Sentences with phrase «mouse fibroblasts»
"Mouse fibroblasts" refers to a type of cells that are found in mice and are responsible for producing and maintaining the connective tissue in their bodies. Full definition
Indeed, a recent report has demonstrated that the small molecule, kenpaullone could replace KLF4 in reprogramming mouse fibroblasts into iPS cells [32].
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Imagine researchers» excitement, then, when Kyoto University's Shinya Yamanaka reported last year that his group had created embryolike cells directly, without transferring chromosomes, simply by injecting mouse fibroblast cells with four genes that are active in embryonic cells but not in adult ones.
They found that the combination of the transcription factors Brn3a plus Ngn1, or Brn3a plus Ngn2, reprogrammed a significant percentage of the embryonic mouse fibroblasts into what looked — and acted — like mature DRG - type sensory neurons.
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy.
It is of interest that during reprogramming of mouse fibroblasts to induce pluripotency, the cell surface marker SSEA - 1 is upregulated very early on in the process [32].
The tyrosine kinase Abl is required for Src - transforming activity in mouse fibroblasts and human breast cancer cells
Deepak Srivastava and his team at the Gladstone Institute of Cardiovascular Disease in San Francisco created mouse cardiomyocytes by exposing mouse fibroblasts to three transcription factor proteins that activate genes needed for the formation of embryonic heart tissue.
Amounts of telomerase RNA increased in immortal cells derived from primary mouse fibroblasts.
Mouse fibroblasts transformed with this clone bind serotonin agonists and antagonists and exhibit an increase in intracellular Ca2 + concentrations in response to serotonin.
Mouse fibroblast cells expressing HP1alpha, the human version of heterochromatin protein 1a.
The conversion rate was lower, but the induced neurons seemed just as much like their natural counterparts as those produced from embryonic mouse fibroblasts.
Having shown that it's possible to directly reprogram mouse fibroblasts (in a dish and in adult hearts) and also human heart fibroblasts in a dish, Dr. Srivastava's group is testing the recipe in pigs, whose heart size and physiology is closer to our own.
Mouse fibroblasts, however, had no effect on the cancer cells.
In a study published recently in the journal Carbon, the team grew human and mouse fibroblast cells (cells involved in wound healing) on flat graphene sheets and on wrinkled ones.
The study demonstrates that, when added to the Yamanaka cocktail to reprogram mouse fibroblasts, the duo TH2A / TH2B increases the efficiency of iPSC cell generation about twentyfold and the speed of the process two - to threefold.
The specific fibroblasts used were embryonic mouse fibroblasts.
Cell Stem Cell «Recently three different studies were published demonstrating that mouse fibroblast (skin) cells can be directly reprogrammed to behave like embryonic stem cells.»
The researchers first found four small molecules that could induce immature neurons from mouse fibroblasts, but these were inefficient.