Sentences with phrase «host response»

The parasite could also directly alter neurons involved in memory and learning, or it could trigger a damaging host response, as in many human autoimmune diseases.

The analysis also showed that the preponderance of host responses shifted rapidly from activation of genes involved in cell damage and inflammation toward those linked to promotion of cellular and organ repair.

For the current study, the same researchers teamed up with John Kash and Michael Katze of the University of Washington School of Medicine in Seattle, who study virus infection and host response at the genomic level.

Prof. Ghedin studies microbial and viral population structures, and how these impact host response to infection and emerging infectious diseases.

We are also interested in the study of the roles of caspase - 2 in host responses induced by other vaccines (e.g., tuberculosis vaccine BCG).

The group also observed that the experimental VSV - EBOV vaccine appears to provide initial protection by triggering innate virus - fighting host responses; these responses partially protected animals challenged with EBOV - Makona within a week after vaccination.

«The long - term goal is to develop new therapeutic strategies based on the molecular host response that not only help to improve survival of patients with severe infections but also could limit the use of antibiotics,» said Henrik Thorlacius, M.D., Ph.D., a researcher involved in the work from the Department of Surgery at Skane University Hospital at Lund University in Lund, Sweden.

Exploratory Research for Advanced Technology (ERATO) Infection - Induced Host Responses Project, Japan Science and Technology Agency, Saitama 102 - 0076, Japan.

Microbial pathogens induce specific host responses or «RNA biosignatures» that can be identified using microarray analyses of blood leukocytes (white cells).

«Paradoxically, the study does offer some good news for those working on live vaccines or live vaccine vectors because these are not just vaccine antigens but organisms in their own right that necessarily manipulate host responses (such as those involving IL28B) for their own survival.

Panretinal donor cell migration also affords better access to Müller glia, which bind and mediate host responses to some neurotrophic factors, including GDNF [26].

The lack of morphological evidence of inflammation under normal circumstances, as well as after antibiotic treatment, prompted us to evaluate host response through LDA analysis of host cytokines.

BACKGROUND AND AIMS: Excessive uptake of commensal bacterial antigens through a permeable intestinal barrier may influence host responses to specific antigen in a genetically predisposed host.

The effect of colonization of cdrA (cell division - related gene)- disrupted Helicobacter pylori to host response in human stomach.

«Understanding the host response will be a critical area in vaccine research,» says George Kemble, vice president of research and development for MedImmune Vaccines, recently purchased by AstraZeneca.

Such research «is transformative in our struggle to visualize the dance between pathogen attack and host response in the initial attack,» says Drew Harvell, a disease ecologist at Cornell University.

Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host response.

The approach of targeting a host response required by a pathogen to cause disease rather than targeting the microbial pathogen is gaining wide support in the medical community.»

Although this study represents only a single case, it provides unprecedented detail on the host response to Ebola virus disease and may inform the development of therapeutics designed to boost or accelerate host factors that most effectively counter the virus and promote healing.

A genomic approach based on analysis of the host response to infection has been investigated as an alternative.

Researchers trying to tamp down GVHD have to deal with a major complication: Some graft - versus - host response is good.

«This improved understanding of the host response to HCV infection, and the HCV entry process, will provide new direction for the development of therapeutic treatments to either heighten this natural response, or generate mimics to target the virus specifically.»

«We developed a computer model that shows how the immune system can react to hCMV peptides to trigger a graft - versus - host response,» explained Toor.

We further report evidence for an interaction between oncogenic mutations and host response to melanoma, suggesting that patient stratification will improve immunotherapeutic outcomes.

«Angiogenesis is a host response that can be triggered by granulomas, and the bacteria take advantage of it to grow and to maintain a sufficient supply of oxygen, and ultimately to spread,» said David M. Tobin, Ph.D., an assistant professor of molecular genetics and microbiology at Duke University School of Medicine.

Masters Student, Rotation, Dept. of Plant Pathology August 2005 — December 2005 Cornell University, Ithaca, NY Principal Investigator: Dr. Rose Loria This research program investigates the molecular genetics and evolution of plant pathogenicity in Gram - positive bacteria and host responses to infection by these pathogens.

Studies of the host response to viral infection have historically focused on protein - coding genes, thus our understanding of how the non-protein-coding transcriptome, including both viral - and host - derived noncoding RNAs, impacts host - virus interactions is limited.

Here we combine genome biology and pathology tools to investigate the host responses associated with coral diseases, and with patterns of bleaching and tissue loss.

We can change the host response to the cancer, which is otherwise resistant, and make the vessels more mature, temporarily increasing blood flow to the cancer.

The apparent link between environmental stress and degraded coral health, and the recent information demonstrating the complexity of the cnidarians, highlights the need to now understand the biology of the coral host and host responses in these patterns of change.

Cheresh said that the results show that the host response to the cancer — whether or not it is making blood vessel - maturing cells, for example — is critical in terms of susceptibility to therapy.

PET / SPECT imaging modalities provide a new opportunity to study in real - time the pathophysiology of pathogen infection, resulting from pathogen replication, dissemination, and the host response to infection.

This indicates that MAIT cells are probably involved in the host response at the site of pathogen entry, and may regulate intestinal B - cell activity.

Mouse models have provided key findings on pathogen infectivity and host responses to infection [21 — 25].

The host response has been investigated in terms of the gene - expression response.

The host response is of particular importance since cancer actively evades and suppresses the immune system of the host, or patient.

We seek a better understanding of how the mammalian cell resists viral infections and how the virus antagonizes the host response to infection.

«So I'm looking for that mirror image, to try and expand the vision of precision medicine and look at the host response, too.»