Sentences with phrase «in yeast cells»

But the real puzzle is why these things exist in yeast cells in the first place.

However, very little was known about similar structures in yeast cells.

Susan Lindquist, PhD, professor of molecular genetics and cell biology, and colleagues showed that an improperly folded protein in yeast cells clumps together and then corrupts other, healthy molecules of the same protein to do likewise, in a process much like the «seeding» of a crystal.

And Exo1p may have more tricks up its sleeve: Bertuch and her colleagues, along with Lydell's group, have papers in press showing that Exo1p can accelerate aging in some yeast cells.

Upon joining the lab, Lee chose a high - risk project — «it sounded like more fun,» she says — aimed at determining whether a key gene in the yeast cell cycle, cdc2, was also present in human cells.

August 2, 1996 Protein particles similar to those suspected in «mad cow» disease found in yeast cells Researchers at the University of Chicago's Howard Hughes Medical Institute have shown that a defective cell trait can be propagated by a faulty protein, without any DNA or RNA serving as the genetic blueprint.

Szostak had started a bold project aimed to construct artificial chromosomes that would enable scientists to clone a large cluster of human genes — 10 to 20 — on a single linear molecule of DNA in yeast cells.

Enzymes need energy supplies, too, and some of them require the assistance of additional molecules that may abound in the organism they come from, but not necessarily in a yeast cell.

The autophagy machinery in yeast cells is similar to that in human cells, and Ohsumi's work, which began in the 1990s, gives scientists new targets for possible treatments.

The researchers deployed this technology in yeast cells that are genetically engineered to overproduce a protein associated with Parkinson's disease, known as alpha - synuclein.

When the researchers inserted bacterial prions in yeast cells, the prions began self - propagating and multiplying, a sign of their infectivity.

After the telomeres had deteriorated, the pair examined the chromosomes in yeast cells closely.

Not all vaccines are produced using the same antiquated system; for example, the HPV vaccine known as Gardasil, which was approved by the FDA in 2006, is made in yeast cells.

They found that an enzyme in yeast cells degrades the ends of certain chromosomes, leaving them prone to further abnormalities.

In order to describe the mechanism of a membrane sensor which measures the degree of lipid saturation in the yeast cell, the researchers used genetic and biochemical methods and simulated the motions and underlying forces of membrane lipids over a period of a few milliseconds by means of extensive molecular dynamic simulations.

But hang on to your moisturiser for now: the effects have been demonstrated only in yeast cells.

The protein coating could be manufactured in yeast cells modified to express the wasp saliva gene.

Whether in a yeast cell or in a neuron, alpha synuclein directly interfered with the rate of production of proteins in the cell, and the transport of proteins between cellular compartments.

In 2003 Sinclair's lab published a paper in Nature that described the discovery of a gene that switched on in the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.»

«Our cell biological analysis show that a helicase, called Pfh1, binds to specific guanine - rich DNA sequences in the yeast cell.

Mapping where proteins travel in yeast cells helps decipher their function.

In one experiment, researchers sifted through a protein library produced in yeast cells to select antibodies that bound most tightly to a cancer target.

Rancanti et al. found that aneuploidy facilitated adaptive evolution in yeast cells lacking the conserved motor protein Myo1 involved in cytokinesis [12].

Ohsumi eventually showed that the same processes he observed in yeast cells occur in human cells.

Understanding the role of frataxin and how repeats block its synthesis started with studies in yeast cells and then fruit flies, Ansari says.

Postdoctoral fellow Aaron Gitler now is searching for the original defect that the Parkinson's protein triggers in yeast cells in hopes of identifying the underlying disease pathway and key drug targets.

Jun 20, 2017 AM EDT MIT researchers have identified the gene that affects the aging process in yeast cells.

In a screen of nearly 200,000 compounds, Tardiff and collaborators identified one chemical entity that not only reversed alpha - synuclein toxicity in yeast cells, but also partially rescued neurons in the model nematode C. elegans and in rat neurons.

In a paper published today online in Nature Genetics, researchers in the laboratories of Stanford Associate Professor Aaron D. Gitler, PhD, and Gladstone Senior Investigators Robert V. Farese, Jr., MD and Steve Finkbeiner, MD, PhD, describe how shutting off a gene called Dbr1 in yeast cells and in neurons obtained from rats can protect both cell types from the toxic effects of TDP - 43 — a protein that plays a key role in ALS.

Senior author of the study Xuetong «Snow» Shen, Ph.D., associate professor in The University of Texas MD Anderson Cancer Center Department of Molecular Carcinogenesis, developed a unique model system to nail down actin's function in the nucleus: the actin - containing INO80 chromatin remodeling complex in yeast cells.

Most of this research was established in yeast cells, but connections between histone ubquitination and histone methylation, for example, also occur in human cells.

These imaging techniques were then used directly or in combination with optical manipulation techniques (laser dissection and optical tweezers) for the study of the mitotic spindle dynamics and the nucleus positioning in yeast cells.

Caprylic acid, which comes from coconut oil, basically «pokes holes» in the yeast cell wall, causing it to die.

Protection of DNA from damage in yeast cells and destruction of human liver cancer cells have also been demonstrated.

And researchers at the «Seattle project», an effort funded by the National Cancer Institute to find new anticancer drugs, are mutating genes in yeast cells — such as the ATM gene or the mismatch repair genes — that often lead to cancer in humans.

Dietary sources of MOS include natural fibers found in yeast cells.

«Mapping the genes that increase lifespan: Comprehensive study finds 238 genes that affect aging in yeast cells.»

Using 3 - D time - lapse movies to track the fate of misfolded proteins in yeast cells, the researchers determined that about 90 percent of aggregates form on the surface of the endoplasmic reticulum (ER), a location of protein synthesis in the cell.

A team of researchers at the Center for Molecular Biology of Heidelberg University (ZMBH) has recently discovered that in yeast cells, the amount of nutrients that cells are exposed to can affect DNA surveillance and repair mechanisms and therefore the quality of their DNA.

To look at the effects of heat shock on native populations of proteins, Drummond and his colleagues utilized a novel set of techniques that allowed them to simultaneously track almost 1,000 different mature proteins in yeast cells.

In yeast cells, the cell division cycle takes only 1.5 hours — meaning yeast have a very rapid succession of generations.

Some additional experiments in cells confirmed their hunch about the physical interaction between the TDP - 43 and SCA2 proteins, but the scientists wondered whether their discovery is applicable to humans, considering they discovered it in yeast cells.

They noted also that the number of chromosome sets (ploidy) in the yeast cells had an impact on fitness across all of those species tested.

A group of researchers working on ALS (Lou Gehrig's disease) in yeast cells have found an unexpected genetic link between ALS and SCA - 2, a disease in the same genetic family as HD.

In the yeast cells, they showed that the more effectively they prevented full aggregation — by adding more sites mimicking phosphorylation — the more robustly colonies of the cells would grow.