHD) than adult cells.

Histone deacetylase inhibition modulates indoleamine 2,3 - dioxygenase - dependent DC functions and regulates experimental graft - versus - host disease in mice.

Nobel Laureate Dr. Beutler, Regental Professor and Director of the Center for the Genetics of Host Disease, discovered an important family of receptors that allow mammals to sense infections when they occur, triggering a powerful inflammatory response.

Approval for our trial demonstrated that regulatory agencies are amenable to this type of therapy, and enabled us to start a trial in 2017 for our lead therapy, CYP - 001, in the indication of graft vs. host disease, which marks the world's first clinical trial of allogenic iPSC - derived MSCs.

Hyperimmune bovine colostrum has been used in clinical trials for treating AIDS - related diarrhea, diarrhea associated with graft versus host disease following bone marrow transplant, and rotavirus diarrhea in children.

Some crop — and even human — diseases might be stopped dead in their tracks if researchers can harness a new discovery about how pathogens first infect their hosts

It not only offers new hope that we can prevent graft - versus - host disease upfront, but that we can also significantly improve outcomes for patients requiring high - risk transplants.»

Graft - versus - host disease occurs when the donated T cells, white blood cells in the immune system that fight infection, launch a vigorous attack on a patient's organs, including the skin, liver, kidneys, lung, and the gastrointestinal tract.

- host disease prophylaxis after related - donor transplant appears to be safe and associated with lower than expected incidence of acute GVHD.

The IMI could also control and organize access to metadata (the associated host disease phenotype data, for a human gut microbiota sample, for instance) without which meaningful interpretation of the data is not possible.

Potentially everyone can benefit from gene modified T cells and there's no danger of graft versus host disease because it's not a transplant from another person.

Low - dose donor CD8 + cells in the CD4 - depleted graft prevent allogeneic marrow graft rejection and severe graft - versus - host disease for chronic myeloid leukemia patients in first chronic phase.

The infusion of ex vivo activated and expanded CD4 (+) CD25 (+) immune regulatory cells inhibits graft - versus - host disease lethality.

Reduction of graft - versus - host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1.

In patients who are cured, the long term side - effects of the chemotherapy and immune suppression treatment as well as any graft versus host disease.

Blocking a MicroRNA Improves Symptoms of Chronic Graft - versus - Host Disease in Mouse Model (Lymphoma News Today 4/17/2018)

«Uncovering a mechanism causing chronic graft - vs - host disease after bone marrow transplant.»

This is ascribed to «resistance,» suggesting that germs are less important in disease than other factors affecting the condition of the host

This has great impact on patient care as over the past few decades many patients have suffered from engraftment problems and graft versus host disease associated with allogeneic transplantation.

If these results are confirmed and one or more of these FLT3 - targeted drugs become approved by the FDA, testing for the FLT3 biomarker may eliminate the need for thousands of patients to undergo stem cell transplantation (each allogeneic transplant costs hundreds of thousands of dollars and place recipients at grave risk of infection and other complications such as Graft vs. Host disease).

Goyal RK, Lin Y, Schultz KR, Ferrell RE, Kim Y, Fairfull L, Livote E, Yanik G, Atlas M. Tumor necrosis factor - alpha gene polymorphisms are associated with severity of acute graft - versus - host disease following matched unrelated donor bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium study.

Enlivex is developing a treatment for Graft - versus - Host disease (GvHD) resulting from bone - marrow transplants.

And as we now know, chronic inflammation can cause a host diseases and debilitating conditions, including rheumatoid arthritis, heart disease, digestive disorders (from IBD and IBS to Ulcerative colitis and Crohn's disease), asthma, ulcers, sinusitis, atherosclerosis, periodontitis, hay fever, active hepatitis, diabetes, Alzheimer's and even cancer.

Furthermore, the study authors found that the action of ATG16L1 protected tissue against the spikes in TNF - alpha levels seen in graft - versus - host disease, a frequently occurring complication of bone marrow transplants in blood cancer patients.

The work was on the role of interleukin - 1 in the pathology of graft - versus - host disease (GVHD), the mechanism by which the new immune system, which a patient receives as a bone marrow transplant, attacks the patient's body following the transplantation.

She showed that tissue macrophages have unique functional attributes that may have critical clinical implications, including a unique ability to resist genotoxic stress, which contributes to graft - versus - host disease and impacts tumor resistance to radiotherapy.

On the other, there is still an indication and proof of greater harm from more frequent deaths resulting from treatment and from rejection reactions (graft - versus - host disease).

Johns Hopkins Kimmel Cancer Center scientists first used cyclophosphamide to prevent severe graft - versus - host disease (GVHD) after bone marrow transplant involving haploidentical or «half - matched» transplants, a treatment first used in 2000 at the Cancer Center to treat leukemias and other blood cancers.

The less well - matched the donor, the higher the risk for developing graft - versus - host disease (GVHD).

Because invasive aspergillosis is so deadly, the guidelines recommend some patients at highest risk be treated with antifungals to prevent infection, including those with neutropenia and graft versus host disease (GVHD).

- host disease) and a low white blood cell count.

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

Historically, clinicians evaluating a patient for transplant have sought to identify donor cells that are perfectly matched to the patient's cell type, which is considered to be the optimal approach to help ensure successful outcomes and to minimize risk of graft - versus - host disease (GVHD), a serious and potentially life - threatening complication that occurs when the donated immune cells attack the patient's cells as foreign tissue.

Hina had developed the devastating immune reaction known as graft - versus - host disease, in which donor cells attack the walls of the gut, skin, lungs, liver, and sometimes — though rarely — even the patient's brain.

The recipients did not suffer from the many common adverse effects of stem transplants, including the grueling graft - versus - host disease, which can cause severe liver damage, rashes, diarrhea and even death.

«Preventing graft - versus - host disease and relapse after transplant requires a difficult balance of eliminating the bad, overactive effector T cells, without suppressing the good, regulatory T cells,» said Kean, who is also an associate professor of pediatrics at the University of Washington School of Medicine and a member of the Fred Hutchinson Cancer Research Center.

«As a transplant physician, it's beyond heartbreaking to witness a patient develop severe acute graft - versus - host disease after having their leukemia cured through bone marrow transplant,» said Kean.

«Given the serious threat of graft - versus - host disease, new approaches to make stem cell transplants safer for patients remain a critical unmet need,» said Dr. Leslie Kean, the trial's principal investigator and associate director of the Ben Towne Center for Childhood Cancer Research at Seattle Children's.

«To have a therapy at our disposal that safely targets just the T cells causing graft - versus - host disease would represent a major step forward in stem cell transplantation.

Graft - versus - host disease (GvHD) is a common and often deadly complication of bone - marrow transplantation that occurs when immune cells from an unrelated donor attack the transplant recipient's tissue.

Results from a phase 2 clinical trial, presented by Seattle Children's Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life - threatening severe acute graft - versus - host disease (GvHD) in patients receiving hematopoietic stem cell transplants.

«Immunotherapy drug nearly eliminates severe acute graft - versus - host disease: Drug used to treat rheumatoid arthritis improves survival after hematopoietic stem cell transplant.»

«The cell therapy infusion resulted in no toxicity and no occurrences of graft - versus - host disease.»

One complication that may occur is graft - versus - host disease (GVHD), basically donor - derived immune cells attacking the recipient's body.

«Protection for the gut barrier: New approach may prevent graft - versus - host disease: Activating signal paths could protect patients from dangerous immune reactions after stem cell transplantations.»