Sentences with word «kainate»

In addition to clustering AMPA receptors, via a dimerisation domain, PICK1 has been shown to have multiple effects in neurons including roles in the insertion of AMPA receptors (Daw et al 2000), the internalisation of kainate receptors (Hirbec et al 2003) and the regulation of AMPA receptor subunit composition (Terashima et al 2004).

The amount of kainate controls how many astrocytes spontaneously light up and thus produces the background noise.

Kainate added to the cultured astrocytes lit them up; the glow quickly spread to neighboring cells and the wave spiraled like a pinwheel.

The video relies on a cascade of chemical reactions: When a neurotransmitter called kainate binds to the surface of an astrocyte, a molecular floodgate opens and sodium ions rush in.

Publication of Proof that Cot Death Babies Show Physiological Effects of Gaseous Poisoning: «Decreased Kainate Receptor Binding in the Arcuate Nucleus of the Sudden Infant Death Syndrome», Journal of Neuropathology and Experimental Neurology 1997; 56:1253 - 61: proof that cot death babies have neurochemical deficits consistent with poisoning by nerve gases.

This study, by Professor Jeremy Henley and co-workers reports a new type of LTP that is controlled by kainate receptors.

The whole - cell current response to glutamate and kainate [a non-NMDA (N - methyl - D - aspartate) receptor agonist] was enhanced by forskolin, an activator of adenylate cyclase.

Lithium (1 mM) given 20 min before kainate (100 μM 15 min) fully protected G93A SMI32 - positive neurons (SI Fig. 25 a and b).

We isolated NMDA - R EPSC responses for cortical layer 4 → layer 2/3 (L4 → L2 / 3) projections by recording neurons in L2 / 3 while electrically stimulating presynaptic neurons in L4 during constitutive pharmacological block of other ionotropic glutamate receptors (AMPA and kainate receptors) and GABA receptors.

When Cornell - Bell's team added kainate to astrocytes grown from human tissue removed during surgery for epilepsy, the cells glowed in chaotic patterns.

The steady - state current - voltage (I - V) relations of glutamate - and kainate - induced currents through homomeric channels fell into two classes: channels composed of either the GluR - A, - C, and - D subunits showed doubly rectifying I - V curves, and channels composed of the GluR - B subunits displayed simple outward rectification.

Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying alpha - amino -3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)- selective binding pharmacology (AMPA = quisqualate greater than glutamate greater than kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7 - dinitroquinoxaline -2,3-dione (CNQX).

This study, by virtue of showing that only individuals with a certain form of the kainate (glutamate) receptor reduced drinking with topiramate treatment, indicates that this receptor plays a key role in topiramate's effects on drinking.

Although the kainate compounds do not have this problem, they have low affinity action only on one of the transporter subtypes.

All inhibitors of glutamate transporters, with the exception of the kainate - derivatives, have been substrates which are themselves transported.

It has been shown to interact with a number of glutamate receptors - GluA2 and GluA3 AMPA receptor subunits (Dev et al 1999, Xia et al 1999), the GluK1 and GluK2 subuits of the kainate receptor (Hirbec et al 2003) and the mGlu7 receptor (Dev et al 2000) via their extreme C - terminal PDZ binding motifs.

Theanine also increases brain dopamine levels and has a low affinity for AMPA, kainate, and NMDA receptors.»