Sentences with word «methyltransferase»
A methyltransferase is an enzyme that adds a chemical group called a methyl group to a molecule. It helps to modify and control the activity of various molecules in our body, playing an important role in many biological processes. Full definition
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.
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Anita Bledau (Anastassiadis, TUD)-- «SET Histone methyltransferases in mouse embryonic stem cells and mammalian development» (2011)
(2015) Protein arginine methyltransferase CARM1 attenuates the paraspeckle - mediated nuclear retention of mRNAs containing inverted repeat Alus.
Liu, F.; Chen, X.; Allali - Hassani, A.; Quinn, A. M.; Wasney, G. A.; Dong, A.; Barsyte, D.; Kozieradzki, I.; Senisterra, G.; Chau, I.; Siarheyeva, A.; Kireev, D. B.; Jadhav, A.; Herold, J. M.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J. Discovery of a 2,4 - diamino -7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
Barsyte - Lovejoy D, Li F, Oudhoff MJ, et al., PFI - 2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
However, little is known about the specific growth - signaling pathways affected by DNA methyltransferase enzymes like DNMT3B.
Simultaneous quantitative determination of 5 - aza - 2 ′ - deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure - response measures of nucleoside analog DNA methyltransferase inhibitors.
Tao Y, Neppl RL, Huang ZP, et al., The histone methyltransferase Set7 / 9 promotes myoblast differentiation and myofibril assembly.
Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP; Feng Liu, Dalia Barsyte - Lovejoy, Fengling Li, Yan Xiong, Victoria Korboukh, Xi - Ping Huang, Abdellah Allali - Hassani, William P. Janzen, Bryan L. Roth, Stephen V. Frye, Cheryl H. Arrowsmith, Peter J. Brown, Masoud Vedadi, and Jian Jin; J. Med.
For methylation to take place, our bodies need the help of enzymes called methyltransferases.
Green tea extract and catechol - O - methyltransferase genotype modify the postprandial serum insulin response in a randomised trial of overweight and obese postmenopausal women.
SQLE increased the NADP + / NADPH (reduced form of NADP +) ratio, which triggered a cascade of events involving oxidative stress — induced DNA methyltransferase 3A (DNMT3A) expression, DNMT3A - mediated epigenetic silencing of PTEN, and activation of AKT - mTOR (mammalian target of rapamycin).
In mice, we are studying two candidate histone methyltransferases by knock - out and conditional strategies using Cre / lox, as well applying proteomic approaches to characterize the complexes.
While paralogous expansions of pir genes and genes encoding MSP genes have been described in other Plasmodium species, P. cynomolgi exhibits an unexpected expansion of 36 methyltransferase pseudogenes.
Chang, Y.; Zhang, X.; Horton, J. R.; Upadhyay, A. K.; Spannhoff, A.; Liu, J.; Snyder, J. P.; Bedford, M. T.; Cheng, X. Structural basis for G9a - like protein lysine methyltransferase inhibition by BIX - 01294.
Judson RN, Quarta M, Oudhoff MJ, et al., Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.
The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation.
«Our study has identified and validated for the first time an arginine methyltransferase as a novel genetic vulnerability in PDAC,» said Giulio Draetta, M.D., Ph.D., professor of Genomic Medicine and director of Institute for Applied Cancer Science (IACS) at The University of Texas MD Anderson Cancer Center.
A mouse speciation gene encodes a meiotic histone H3 methyltransferase.
Nr is converted into Epi by the enzyme phenylethanolamine N - methyltransferase with SaMe as the cofactor.
Researchers discover that the inhibition of a lysine methyltransferase allows for the long - culture and amplification of human muscle stem cells
CARM 1 promotes nuclear export of special class of RNAs (3/15/15) Assistant Professor Donghang Cheng, Ph.D. in Dr. Mark Bedford's group was the co-corresponding author on a study demonstrating that in the absence of the arginine methyltransferase CARM1, a certain class of protein encoding RNAs remain in the nucleus.
However, over 50 % of GBM tumors generate a DNA repair protein called MGMT (methylguanine methyltransferase) that effectively neutralizes temozolomide chemotherapy.
In the current study, ZFP217 was found to regulate m6A deposition on to mRNAs created by stem cell pluripotency genes by attaching to another enzyme, m6A methyltransferase - like 3 (METTL3), and rendering it inactive.
Dam is an acronym of an enzyme called DNA adenine methyltransferase.
Among key subgroup analysis focused on variations of a gene — O -6-methylguanine-DNA methyltransferase, or MGMT — that can affect a patient's response to treatment.
Furthermore, the study showed that histone methyltransferases Mll1, Mll2 / 4 and Mll3 play a key role in de novo H3K4 methylation.
The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence.
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
A Journal of Biological Chemistry «Paper of the Week» describes the structure of phosphoethanolamine methyltransferase, which is critical for the parasite Plasmodium falciparum's survival.
In fact, mutations in a human protein highly related to the yeast histone methyltransferase Set1, called MLL, are involved in leukemia.
The NS5 protein is constituted by two distinct domains, an N - terminal methyltransferase and a C - terminal RNA - dependent RNA polymerase that are required for capping and synthesis of the viral RNA genome, respectively [5 — 7].
A recent study from the laboratories of Thomas A. Rando (Stanford University, California, USA) and Fabio M. Rossi (University of British Columbia, Canada) now provides evidence that modulation of Setd7, a lysine methyltransferase previously indicated to play a role in myogenesis [2], can enhance the therapeutic value of in vitro cultured MuSCs [3] and may represent the way forward for MuSC - based therapies.
Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT, Chen T. (2017) The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.
Recent work by Fleming researchers demonstrates that the histone methyltransferase Smyd3 is required for the development of experimentally induced liver and colon cancer in mice.
Tachibana, M.; Sugimoto, K.; Nozaki, M.; Ueda, J.; Ohta, T.; Ohki, M.; Fukuda, M.; Takeda, N.; Niida, H.; Kato, H.; Shinkai, Y. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
The researchers were first interested in how neural cells would differentiate in the absence of a certain methyltransferase called DNMT3A.
Greiner, D.; Bonaldi, T.; Eskeland, R.; Roemer, E.; Imhof, A. Identification of a specific inhibitor of the histone methyltransferase SU (VAR) 3 - 9.