Sentences with phrase «human islet»
The phrase "human islet" refers to a small cluster of cells in the pancreas called islets of Langerhans, which are responsible for producing and releasing the hormone insulin. Full definition
We observed that this pathogenic process was active in human islet cells obtained from donors with type 2 diabetes... [7]
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«This is a unique and valuable resource for researchers wishing to begin to understand how gene expression is dynamically regulated in human islet cells,» said Kim.
San Diego, CA (December 9, 2008)-- Novocell, Inc., a stem cell engineering company, today announced a collaboration with renowned stem cell researcher Dr. Shinya Yamanaka of Kyoto University, Japan, to allow Novocell to explore the creation of human islet cells from induced pluripotent stem (iPS) cells.
Following implantation, the cells should develop into human islet tissue, capable of regulating blood glucose.
Novocell also demonstrated earlier this year, that hES - derived pancreatic progenitorsdevelop into human islet cells capable of producing insulin in response to glucose and ameliorating diabetes in animal models.
«Studying human islet cells has been a major challenge in the field of diabetes research for decades because the pancreas essentially digests itself shortly after a person's death,» said professor of developmental biology Seung Kim, MD, PhD.
There's been a growing realization among diabetes researchers that human islet development differs significantly from islet development in typical laboratory animals like mice.»
«Our study charts a new road map for researchers working to use stem cells to replace human islet cells by highlighting changes that normally occur and should perhaps be taken into consideration when analyzing cells for transplant.»
Doug Melton has put in a life - time of hard work in finding a way of generating human islet cells in vitro.
The blood sugar of the diabetic mice were made normal by the gene - therapy - treated human islets on the right.
The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice.
Transplantation of macroencapsulated human islets in patients with brittle diabetes (collaboration with Kings college, London)
After implantation, these cells are expected to become mature human islet tissue including well - regulated beta cells producing insulin on demand.
Initially, Novocell experimented with implanting micro-encapsulated human islet cells.
Poster: In vitro generation of insulin producing cells with insulin secretion kinetics and mitochondrial respiration similar to adult human islets [Poster T2190] Speaker: Dr. Alireza Rezania, Senior Director, Discovery Date / Time: June 23, 7:00 p.m. to 8:00 p.m., PDT
Image of non-diabetic healthy human islet cells that reside in pancreas.
After implantation, these cells are expected to proliferate and mature to human islet tissue including well - regulated beta cells producing insulin on demand.
Still, obstacles remain such as the shortage of human islets, and the loss of insulin independence over time, even with the use of drugs that hold off immune rejection.
Researchers addressed B - cell lines and human Islet cells with preparations of turmeric and observed positive benefits.
Investigators found that autophagy plays a role in clearing IAPP from pancreatic beta cells using three experimental models: pancreatic beta cells, isolated pancreatic islets from mice that express the human form of IAPP, and human islets.
In these two microscopy images, human islets (the source of insulin cells) were poisoned with a drug to remove the insulin cells, and then treated with either an empty virus (left panel) or the therapeutic virus (right panel), and then grown in a diabetic mouse.
TIMP - 1, previously described as being able to protect against cytokine and STZ ‐ induced β cell death [5, 6], was one of the most enriched factors in co-culture experiments using mouse and human islet cells, and the authors found that TIMP - 1 was induced by pro-inflammatory factors which are commonly associated with T1DM.
«We will follow up using more human islets and trying to understand how many of these functions translate from animal models to humans,» says Bonner - Weir, who notes that human islets are far more diverse than those in lab animals.
An Emory transplant team, working with the UGA group, hopes to use this technology to develop pig islet cells as an alternative to human islets to treat patients with Type 1 diabetes.
Université catholique de Louvain, «Study of the mechanisms of control of glucagon secretion in human islets and the long - term effect of low / high glucose,» led by Dr. Patrick Gilon
We are also the coordinating center of the Human Islet Research Network, a role in which we facilitate significant scientific advances in type 1 diabetes.
Human islet amyloid polypeptide expression in COS - 1 cells.