«NMR Method Can Chase Down Chemical Threats,» described the researchers» use
of nuclear magnetic resonance spectroscopy to clearly distinguish different salt forms of the highly toxic alkaloid strychnine from one another based on the way different counterions such as chloride or sulfate influence the NMR spectra.
Using a technique
called nuclear magnetic resonance spectroscopy, the researchers measured the concentrations of 21 metabolites key to nerve function in the brains of 10 deceased schizophrenia patients and 12 normal human controls.
On the other hand, dynamic nuclear polarization of molecules via nitrogen vacancy centers has important applications in
nuclear magnetic resonance spectroscopy since it would greatly increase the standard sensitivity of current scanners.
Several are targeted toward chemistry instructors at the high school or university level, including sessions on tools for teaching STEM courses in remote locations and the use of web - based molecular modeling or
nuclear magnetic resonance spectroscopy in the classroom.
Subsequent tests of their energy - holding potential, conducted using electrochemistry and
nuclear magnetic resonance spectroscopy, revealed an electrical storage capacity approximately double that of graphite.
Why the drug combination works in resistant CML Why such a combination of the two inhibitor types works in an animal model has now been explained by Prof. Stephan Grzesiek's team at the Biozentrum of the University of Basel and Dr. Wolfgang Jahnke from Novartis, by a structural analysis using
nuclear magnetic resonance spectroscopy (NMR).
The researchers then used an array of analytical tools — including stool and urine analysis, flow cytometry, light microscopy,
nuclear magnetic resonance spectroscopy, and 16S rRNA analysis — to observe the wide - ranging effects of this sequential co-infection.
Using
nuclear magnetic resonance spectroscopy, two teams working with the Göttingen - based scientists Markus Zweckstetter and Stefan Becker have now shown the complex three - dimensional structure of the protein «at work» in atomic detail.
We used Fourier - transform ion cyclotron resonance mass spectrometry and
nuclear magnetic resonance spectroscopy to show that a sulfilimine bond -LRB-- S = N --RRB- crosslinks hydroxylysine - 211 and methionine - 93 of adjoining protomers, a bond not previously found in biomolecules.
The approach, called solid - state
nuclear magnetic resonance spectroscopy, delivers images similar to MRI, but with key differences.
Using a refined procedure of solid - state
nuclear magnetic resonance spectroscopy (solid - state NMR), they managed, for the first time ever, to identify the sites in the alpha - B - crystallin that attach to the beta - amyloid.
When Daly's team subjected the compound to infrared and
nuclear magnetic resonance spectroscopy (NMR), they found that it consists of a pyridine ring with a chlorine atom attached (see Diagram).
Other students, using chromatography and
nuclear magnetic resonance spectroscopy, for instance, are studying complex mixtures like meat and vegetable stocks.
Kotru's team instead tried a more varied approach, called Raman adiabatic rapid passage, applying laser pulses of changing intensity and frequency — a technique that is also used in
nuclear magnetic resonance spectroscopy to probe features in individual molecules.
For each, they tried to clone the gene and express it in a bacterium, purify and crystallize the protein, and determine its structure through x-ray crystallography or
nuclear magnetic resonance spectroscopy.
Only solid - state
nuclear magnetic resonance spectroscopy (solid - state NMR) is capable of offering a view at the atomic level in this case.
In the past scientists mainly used X-ray crystallography and
nuclear magnetic resonance spectroscopy.
This was made possible by a combination of
nuclear magnetic resonance spectroscopy (NMR) and electron paramagnetic resonance spectroscopy (EPR), two procedures that make it possible to characterise the structural configuration of a protein at atomic resolution.
The research team used a combination of mass spectrometry and
nuclear magnetic resonance spectroscopy to form a holistic picture of what's happening inside the competitor algae.
X-ray crystallography and, more recently,
nuclear magnetic resonance spectroscopy are the most common tools to see how the amino acids in a protein chain arrange themselves based on their attractive and repulsive energies, but they say nothing about the forms the proteins may take along the way, Onuchic said.
Using
nuclear magnetic resonance spectroscopy, the researchers examined how the protein organised itself structurally in relation to the vesicles.
Shaw and Dr. Molly O'Hagan conducted experiments using
nuclear magnetic resonance spectroscopy to examine the three isomers.
The king and queen of protein structure determination have, for years, been X-ray crystallography and
nuclear magnetic resonance spectroscopy.
To see if their approach worked, the team examined the healed material using
nuclear magnetic resonance spectroscopy and other tools at PNNL's Physical Sciences Laboratory along with the helium ion microscope at EMSL, a U.S. Department of Energy Office of Science user facility.
The experiments will be done using EMSL resources, including atomic force microscopy,
nuclear magnetic resonance spectroscopy, infrared spectroscopy, and x-ray diffraction.
Currently, they are measuring the rotational motion of solvent molecules, solute molecules, and combinations of solutes and solvents using
nuclear magnetic resonance spectroscopy.
The technology brings together the power of
nuclear magnetic resonance spectroscopy, which yields a remarkable peek into molecular interactions, and the ability to re-create the extreme conditions found on the tundra, in the deep ocean, or underground — conditions relevant to some of the biggest questions that scientists at DOE laboratories such as PNNL ask.
In 1 sentence: PNNL scientists removed a limitation of
nuclear magnetic resonance spectroscopy to enable studies never before possible under the extreme conditions found in nature.
Keywords: Chromatography, Cloning, Electrophoresis, Filtration, Gas chromatography, Gel electrophoresis, High performance liquid chromatography, Microarray Analysis,
Nuclear magnetic resonance spectroscopy, PAGE, Polymerase chain reaction, Polymerase chain reaction - quantitative, Purification, Reversed - phase chromatography, Separation, Sequencing, Solvents
The Georgia Tech researchers went after all the chemicals at one time, the whole haystack, using mass spectrometry and
nuclear magnetic resonance spectroscopy.
Fawzi, lead author Kathleen Burke, and their co-authors used
both nuclear magnetic resonance spectroscopy, which can define the structure of biomolecules with atomic resolution, and fluorescence microscopy to make their observations about the perpetually unstructured lives of FUS proteins and their droplet - like huddles.
Not only did he excel in academic work, winning the 2002 Nobel Prize in Chemistry for his advancement of
nuclear magnetic resonance spectroscopy, but Wüthrich was also an avid sportsman.