Sentences with word «myc»

«Furthermore, CSN6 also affects the expression of Myc in tumors.»

Trotman collaborated with Dana - Farber's Professor James Bradner to treat these very sick animals with a newly discovered drug called JQ1 that lowers the amount of Myc in cells.

They found that prostate tumors could be driven to metastasize simply by increasing the amount of Myc protein.

Research from Karolinska Institutet in Sweden suggests that the expression of the so called MYC gene is important and necessary for neurogenesis in the spinal cord.

«Cancer doesn't sleep: MYC oncogene disrupts clock, metabolism in cancer cells: Findings inform time - dependent treatment for reducing side effects, increasing effectiveness of cancer medications.»

So - called Myc inhibitors are extremely potent in a petri dish.

The focus then moved to the Leeds researchers ESR05 Joanna Pozniak, and ESR06 Sathya Muralidhar, who gave back to back presentations on MYC expression and smoking as modulators of immune response to melanoma and the protective effect of vitamin D receptor (VDR) expression on melanoma survival associated with increased an anti-tumour immune response.

Following up on that observation, Guccione and his colleagues from A * STAR decided to investigate which gene sets are turned on by MYC in mouse models of lymphoma.

Small molecule MYC inhibitor conjugated to integrin - targeted nanoparticles extends survival in a mouse model of disseminated multiple myeloma.

A new study from the University of Wurzburg, Germany and the University of Helsinki, Finland, suggests that Myc cancer gene makes cells to commit suicide by repressing life supporting «well - being» genes.

Targeting MYC as a Therapeutic Intervention for Anaplastic Thyroid Cancer JCEM March 28, 2017 Keisuke Enomoto, Xuguang Zhu, Sunmi Park, Li Zhao, Yuelin J. Zhu, Mark C. Willingham, Jun Qi, John A. Copland, Paul Meltzer, and Sheue - yann Cheng Anaplastic thyroid cancer (ATC) is one of the most aggressive cancers in humans.

This suggests that in the future medicines that block MCL - 1 could be effective in treating cancers expressing high levels of MYC with tolerable side - effects on the body's normal cells,» she said.

«For a long time now, the entire field was collecting data on MYC, LIN41, and other genes and proteins without knowing what most of it meant,» said Yamanaka, who is also director of the Center for iPS Cell Research and Application (CiRA) at Kyoto University, and professor at UC San Francisco.

They found a link between MYC overexpression and the activity of spliceosome - related genes.

A study at The University of Texas MD Anderson Cancer Center led by Mong - Hong Lee, Ph.D., a professor of molecular and cellular oncology, has demonstrated the significance of CSN6 in regulating Myc which may very well open up a new pathway for treating and killing tumors.

«The RapidCaP system has revealed a specific role for Myc as a druggable driver of metastasis in prostate cancer,» says Trotman.

Dr Kelly said the research built on more than three decades of work at the institute into how MYC drives cancer development and how the survival of normal and cancerous cells is regulated.

«RapidCaP, a novel GEM model for analysis and therapy of metastatic prostate cancer reveals Myc as a driver of Pten - mutant metastasis» appears online in Cancer Discovery on January 21, 2014.

When safely inside, the drug is enzymatically freed to do its job, blocking Myc from activation.

For example, in colorectal cancer lab models, where a mutation in the beta - catenin gene drives MYC to cancerous levels, eliminating PVT1 from these cells made the tumors nearly disappear.

To create a model of clear cell kidney cancer, they activated MYC and deleted two other genes.

For example, in the mouse model of Notch - induced T - cell leukemia, the Penn group previously found that the difference between inducing a T cell tumor or not is a doubling of Myc transcription by Notch.

At Berkeley Lab, Yaswen engineered normal breast cells, donated by patients who had undergone breast - reduction surgery, to carry a molecular construct that caused the cells to express MYC only when a particular chemical compound was applied.

Our Executive Chef's mastery in creating delicious meals is what makes dining at MYC a unique, worthwhile and memorable experience.

«We are excited by the work of Dr. Pourdehnad and colleagues and believe these results are an important advance in understanding the role of myc pathway dysregulation in multiple myeloma, and ultimately allow for the development of therapeutic strategies to address it,» said Jeffrey Wolf, MD, a UCSF blood disorder specialist and director of the Stephen and Nancy Grand Multiple Myeloma Translational Initiative at UCSF, a sponsor of the research.

Unrestrained myc activity is a major player in many cancers, including cancers of the lung, colon, breast, brain, prostate and blood.

The new findings suggest that Myc makes cancer cells vulnerable to cell death by repressing well - being genes, which are essential for maintaining the life of the cells.

«The discovery of this partnership gives us a stronger understanding of how MYC amplification is fueled.

In addition to its role in metabolic pathways, MYC also works directly on damping BMAL1 in its tumor - suppressor role via spurring increased REV - ERBα activity.

Why then Myc oncoprotein transformed cells succumb to ATP deprivation?

They found that deregulated expression of MYC disrupts the molecular clock in cell lines by directly inducing REV - ERBα to dampen expression and oscillation of BMAL1.

It had not previously been viewed as a weapon against myc - driven tumors, according to the UCSF researchers.

MYC binds to active regulatory elements in the genome and broadly amplifies gene expression, leading to rampant cell growth.

They knew that by adding MYC, they could reprogram cells 10 percent more efficiently.

Again, c - Myc seems to be the key to I - BET - 762's success.

They discovered that MYC helps cells get around a significant roadblock in the process.

Katrin Wiese explains, «Our mutant Myc turned on genes without a hitch but it had difficulties to turn genes off.

«We found that PIM1 is indeed highly upregulated in these more aggressive breast cancers that have high MYC expression,» Goga said, «and that patients with high PIM1 tend to do more poorly.»

A widespread cancer - causing protein called MYC promotes the growth of tumor cells in part by ensuring that RNA transcripts are properly spliced, according to latest work from A * STAR researchers.

In this case, myc overexpression represses miR - 23, which normally binds to the 5 ′ - UTR of the glutaminase mRNA leading to its degradation [106].

A team of researchers from the University of Wurzburg, Germany, and the University of Helsinki, Finland, discovered that searching Myc motivated killer genes is akin to barking up the wrong tree.

While Spaghetti Monster RANbody detection with a directly labeled anti-HA or - MYC antibody is less sensitive than HRP RANbody detection, it is approximately as sensitive as detecting the same antigen with a standard primary / labeled secondary antibody.

«One of the major and immediate downstream effects of myc activation is a dramatic increase in the capacity of affected cells to make protein,» Ruggero said «This, in turn, leads to increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal cells into tumor cells.»

ReNeuron developed cells for brain damage by splicing their modified c - myc into human fetal brain tissue obtained from a U.S. cell bank.

«Because MYC is turned on in many other cancers, these results suggest that shutting down the mitochondria must be a very important event in kidney cancer,» Semenza notes.

«Given everything we thought we knew about MYC and LIN41 at the time, we couldn't comprehend how these genes were so beneficial in somatic cell reprogramming, but absolutely useless in tumor reprogramming.

But we also know that MYC does not amplify alone.

Abnormal myc in cancer often is associated with poor treatment outcomes, including death.

We will be very interested in determining whether these compounds could be used to treat MYC - driven cancers,» Professor Strasser said.