Sentences with phrase «in tumour cells»

STAT3 is frequently activated in tumour cells, so drugs targeting STAT3 could be used in cancer therapy.

In collaboration with Dr Gabriele Bonatz from the Augusta clinics in Bochum (Brustzentrum), Hatt's team confirmed the existence of TRPV1 in tumour cells in nine different samples from patients suffering from breast cancer.

«With this breakthrough it is possible to generate cell models with the same alterations as observed in tumour cells from patients, which will allow us to study their role in tumour development,» says CNIO researcher Sandra Rodríguez - Perales.

Putting together their analyses of the mitochondrial DNA in each tumour cell line and the metabolic pathways at work, the team were able to deduce how each cell line's genetics directly affected its ability to multiply.

The team is already testing the drugs in the tumour cell lines it created.

The AR - V7 variant is formed when an androgen receptor loses the end part of the receptor, called the C - terminal end; this is deleted due to an error in RNA processing in tumour cells, leaving only the beginning part of the receptor, the N - terminal end.

«Recent data have shown that a variant of the androgen receptor called AR - V7, found in tumour cells circulating in the blood of patients with metastatic CRPC, predicted resistance to treatment with enzalutamide and abiraterone,» she will say.

«We would hope to create little protein factories in the tumour cell that are only switched on when the cells are hypoxic,» says Kingsman.

The researchers found the same mutations in the tumour cells, but not in normal sperm - producing cells located nearby.

Rogers thinks the bisphosphonates in tumour cells somehow change how macrophages behave — those that had been co-opted by the cancer to hide the tumour suddenly switch sides and attack the cancer, gobbling it up.

But at the time, they thought it might take years to pinpoint the precise position of the gene, sequence it, and understand how it causes mutations to accumulate in tumour cells (This Week, 15 May).

«Pembrolizumab is a PD - 1 antibody approved for second line treatment of patients with advanced non-small-cell lung cancer (NSCLC) and PD - L1 expression in their tumour cells,» said lead author Professor Martin Reck, chief oncology physician, Department of Thoracic Oncology, Lung Clinic Grosshansdorf, Germany.

«If these data can be replicated in cells from more advanced organisms, they may begin to raise concerns about targeting Hsp90 in the clinic because of the potential to cause diversity in tumour cells,» Burrell agrees.

One finding was that a cell signal pathway called Wingless and its central signal molecule, beta - catenin, can regulate the production of MGMT in the tumour cell.

The study also shows that viral infection also causes major adaptations in the tumour cell, and that virus - positive tumours from widely different organs can therefore display considerable similarities.

She has worked in prestigious Institutions like the NIH - NCI, Bethesda, Md and the MIT, Cambridge, MA and developed an internationally recognised research profile in tumour cell migration and invasion with over 65 publications and 2 patents to her name.

By understanding the survival factors that keep cancer cells alive we aim to develop new and effective drugs that can activate natural cell death or inhibit impaired survival mechanisms in tumour cells.

We have identified a number of key transcription factors that are deregulated during this process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in tumour cells.

A map of which genes that are switched on or off in tumour cells of uterine cancer, has been created by researchers, identifying a range of potential therapeutic targets

They thus confirmed their hypothesis: the integration of viral DNA was found more often in tumour cells than in healthy cells in these 11 patients.

That «something else» could lie in the tumour cells themselves.

Gerard's lab also sees PD - L1 upregulation by MYC, but intriguingly, how this happens varies depending on cancer type: when MYC is switched on in pancreatic cancer models, PD - L1 is upregulated on the tumour cells themselves, whereas in a non-small cell lung cancer model, it is switched on solely in the macrophages that flood the tumour, despite MYC being activated only in the tumour cells.

After a post-doctoral experience in The Jackson Laboratory in Maine, USA he returned to Italy to pursue a scientific career in tumour cell biology, during which he published his work in prestigious scientific journals with the support of several funding agencies including the European Community, Associazione Italiana Ricerca sul Cancro (AIRC) and the Italian Ministry for Health.

These studies demonstrate that SLC6A14 is critical for the maintenance of amino acid nutrition and optimal mammalian target of rapamycin (mTOR) signalling in ER + breast cancer and that the transporter is a potential target for development of a novel class of anti-cancer drugs targeting amino acid nutrition in tumour cells.

However, no connection has yet been made between the lysosomal amino acid transporters and increased mTOR activity in tumour cells.

If the transporters that are specifically induced in tumour cells compared with normal cells are identified, blocking the function of the induced transporters would offer a logical and effective strategy for cancer therapy with little effect on normal cells.

T cells from the patient's own blood cells are isolated and equipped by genetic means with a new receptor that recognizes an antigen that is expressed in the tumour cells.

In tumour cells from patients with malignant glioma and some forms of ovarian cancer, more PDGF RTK is produced than in healthy brain and ovarian cells.

Radiotherapy and some cancer drugs work by attacking the DNA in tumour cells.

STAT3 is a frequent culprit and is often found to be activated in tumour cells.

We have developed pre-clinical models to identify genes, both in the tumour cells and in the microenvironment that regulate the spread of cancer to specific organs such as the liver, lungs and brain.

Her group has developed pre-clinical models of metastatic disease that are used to identify genes, both in the tumour cells and in the tumour micro-environment that regulate the process of metastasis to specific organs such as bone, liver, lung and brain.

In tumour cells, the signals controlling cell growth and survival are dysfunctional, thus enabling the cells to grow in an uncontrolled manner.