Similar findings were present in the cerebral cortex and other regions of the brain in these animals and also found in several
other mouse models of diabetes.
«Natural killer cells help to drive inflammation, insulin resistance: Study
in mouse models of diabetes identifies key immune mechanisms in abdominal fat.»
In addition to looking
at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.
To account for the different responses to various wound types
among mouse models of diabetes, Mustoe and his team assessed how these models respond to three major wound types.
Scientists in the laboratory of C. Ronald Kahn, M.D., head of Joslin's Integrative Physiology and Metabolism research section, found that brain cholesterol synthesis, the only source of cholesterol for the brain, drops in
several mouse models of diabetes.
The Joslin researchers then transplanted these modified human diabetic cells into wounds
in mice models of diabetes that also had suppressed immune systems so that they didn't reject human cells.
Dr. Goldberg and his team made their discovery by studying two
mouse models of diabetes.
After colleagues at Sanofi provided an investigational compound that activates PKM2, the team showed that this compound could stop abnormalities in mouse podocytes both in cell culture and in two
mouse models of diabetes.
Excitingly, when transplanted into
a mouse model of diabetes, the pancreatic bud allowed for the rapid normalization of body weight and blood glucose levels.
The two labs are now collaborating on further studies of the new enzymes — and the potential benefits of inhibiting them — in
mouse models of diabetes, inflammation and autoimmune disease.
«To determine whether TSP2 contributes to delayed wound healing, we genetically removed TSP2 from
a mouse model of diabetes and observed improved wound healing.