Sentences with word «metastasis»
Metastasis means when cancer cells spread and grow in different parts of the body away from where the cancer first started. Full definition
Researchers, therefore, have invested significant attention on the processes of cancer metastasis in hope of discovering ways to prevent or even reverse this most lethal step in cancer's progression.
cancerresearch.org
Risk factors for bone metastasis in patients with primary lung cancer: study protocol for a systematic review
Dogs with benign tumors usually do not require further treatment, but cases with malignant tumors should be staged (evaluated for metastasis by tests such as chest X-rays and abdominal ultrasound).
«Complete remission of brain metastasis of difficult - to - treat tumor: Tumor - targeting immune cells appeared to spontaneously reactivate after biopsy of recurrent, subcutaneous lesion.»
High serum concentrations of MMP1 correlate with bone metastasis in breast cancer patients (32).
The international research team — led by the University of Adelaide and including members from the University of Michigan, Vancouver Prostate Centre, the Mayo Clinic and Johns Hopkins University — showed that a specific microRNA (a type of molecule involved in regulating the level and activity of genes) called miR - 194 promotes cancer metastasis by inhibiting a key protein called SOCS2.
Hi Pearl, my cat was diagnosed with spleen cancer with metastasis in the lungs based only on ultrasound.
We report that ABL kinases promoted metastasis of breast cancer cells to bone by regulating the crosstalk between tumor cells and the bone microenvironment.
Shah and his team are currently developing similar animal models of brain metastasis from lung cancers and from melanoma.
Furthermore, these mice would provide an excellent model to test novel therapies aimed at preventing metastasis.
In the orthotopic breast cancer model around 12 % of tail injected iPSC - EPCs homed to the mammary pad region, while in the breast cancer lung metastasis model iPSC - EPCs were distributed predominantly to the lung region.
ZEB1 checks the formation of the binding proteins E-cadherin and Epcam, enabling cells to leave their cell networks — exactly like tumor cells during metastasis in humans.
If left untreated, this growth can spread beyond the lung in a process called metastasis into nearby tissue or other parts of the body.
Now, University of Missouri researchers have found that luteolin, a natural compound found in herbs such as thyme and parsley, and vegetables such as celery and broccoli, could reduce the risk of developing metastasis originating from triple - negative breast cancer in women.
Dr Priscilla Brastianos, MD, a neuro - oncologist and Director of the Brain Metastasis Program at Massachusetts General Hospital, Boston, USA, will say: «Brain metastases are a devastating complication of cancer.
But the absence of these two genes in the tumors was not enough to completely drive metastasis, there was still an unknown mechanism at play.
«Lymph node metastasis of tumors represents a critical step in disease progression through its effects on the immune system» presented by Nathan Reticker - Flynn
Together, our findings uncover a new mechanism for liver metastasis formation involving an active contribution of hepatic vascular fibronectin and talin1 in cancer cells.
Because these techniques allow researchers to monitor molecular movements over time, they are becoming very important for understanding things such as metastasis in cancer, and the way viruses enter cells and where they go.»
Kruger summarizes the research results as follows: «The early metastasis of tumor cells usually constitutes the critical step in cancer development.
For example, CXCR4 is one of the major co-receptors for HIV entry into target cells, while in cancer it plays an important role in tumor cell metastasis.
Human primary osteoblasts matrices as a model system for bone metastasis research.
They not only prevent weight loss, but they can also decrease inflammation and may inhibit metastasis as well.
The decrease in metastasis caused by melanoma cells was especially dramatic and confirmed that NK cells lacking STAT3 are extremely efficient killers of tumour cells.
However, VEGFA affects blood vessels in several ways and sustained anti-VEGFA therapy deteriorates vessel function and can cause increased metastasis.
Using metastasis models that bypass invasion and intravasation, we uncovered roles for the ABL kinases in the regulation of breast cancer cell survival and colonization in the bone microenvironment.
Local recurrence and distant metastasis occur in a non-constant fashion in the years after treatment, and a time - and risk - adapted strategy for aftercare is warranted.
Rejection of lung melanoma metastasis in mice lacking the gene for Cbl - b (down left) or carrying a mutation in this gene (down right), as compared to Cbl - b sufficient mice (upper panels).
Additionally, the study showed that genetic knockdown of RASAL2 gene can lead to reduced metastasis in breast cancer mouse model.
Bennett EE, Angelov A, Vogelbaum MA, Barnett GH, Chao ST, Murphy ES, Yu JS, Suh JH, Jia XJ, Glen HJ, Ahluwalia MS, Mohammadi, The Prognostic Role of Tumor Volume in the Outcome of Patients with Single Brain Metastasis After Stereotactic Radiosurgery.
«Blood vessel lining cells control metastasis, research shows.»
Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary tumor, blocked metastasis of cancer cells from the primary tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained tumor - free.
Patients with elements of Gleason pattern 4 on diagnostic biopsy were at increased risk for eventual metastasis when treated with an initial conservative approach.
To further validate that the decreased metastasis induced by double knockdown of ABL1 and ABL2 was not due to off target effects of the lentivirus - encoded shRNAs, we used a second set of ABL shRNAs (shAA # 2) and carried out rescue experiments by expressing mouse Abl1 and Abl2 constructs (mAbl1 / Abl2) that are resistant to shRNAs against human ABL1 and ABL2.
An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis
Our results led us to speculate that there might be a metastatic subpopulation within stem - like cancer cells since other studies have shown that CSC phenotype alone may exhibit invasive property in vitro but is inadequate to determine or predict in vivo metastasis.
By viewing this fusion as another disease imposed onto tumor cells, scientists could devise new therapies against metastasis, the researchers say in the May Nature Reviews Cancer.
The present study demonstrated that cancer - secreted microRNAs induced osteoblastic bone metastasis through promoting the osteogenic differentiation of bone - forming cells.
A cancer expert argues that our current system for testing drugs fails to fully examine those that might stop metastasis.
Talin1 depletion impaired cancer cell adhesion to the endothelium and transendothelial migration, resulting in reduced liver metastasis formation in vivo.
The x-rays about 4 months into treatment showed metastasis to lungs and spleen.
His research activities currently focus on identifying metastasis suppressor genes in colorectal cancer.
In addition to potentially improving screening tests, the team believes their approach may someday help doctors control CTC - induced metastasis, which the researchers say can be far more lethal than the original tumor.