Cells engineered to produce insulin under the command of a smartphone helped keep blood sugar levels within normal
limits in diabetic mice, a new study reports.
Introducing extracellular vesicles secreted from the GMSCs of healthy mice reduced wound healing
time in diabetic mice.
Yu and his research team discovered that
in the diabetic mouse cornea, the density of sensory nerve fibers and their endings are drastically reduced, similar to patients with DPN.
B cell treatment also quickly reduced the size and improved the healing of chronic skin
ulcers in the diabetic mice, increasing the number of both nerve endings and blood vessels in regenerated tissue.
In these two microscopy images, human islets (the source of insulin cells) were poisoned with a drug to remove the insulin cells, and then treated with either an empty virus (left panel) or the therapeutic virus (right panel), and then
grown in a diabetic mouse.
This gene therapy approach restored normal blood glucose levels
in diabetic mice for an extended period of time, typically around four months, and the new insulin - producing cells derived almost exclusively from alpha cells.
Firstly, they observed that beta pancreatic cells in non-diseased mice produce cathelicidins and that, interestingly, this production is
impaired in diabetic mice.
«By decreasing ROS levels within a chronic
wound in a diabetic mouse model, my lab was able to normalize conditions and heal the wound,» Martins - Green said.
In fact, the speed and kinetics of touching down to safe blood glucose levels are
identical in diabetic mouse models treated with Ins - PBA - F and in healthy mice whose blood sugar is regulated by their own insulin.
Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut
microbiota in diabetic mice — Junping Zheng — Carbohydrate Polymers
Creation of a rich subcutaneous vascular network with implanted adipose tissue - derived stromal cells and adipose tissue enhances subcutaneous grafting of
islets in diabetic mice.
The artificial beta cells were
tested in diabetic mice and within an hour of the injection the mice displayed normal blood glucose levels, and they remained at normal levels for up to five days following a single dose of the synthetic cells.
Oral chronic gavage with
galanin in diabetic mice increases insulin sensitivity, which is associated with an improvement of several metabolic parameters such as glucose tolerance, fasting blood glucose, and insulin.
Preliminary animal studies suggest that dandelion may help normalize blood sugar levels and lower total cholesterol and triglycerides while raising HDL (good)
cholesterol in diabetic mice.
Cyanidin 3 - glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4
expression in diabetic mice.
The study showed that fisetin, a flavonoid contained in abundance in strawberries, promoted survival of neurons grown in culture and enhanced memory in healthy mice, along with prevention of both kidney and brain
complications in diabetic mice.
Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice
They studied the bone metabolism at the cellular level using advanced imaging and computational techniques, which allowed them to identify 142 metabolites that were significantly altered by more than 1.5
times in the diabetic mice.
Published in the journal Nature Medicine, the team describes successfully using electromagnetic waves to turn on insulin production to lower blood
sugar in diabetic mice.
Alpha cells normally produce the blood sugar - raising hormone glucagon, but
in diabetic mice they started producing insulin instead.
Starting from human skin cells, researchers at the University of Iowa have created human insulin - producing cells that respond to glucose and correct blood - sugar levels
in diabetic mice.
Saghatelian and his colleagues had found that boosting the levels of one key FAHFA lipid normalizes glucose levels
in diabetic mice and also reduces inflammation.
Similarly,
in diabetic mice, nicotinamide mononucleotide markedly reduced blood sugar, weight gain, and liver fat, while also preventing diabetic nerve damage.64
Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice