Sentences with phrase «large number of genes»
The system can yield dose - response curves for candidate drugs, screen the phenotypes of large numbers of gene mutations, or execute complex custom protocols for completely new experiments.
sciencemag.org
The DNA evidence also shows that modern - day Siberian Huskies and Greenland sled dogs share an unusually large number of genes with the ancient Taimyr wolf.
Reinforced by Whiteheadian principles, I was not afraid to substitute for this the concept that development depended on the activities of very large numbers of genes.
Pinker says that the findings are a first step in demonstrating that intelligence relies on large numbers of genes, each with a tiny effect, rather than on single genes that have moderate or large effects, but which are so rare that none has yet been identified.
A peek at tardigrades» genetic diaries may dispel a rumor about an amazing feat the tiny creatures were supposed to perform: borrowing large numbers of genes from other organisms.
She also says that other recent work confirms that it's possible to compute the impact of large numbers of genes using simple arithmetic.
«We don't need large numbers of genes to be an intelligent species,» Rosenthal explains.
Such experiments require not only large numbers of genes but also that those genes are sequenced.
«We have been looking for a way to sift through large numbers of genes at the same time to see whether they affect processes we're interested in,» says Richard Huganir, Ph.D., director of the Johns Hopkins University Solomon H. Snyder Department of Neuroscience and a Howard Hughes Medical Institute investigator, who led the study.
From a relatively small screen, we found a surprisingly large number of genes that seem to operate in an antagonistic fashion.»
A large number of genes previously not linked to developmentally - regulated neuronal death or neurodegenerative pathologies were identified.
A large number of genes involved in nervous system development and function were also deregulated.
Correspondingly, a large number of genes with no direct role in tumor progression also are deleted as a result of their proximity to tumor suppressor genes.
The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.
Chromosomal deletions are difficult to study with existing tools because they contain a large number of genes, making it hard to pinpoint the critical ones causing cancer.
They could identify a large number of genes that were altered in smokers but found no such effect of non-smoke tobacco.
If she finds a large number of genes governing processes that tuck away carbon dioxide, for example, the wetland likely has high carbon storage potential.
The background of migraine is highly complex involving a large number of genes and their interaction with environmental effects, and acting via multiple pathways in the central nervous system.
«The large number of genes makes it less likely that one solution to beat obesity will work for everyone and opens the door to possible ways we could use genetic clues to help defeat obesity,» she says.
«This is the first indication that DISC1 regulates the activity of a large number of genes, many of which are related to synapses,» Ming says.
A comprehensive genomic analysis of Wilms tumor — the most common kidney cancer in children — found genetic mutations involving a large number of genes that fall into two major categories.
This fits perfectly with the gene - switching hypothesis, as such a large number of genes would provide the multitude of disguises that P. falciparum needs.
The scientific community uses knockout mice to analyze basal phenotypes (the appearance of genetic characteristics) to analyze the function of such a large number of genes.
«MEGENA will help scientists flesh out novel pathways and key targets in complex diseases, while SuperExactTest will provide a clearer understanding of the genome by comparing a large number of gene signatures.»
«We didn't know before these results came out that there are a large number of genes with expression levels systematically different between mouse and human,» said Ross Hardison, Ph.D., director, Huck Institute for Comparative Genomics and Bioinformatics at Pennsylvania State University, University Park, and a co-senior author on the main Nature study and other publications.
Because many of the genes influencing facial morphology are likely to have small effects, successfully mapping a large number of these genes will require much greater sample sizes and a more comprehensive approach to quantifying facial features of interest.»
«However, we hadn't realised there may be a large number of genes fueling the interactions, or that these types of genes hamper a species» ability to adapt to new conditions.»
«We observed that a large number of genes were involved in pathways related to wound healing, immunity, and metabolism, and this is consistent with the idea that the earliest stages of domestication may involve adapting to highly crowded conditions,» said Mark Christie, lead author of the study.
In particular, the protein enhances the expression of a well - characterized oncogene called MYC, which in turn regulates a large number of genes involved in cell proliferation.
Most researchers believed that the Y chromosome of cattle would be similar to the Y chromosome of other mammals, which does not have a large number of genes and is considered mostly transcriptionally inactive, Liu said.
That ancestor suffered a process known as «gene decay,» where over a long period of time and multiple generations, a large number of genes mutated, became non-functional, and eventually disappeared.
In the case of IGF2BP3 and B - cell leukemia, the overall effect of the RNA binding protein is to promote the proliferation of B cells by shifting the expression of a large number of genes, Sanford said.
To determine how the cell of origin affected the characteristics of glioblastoma cells, the researchers analysed how the activity of a large number of genes differed between tumors with different origins.
The researchers also found epigenetic changes in a large number of genes that contribute to reduced insulin production.
In research published today in Cell Reports, the team identify a large number of genes that could serve as potential targets for anti-AML treatments and describe how inhibition of one of these genes, KAT2A, destroys AML cells without harming non-leukaemic blood cells.
Ontological analyses showed significant upregulation of a large number of genes in the glutamate receptor family, including 3 of the 5 NMDA subunits.
Two - winged insects such as flies evolved from a four - winged ancestor through the evolution of the regulation of a large number of genes in the insect hindwing.
«It might be difficult to imagine why the large number of gene variants that together give rise to traits like [autism spectrum disorder] are retained in human populations,» co-author and genetics and neuroscience professor Joel Gelernter said in a statement from Yale University.
Large numbers of genes are found in almost every cell.
The scientists discovered that BRCA1 exerts regulatory control over a large number of genes by keeping these DNA bundled together tightly into a structure, known as heterochromatin, inside the nucleus so that it is inaccessible and transcriptionally completely silent.
«The larger number of genes in M. pulmonis... can be mainly attributed to an increased number of membrane proteins,» the researchers write in Nucleic Acids Research.
The revolution in human genetics has revealed a large number of genes and pathways associated with these diseases, and emerging methodologies are starting to systematically analyze the cellular and molecular circuitry underlying disease.
Ikaros's function is to bind DNA and regulate the activity of a large number of genes in cells.
In - silico analysis can yield important insights into this aspect, facilitating comparison of two or more classes of genes comprising of a large number of genes within each group.
Skeletal muscle shares the largest number of genes with heart, which is expected since both heart and skeletal muscles are striated muscles with many similarities.
The fact that a large number of genes are responsive to the effects of TSA and L - methionine implies that the epigenetic regulation of gene expression as a function of maternal care may be extensive.