Sentences with phrase «key mutations»
By assessing the incidence of a particular mutation or the frequency at which certain genes / pathways are altered across multiple patients (of the same tumor type), it should be possible to identify key mutations.
massgenomics.org
«When most people think about cancer genetics, they think about single key mutations that foster tumor formation — very specific things like the BRCA genes,» said Joe R. Delaney, PhD, a fellow in the Clinical Translation program at UC San Diego Moores Cancer Center and lead author of the paper published February 15 in Nature Communications.
By looking at genetic similarities and estimating how long it would take for key mutations to pop up, the researchers assembled a family tree with rough dates.
A sample was more likely to pick up key mutations if taken using the Cytosponge, developed by Professor Rebecca Fitzgerald at the Medical Research Council Cancer Research Unit at the University of Cambridge.
Researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust were able to track key mutations that cancer accumulates as it develops and spreads, without the need for invasive biopsy procedures.
A research team led by a University of Chicago scientist has discovered two key mutations that sparked a hormonal revolution 500 million years ago.
The findings could be used to identify the key mutations that occur early in the development of tumours, allowing doctors to use targeted treatments more effectively.
If researchers can trace the bacterium's evolutionary history, they might be able to identify the key mutations that trigger virulence or adaptation to different habitats, for example.
Even if researchers can pinpoint and transfer those key mutations (a daunting task), DNA is only half the battle.
This revealed that many of the key mutations that allow the cancer to spread had developed more than 20 years before, when the people still smoked.
The recently described eqFP670 and TagRFP657 [15], [18] share these key mutations that were both selected for in Amrose; S158N (eqFP670) and H197Y (TagRFP657).