"Human keratinocytes" refers to the outermost layer of skin cells found in our bodies. These cells produce a protein called keratin, which makes our skin strong and helps protect it from damage.
Full definition
The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction
in human keratinocytes independently of a DNA damage response and cell cycle regulators.
For the expansion and differentiation
of human keratinocyte stem cells for permanent skin restoration in victims of extensive burns.
ATR - Chk1 pathway inhibition promotes apoptosis after UV treatment in
primary human keratinocytes: potential basis for the UV protective effects of caffeine.
«We culture typical skin cell of the epidermis, such
as human keratinocytes, in our dishes to form an artificial epidermis with all of its natural layers,» explained Sibylle Thude, the biologist who led the investigation into the accreditation.
Moreover, various somatic cell types, including mouse liver and stomach [10], pancreatic cells [11], lymphocytes [12], neural progenitor cells (NPCs)[13], [14], [15], human keratinocytes [16], [17] and human CD34 + cells [18], have been reprogrammed.
In a study published in Molecular & Cellular Proteomics, researchers at the University of Freiburg led by Jorn Dengjel performed a global transcriptome and proteome profiling comparing primary DEB keratinocytes to
normal human keratinocytes.
After
exposing human keratinocyte skin cells to p.acnes bacteria, the cells began to churn out high levels of superoxide anions within 15 minutes.
Pioneering work by Barrandon and Green more than 20 years ago (2) showed that when
primary human keratinocytes were put in culture, their abilities to establish a clone were related to the heterogeneity in cell size — only cells ≤ 11 μm in diameter could form a clone whereas cells ≥ 12 μm were irreversibly committed to terminal differentiation.
AV119, a Natural Sugar from Avocado gratissima, Modulates the LPS - Induced Proinflammatory Response
in Human Keratinocytes.
A comparison of epidermal equivalents generated from iPSC, hESC and primary
human keratinocytes (skin cells) from skin biopsies showed no significant difference in their structural or functional properties compared with the outermost layer of normal human skin.
Conclusion The findings indicate that curcumin indeed possessed powerful inhibition against hydrogen peroxide damage in
human keratinocytes and fibroblasts.