Sentences with word «nonobese»

Systemic delivery of TNF - related apoptosis - inducing ligand (TRAIL) elevates levels of tissue inhibitor of metalloproteinase - 1 (TIMP - 1) and prevents type 1 diabetes in nonobese diabetic mice.

Effect of calorie restriction on the free - living physical activity levels of nonobese humans: results of three randomized trials.

We investigated the relationship between multiple lifestyle changes, both independently and jointly, and long - term weight gain in nonobese women and men participating in three separate, prospective studies.

Since the unrelated NGT subjects have a broad BMI range, we further examined the impact of obesity on the expression of these six genes by comparing nonobese and obese NGT subjects.

Gender factors affect fatty acids - induced insulin resistance in nonobese humans: effects of oral steroidal contraception

Frankenfield D, Roth - Yousey L, Compher C. Comparison of predictive equations for resting metabolic rate in healthy nonobese and obese adults: a systematic review.

One of the most popular models is the immunodeficient nonobese diabetic severe combined immunodeficiency (NOD scid) gamma (NSG) transgenic mouse line, which can be endowed with a humanized immune system using CD34 + hematopoietic stem cells.

One French study involving nonobese diabetics found that a version of a gene for a protein that transports zinc in the pancreas increased the risk of this disease.

The physiological basis of this variation was investigated by measuring changes in energy storage and expenditure in 16 nonobese volunteers who were fed 1000 kilocalories per day in excess of weight - maintenance requirements for 8 weeks.

The IL - 1ß Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice.

RESEARCH DESIGN AND METHODS Subjects (n = 54) were given a high - fat meal (75 g fat, 5 g carbohydrate, 6 g protein) after an overnight fast (nonobese control [NOC]: age 39.9 ± 11.8 years [mean ± SD], BMI 24.9 ± 3.2 kg / m2, n = 9; obese: age 43.8 ± 9.5 years, BMI 33.3 ± 2.5 kg / m2, n = 15; impaired glucose tolerance [IGT]: age 41.7 ± 11.3 years, BMI 32.0 ± 4.5 kg / m2, n = 12; type 2 diabetes: age 45.4 ± 10.1 years, BMI 30.3 ± 4.5 kg / m2, n = 18].

In fact, insulin resistance is present in ∼ 25 % of nonobese people with normal glucose tolerance (30).

We recently investigated (64) the effect of dietary chromium supplementation on glucose and insulin metabolism in healthy, nonobese cats.

And if you doubt these two American studies, just consider Australian research that found almost one in every seven obese men could benefit from testosterone replacement, a rate more than four times higher than in nonobese men.

Rigid vs. flexible dieting: association with eating disorder symptoms in nonobese women.

The RR of excess neonatal weight loss associated with delayed OL was similar and significant in both nonobese and obese women (Figure 2).

For their study, the researchers recruited 16 nonobese, relatively sedentary people, and for 8 weeks made sure that these 12 men and four women consumed an extra 1000 calories per day — an experience the volunteers described as 2 months worth of Thanksgiving meals.

Because PD - L1 / programmed cell death (PD - 1) deficiency accelerates development of diabetes in mouse models, Nasr et al. hypothesized that a defect in the PD - L1 / PD - 1 pathway may underpin the hyperglycemia observed in the nonobese diabetic (NOD) mouse model.

'' (as the two independent demonstrations that resveratrol does not extend lifespan in nonobese, wild - type mice over a wide range of doses)» - Michael

And the claim typically persists for decades once widely - cited, despite the best efforts of serious investigators to critique weak methodologies and flawed interpretation, or even robust demonstrations of a null effect in healthy animals (as the two independent demonstrations that resveratrol does not extend lifespan in nonobese, wild - type mice over a wide range of doses).»

Nonobese subjects exhibit glucometabolic sex differences only in the NGT group, where women are more sensitive than men (Figure 5)(200).

Continuous lines represent the normal metabolic condition (NGT) in both nonobese and obese males and females, ie, for declining insulin sensitivity, there is an increase of insulin secretion to compensate for insulin resistance, maintaining NGT (200).

In general, the «good» area is that above the curves for the nonobese subjects, whereas the «bad» one is below and especially in the low left corner characterized by low insulin sensitivity and inadequate secretion.

The nonobese diabetic (NOD) mouse is a common model used for studying treatments for diabetes.

Using a technology that combines RNA interference, a method to silence gene expresson, with lentiviral transgenesis, a method to genetically modify animals, the scientists can manipulate gene activity in the most widely used mouse model for type 1 diabetes, the nonobese diabetic mouse (NOD).

Nonobese diabetic / severe combined immunodeficient (NOD / SCID) mice were initially purchased from The Jackson Laboratory, and the breeding colonies were established in our animal facility (27 — 29) and maintained in standard conditions according to the institutional guidelines.

Studies show that obese men have more estrogen than nonobese men.

Ibanez L, Potau N, Marcos MV, de Zegher F. Treatment of Hirsutism, Hyperandrogenism, Gligomenorrhea, Dyslipidemia, and Hyperinsulinism in Nonobese, Adolescent Girls: Effect of Flutamide.

To determine whether the same phenomenon occurred when vitamin D was ingested orally, obese and nonobese subjects were challenged with an oral dose of 50000 IU vitamin D2.

It is possible that the subcutaneous fat, which is known to store vitamin D3, sequestered more of the cutaneous synthesized vitamin D3 in the obese than in the nonobese subjects because there was more fat available for this process.

There was no relation between basal vitamin D2 concentrations and 25 (OH) D. Peak blood concentrations of vitamin D2 were not significantly different between the obese and nonobese subjects.