Sentences with phrase «intestinal organoids»
Intestinal organoids are small structures that resemble a miniature version of our intestines. They are made in laboratories using stem cells and are helpful in studying how our intestines work or testing drugs for potential side effects. Full definition
To read and download the publication, see Enhanced Utilization of Induced Pluripotent Stem Cell — Derived Human Intestinal Organoids Using Microengineered Chips
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In the Intestine Chip, the epithelium forms villi - like projections lined by polarized epithelial cells that undergo multi-lineage differentiation similar to that of intestinal organoids, however, these cells expose their apical surfaces to an open lumen and interface with endothelium.
«This work provides a proof of principle for using stem cell - derived human intestinal organoids in a therapeutic setting.»
Stomach organoids can also be used in combination with intestinal organoids to study how the body controls digestion and proper nutrient uptake, as well as a variety of other medical conditions affecting the gastrointestinal tract.
The 3 - dimensional structure of human intestinal organoids makes them challenging to use.
Target Identification and validation using intestinal organoid models and stable cancer cell lines.
For example, a team at the University of Michigan has developed human intestinal organoids, which they use to study disease in both adults and premature infants.
«The special thing about our scientific work on the intestinal organoid is that we can observe its inner workings,» explains Dr. Tamara Zietek of the Department of Nutrition Physiology.
Human intestinal organoids (HIOs) generated in the hydrogel matrix differentiate into mature intestinal tissue and present specialized human intestinal cell types, such as enteroendocrine cells (CHGA; red), after transplantation into an animal.
«We have shown that the hydrogel matrix helps the human intestinal organoids (HIOs) engraft into the intestinal tissue, that they differentiate and accelerate the healing of the wound,» said Andrés J. García, Regents» Professor in Georgia Tech's Woodruff School of Mechanical Engineering.
The intestinal organoids that grew from these elements developed several of the singular characteristics of that tissue type, including small knobby protrusions (crypts) that in full - size intestines serve as receptacles for stem cells.