Sentences with phrase «in human cancer»

However, he adds that he remains totally committed to this general approach of using human gene editing to study human cancer genes in human cancer cells themselves.

They also found that drugs that target this newly identified cancer pathway can prevent tumor growth, both in human cancer cells and mice with a form of brain cancer.

Many owners hesitate to pursue chemotherapy in their pets based on their knowledge of side effects in human cancer patients.

The exact same dominant - negative mutations are among the most commonly observed mutations in human cancers.

Dogs play a crucial role in human cancer research.

As in human cancer research and treatment, canine cancer is big business.

He witnessed the same phenomenon that he had seen in the human cancer genome databases.

Many owners hesitate to pursue chemotherapy in their cats based on their knowledge of side effects in human cancer patients.

They then tested the same system in human cancers that had been grown in mice.

The new study doesn't provide direct evidence of this group migration in human cancer.

It is now established beyond any doubt that alterations in our genes are the fundamental initiating event in human cancer.

Importantly it is also one of the most frequently activated genes in human cancer.

It's been on everyone's «target» list for more than 30 years due to its status as the most commonly mutated oncogene in human cancers.

While it is difficult to say at this point what types of cancer might be amenable to such an approach, this new concept could lead to an improvement in human cancer treatment in the long term, the researchers say.

«This partial reliance of one tumor - suppressor on another was a surprise,» says principal investigator and co-corresponding author Carlo M. Croce, MD, director of Ohio State's Human Cancer Genetics program and the John W. Wolfe Chair in Human Cancer Genetics at the OSUCCC — James.

After scanning the Cancer Genome Atlas, a database of genes expressed in human cancers, the research team discovered that the activity of both HMGA1 and SOX9 genes are tightly correlated in normal colon tissue, and both genes become highly overexpressed in colon cancer.

The study, which appears in Science, offers a novel opportunity to develop drugs that could potentially inhibit this pathway in human cancer cells and help control their growth.

Honored for discovering «the first consistent chromosome translocation in any human cancer,» according to Albany Medical College, the 88 - year - old Rowley is still a professor of medicine at the University of Chicago in Illinois.

I have been especially interested in testing drugs that can inhibit MMPs in cancer models and in understanding why such drugs have not been effective in human cancer patients.

Our primary experimental approach involves creation of engineered mouse strains with informative genetic mutations, characterizing these mice and their cells to elucidate molecular mechanisms underlying cancer phenotypes, and verifying these mechanisms in human cancer patient specimens.

Analytical methods for inferring functional effects of single base pair substitutions in human cancers Human Genetics DOI: 10.1007 / s00439 -009-0677-y

The availability of the human genome sequence allows scientists to scan sequences to identify kinases, and the increased speed with which DNA can be sequenced enables us to rapidly search for mutations in those kinases in human cancers.

His ground - breaking innovation, a limb - sparing technique for the treatment of canine osteosarcoma, has been widely adopted in human cancer centers and has helped countless children facing this dreaded disease.

In tomorrow's issue of The New England Journal of Medicine, researchers from the University of California, San Francisco, and Roche Biomedical Laboratories report convincing evidence that the NF1 gene acts as a tumor suppressor in human cancer.

Using CRISPR, I was able to knockout BRAF in a human cancer cell line in about 1 month, which I'd say is pretty amazing.

By supporting this foundation, you are not only raising money for dogs with cancer, but also for people with cancer, since clinical trials in dogs help decide medicines that are effective in human cancers as well.

Following that, I joined Celera's proteomics initiative, which was trying to unravel the complex proteomic signatures in human cancers.

At the same time, the study results provide further argument for notion that m6A methylation, partly controlled by ZFP217 signaling, is relevant in human cancers.

The role of RNA editing in human cancers is only beginning to emerge from those early studies of individual patient samples in a few cancer types.»

He says it's also important to understand the protein's biological role in cellular signaling and normal animal development as well as to consolidate its role in human cancer development, progression and drug - resistance.

Mutations in the gene encoding Importin - 11 have been identified in human cancers, and Trotman and colleagues found that tumors from lung cancer patients lacking Importin - 11 tended to show low PTEN levels as well.

The study not only shows that NPTX2 is active in kidney cancer, but is the first to reveal that the gene is over-expressed in any human cancer.

A small dose of 1.56 µM, which is approximately equivalent to a daily dose of the drug in a human cancer patients, increased the fruit flies» average life expectancy by 8 %.

«That gives us a few more possible targets for drugs that diminish their threat in human cancer.»

To validate their computer modeling predictions, researchers performed experiments in human cancer cell lines, mouse liver samples and primary human hepatocytes.

«Additionally, this provides evidence needed to begin investigating a vaccine in human cancer clinical trials to determine whether genetically modified tumor cells producing IL - 15 and IL - 15Rα may induce anti-cancer responses.»

Like humans, dogs» tumors are spontaneously occurring, rather than genetically created as they are in mice, so canine tumors may more accurately mimic the situation in human cancer patients.

Their preliminary findings indicate that MUS81 - induced movement of DNA to the cytosol also occurs in human cancer cells, including prostate cancer, breast cancer, colorectal cancer, uterine cancer, leukemia, and melanoma cells.

In this study, the last three amino acids of the Pten protein, which are often missing in human cancers, were found to be critical for forming an intact mitotic spindle, a structure required for accurate chromosome segregation.

Nevertheless, Mr. Wright was confident that a new anticancer drug called Krebiozen would cure him, according to a 1957 report by psychologist Bruno Klopfer of the University of California, Los Angeles, entitled «Psychological Variables in Human Cancer.»

With molecular biologist Gregory Hannon of Cold Spring Harbor Laboratory in New York state, Elledge developed genetic tools that examine how genes function in human cancer cells.

His research currently focuses on determining the mechanisms and consequences of cohesin gene inactivation in human cancer.

In one study, she discovered that inhibiting Aurora - A kinase, an enzyme involved in healthy cell proliferation that is often overexpressed in tumors, could decrease the spread of ovarian cancer in vitro.2 In another project, she found that the transcription factor TWIST1, which regulates aspects of embryonic development, is constitutively degraded in human cancer cells.3

«It's probably the single most common gene fusion in human cancer,» said study co-leader Antonio Iavarone, MD, professor of neurology and of pathology and cell biology (in the Institute for Cancer Genetics) at CUMC.

Therefore, a majority of recurrent focal deletions found in human cancers originate from CFSs instable in the cell types from which the cancers derive.