Trastuzumab is a humanized monoclonal antibody that targets the HER2 receptor, which is overexpressed in approximately 20 — 30 %
of human breast carcinomas [11].
Carlson BA, Dubay MM, Sausville EA, et al: Flavopiridol induces G1 arrest with inhibition of cyclin - dependent kinase (CDK) 2 and CDK4
in human breast carcinoma cells.
Carlson B, Lahusen T, Singh S, et al: Down - regulation of cyclin D1 by transcriptional repression in MCF - 7
human breast carcinoma cells induced by flavopiridol.
Each circle represents an individual sample
of human breast carcinoma (n = 392 for TCGA dataset; n = 261 for Bittner dataset).
The human breast carcinoma cell line MDA - MB - 231 was purchased from the American Type Culture Collection (ATCC).