Sentences with phrase «nuclear reprogramming»
"Nuclear reprogramming" refers to a scientific process that can change the specialization or function of a cell by altering its genetic instructions. It involves resetting the cell's identity to an earlier stage, allowing it to potentially become a different type of cell, with different characteristics or abilities. Full definition
Fibroblasts that already carry the Oct4 transgene can be reprogrammed with fewer factors, facilitating the study of nuclear reprogramming [19].
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Elucidating the role of telomerase and telomeres in adult stem cell biology and in nuclear reprogramming of differentiated cells to iPS cells.
«The study has resulted in the redefinition of our understanding of how nuclear reprogramming affects gene expression in extraembryonic tissues of cloned cattle embryos, and the exquisite communication between clones and their recipient mothers.»
The ultimate goal of our laboratory is to generate ES - like cells directly from somatic cells by nuclear reprogramming... which converts adult cells back into embryonic state.
Recently, Hochedlinger has been using iPS cells as a tool for understanding how nuclear reprogramming works.
Along with researchers studying nuclear reprogramming and physicians who developed a revolutionary leukemia drug, New York City Mayor Michael Bloomberg won a public service award from the Lasker Foundation today.
Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type.
This article provides some background to this field, a discussion of mechanisms and efficiency, and comments on prospects for future nuclear reprogramming research.
John Gurdon of the University of Cambridge in the United Kingdom and Shinya Yamanaka of Kyoto University in Japan will receive the Albert Lasker Basic Medical Research Award for their work on nuclear reprogramming.
Alison Murdoch of the Newcastle center noted that crucial knowledge is still lacking on what constitutes a «good» egg, on «what is the appropriate activation signal» for the oocyte, and on how long nuclear reprogramming takes.
The 2009 Albert Lasker Basic Medical Research Award honors two scientists for their discoveries concerning nuclear reprogramming.
Cooke and his colleagues discovered that reactive oxygen species (ROS, also known as oxygen - derived free radicals), play a critical role in nuclear reprogramming.
Taken together, the data describe the first genuine mouse iPS cell lines generated on human feeder cells without exogenous LIF, providing a reliable tool for understanding the molecular mechanisms of nuclear reprogramming.
Both studies hinge on the concept of nuclear reprogramming, or removing the molecular changes that keep adult DNA from returning to the embryonic state.
The primate - specific noncoding RNA HPAT5 regulates pluripotency during human preimplantation development and nuclear reprogramming.
«Dolly the Sheep told me that nuclear reprogramming is possible even in mammalian cells and encouraged me to start my own project, wrote Yamanaka, who splits his time between the University of California, San Francisco, and the Center for iPS Cell Research and Application (CiRA) at Kyoto University in Japan, which he directs.
«Nuclear Reprogramming in Cells,» by J.B. Gurdon and D.A. Melton, Science, Dec. 19, 2008.
Thus, the study, for the first time, reports mouse iPS cell lines generated on human feeder cells, providing a reliable tool for further dissecting the molecular mechanisms of nuclear reprogramming.
The Cas9 / gRNA - modified fibroblasts were subjected to nuclear reprogramming by somatic cell nuclear transfer, resulting in live - born goats carrying single - gene mutation.
A brief history of stem cell research serves as an introduction, followed by coverage of stem cell fundamentals; chapters then explore embryonic and fetal amniotic stem cells, adult stem cells, nuclear reprogramming, and cancer stem cells.
His discoveries ignited the entire field of nuclear reprogramming and allowed all subsequent work to unfold.