Sentences with phrase «in endothelial cells»

However, when the researchers knocked out SIRT1 in endothelial cells of 10 - month - old mice, then put them on a four - week treadmill running program, they found that the exercise did not produce the same gains seen in normal 10 - month - old mice on the same training plan.

Dynamics of RhoGTPase activity in endothelial cells induced by addition of nocadozole.

The scientists in Augustin's laboratory consequently pursued preclinical tumor therapy experiments, which were aimed at not just blocking angiogenesis, but to also suppress the production of tumor - promoting growth factors in endothelial cells.

This study examines long - term changes in endothelial cell density in eyes implanted with Artisan (Ophtec BV) iris - fixated phakic intraocular lens.

The scientists began with a line of mice in which the gene for the insulin receptor has been knocked out in endothelial cells only.

Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1 - dependent Genes in Endothelial Cells: COMPARISON OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATIN M

Also, enhanced targeting of nanorods was seen in endothelial cells in the brain, which has historically been a challenging organ to target with drugs.

If we understand the special features of insulin resistance in endothelial cells, we may be able to find more effective treatments against artery damage and cardiovascular disease in people with diabetes.»

In their latest study, Guarente and his colleagues decided to explore the role of sirtuins in endothelial cells, which line the inside of blood vessels.

«The effect of the precursors that boost NAD is to counteract the decline that occurs with normal aging, to reactivate SIRT1, and to restore function in endothelial cells to give rise to more blood vessels.»

They also found stroke - associated «upregulation» of Beclin - 1 in endothelial cells composing the BSCB.

«We were able to look back in the history of these tumor cells and see that they retained genes important in endothelial cell development,» Hatley said.

To make their molecular delivery vehicles, the researchers combined the polymersomes with a protein called LRP1, which is abundant in the endothelial cells that make up the blood — brain barrier wall.

In these studies, they used mice that had been specially bred to express a fluorescent green protein in their endothelial cells.

«Up to now, the Tie2 receptor has only been known in endothelial cells that line the inside of blood vessels,» Milde said.

Malanchi and colleagues show that POSTN is expressed primarily in fibroblasts and to a lesser extent in endothelial cells but is not expressed in immune cells at sites of metastasis (Malanchi et al., 2012).

We show that TNF administration damaged the liver vascular endothelium and induced phosphorylated mixed lineage kinase domain - like (phospho - MLKL) reactivity in endothelial cells isolated from TNF / zVAD - treated WT, but not Ripk1D138N / D138N, mice.

Taken altogether, the evidence «suggests that if you can improve insulin action in endothelial cells, you may be able to slow or prevent atherosclerosis,» Dr. Rask - Madsen notes.

Cadmium overkill: autophagy, apoptosis and necrosis signalling in endothelial cells exposed to cadmium.

The siRNA can also cause side effects in endothelial cells of other organs, which don't need treatment, when administered to the whole body.

«We've discovered that when anti-angiogenesis drugs are used to lower the level of VEGF within a tumor, it's not so much a reduction in the endothelial cells and losing blood vessels as it is an activation of the tumor blood vessels supporting cells,» said Cheresh.

mouse liver, IHC - P, high background in endothelial cells.

«The second step involving Akt activation by R - Ras stabilizes the microtubule cytoskeleton in endothelial cells, creating a steady architecture that promotes lumen formation.»

Expressed in the liver, with highest levels in Kupffer cells and lower levels in endothelial cells as well as hepatocytes, particularly in perivascular areas (at protein level)(PubMed: 15864349, PubMed: 21987372).

In addition, the team noted that soraphen A could be a useful chemical tool for studying fatty acid metabolism in endothelial cells.

Selectively expressed in endothelial cells.

Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.

The researchers also found that SIRT1 activity in endothelial cells is critical for the beneficial effects of exercise in young mice.

These analyses showed that Angiopoietin - 2 is not just affecting angiogenesis, but controls at the same time the production of tumor promoting growth factors in endothelial cells.

They then asked why biglycan expression was increased in the endothelial cells, and found that the promoter region of the gene was de-methylated, meaning the gene was switched on.

To do that, they deleted the gene for SIRT1, which encodes the major mammalian sirtuin, in endothelial cells of mice.

They then tested the most promising of those in endothelial cells to see if they could interfere with a gene called TIE2, which is expressed almost exclusively in endothelial cells.

«In endothelial cells, glutamine is metabolized to ammonia,» Durante said.

Expression and function of the homeostatic molecule Del - 1 in endothelial cells and the periodontal tissue.

The new findings build on a 2010 study conducted by Rask - Madsen, which found that insulin resistance only in endothelial cells is sufficient to increase susceptibility to atherosclerosis.