Sentences with phrase «mouse strains»

Currently, it takes up to 10 months — and as much as $ 100,000 — to develop a knockout mouse strain.

Different mouse strains, which have different genetic backgrounds, show different levels of preference for addictive substances.

This system could be used in combination with hundreds of existing mouse strains that have been engineered to express known cancer genes, allowing researchers to study more thoroughly the interactions of multiple genes.

She has generated multiple genetically altered mouse strains to facilitate lung stem cell analysis in vivo.

The database obtained in many mouse strains will permit to compare tested animals to database in order to reduce the number of control animals used.

His lab eventually sold mouse strains all over the country.

All welfare information associated with a particular mouse strain and any specialist care required is provided to other scientists via public databases.

However, researchers have only limited possibilities to study what exactly happens when the protein is missing because it is very difficult for them to breed the necessary mouse strains.

• ES cell line purity verification In addition to mouse strain purity verification, the facility provides genetic screening of ES cell lines used for gene targeting experiments.

The researchers made use of 2 genetically unique mouse strains that show distinctive behavioral responses to chronic stress to try to find genetic mechanisms linked to vulnerability to stressful events.

When using the 129S8 Inbred mouse strain in a publication, please include JAX stock # 012809 in your Materials and Methods section.

The workshop is offered to teach methods in cryopreservation for banking of mouse strains used in research, including inbred, transgenic and targeted mutant strains.

In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.

The European Mutant Mouse Archive (EMMA) welcomes submission of mutant mouse strains from all over the world, archives free of charge and facilitates global distribution.

Humans might vary more in their response to the drug than the inbred mouse strain used in these experiments, she points out.

Additional experiments with several other mouse strains suggested that a gene called Ets2 — whose human counterpart is triplicated in people with Down syndrome — accounts for much of the protection.

Our primary experimental approach involves creation of engineered mouse strains with informative genetic mutations, characterizing these mice and their cells to elucidate molecular mechanisms underlying cancer phenotypes, and verifying these mechanisms in human cancer patient specimens.

This latter effect reduces removal of cholesterol and increases cholesterol levels (in particular, non-HDL-C) which allows atherosclerosis induction to occur in susceptible mouse strains.

Another of Woo's experiments involved a PAH - deficient mouse strain developed by William Dove and colleagues at the University of Wisconsin in Madison.

The same clearing and imaging pipeline is applied to a transgenic mouse strain where fluorescent proteins are expressed under the promoter of the immediate early gene c - fos (TRAP mice, Guenthner et al. 2013).

So far EMMA has archived over 2500 mouse strains generated using the EUCOMM / KOMP targeting strategies.

«We have demonstrated the significance of this link in a mouse model system, based on the use of a miR - 34a - deficient mouse strain that we had generated.

Mouse strains submitted for archiving are evaluated by EMMA's external Evaluation Committee.

The data demonstrated that an mRNA vaccine encoding for Zika prM - E protected against Zika virus in three different mouse strains after two doses: prime plus boost.

When using the A / J mouse strain in a publication, please include JAX stock # 000646 in your Materials and Methods section.

For their experiments, the researchers created hybrids of two genetically distinct mouse strains with a fully sequenced genome, allowing gene variants to be clearly assigned to the maternal or paternal allele.

The new mouse strains are ideally suited to settle fundamental questions regarding the biology of mast cells and their functions in the immune system.

This suggested that obesity in both obese and db mouse strains resulted from a mutation in a single gene in each case.

By using pharmacological small molecule inhibitors as well as neutrophils from genetically modified mouse strains the team could identify essential receptor and signaling pathways involved in the nicotine - mediated activation of neutrophils.

Next, they confirmed these results in a special mouse strain bred to express HIV / gp120 in its brain.

In order to encourage submission of valuable mouse strains while the Donating Investigator awaits publication of the first paper describing the strain, the submission form includes an option to request Delayed Release.

To address this challenge, the International Mouse Phenotyping Consortium (IMPC) is creating a genome - and phenome - wide catalogue of gene function by characterizing new knockout - mouse strains across diverse biological systems through a broad set of standardized phenotyping tests.

As noted in the JAX ® Mice strain data sheets, the best control for a targeted mutant is the 129 strain used to produce the ES cell line from which the mutant was derived (Simpson et al. 1997; Threadgill et al. 1997).

The addition of mouse strain data is accompanied by changes to the search interface to allow this data to be found but without overwhelming the results in other circumstances.

While it is possible to induce atherosclerosis in some mice, it is important to realize that the presence of cholic acid can influence transcription factors controlling genes involved with regulating lipoprotein metabolism and inflammation, both of which are important in the development of atherosclerosis (16, 17), and can also promote gallstones in certain mouse strains (18, 19).

Cancer is the leading cause of death in the relevant mouse strains» says the specialist in molecular medicine.

In addition, the Merck institute — a nonprofit foundation set up by the giant drug company — is pulling together a committee of six prominent biologists who will select 150 clones for development into mouse strains over the next few years.

Barbara Rehermann and Stephan Rosshart first collected 800 wild house mice (Mus musculus domesticus) in the Washington, D.C., metro area, and compared their DNA and gut bacteria both with a lab mouse strain and with wild mice from all over the world.

While trying to create better mouse strains for studying human diseases, she and other researchers may have inadvertently stumbled upon genes that render hybrids as dead ends.

Even though the work was not hard for me — maintaining mouse strains, isolating DNA, PCR, primer design, preparing to make a new gene construct, northern blots — it took me a lot of time to translate so many English terms into Chinese in my mind.

It is now possible to introduce mice strains (known as «knockout mice») in which specific genetic modifications can be activitated at specific times, or in specific cells or organs.

The unit provides genetic testing services using a combination of both microsatellite and single nucleotide polymorphism (SNP) panels for characterizing and selecting breeders in a wide variety of inbred mouse strains subsequently used for the generation of congenic animals.

As CRISPR / Cas9 will work in most mouse strains, new mutations can be directly generated in a genetic background of choice.