Aside from the variation of paracrine factors between male and female cells, the team also found important differences in organization, distribution and morphology
of actin filaments in male and female hAMSCs.
She wrote her dissertation on pollen sterility in petunias, but she also studied cell structure, which led her back to animals and a postdoc at the Scripps Research Institute in San Diego, California, where she studied a protein on the
ends of actin filaments.
Growth of lamellar
networks of actin filaments after the addition of the new compounds (compare the cell contours on the left and right).
The scientists propose that Src42A — a protein that belongs to the family of kinases that regulates the
structure of the actin filament — is one of the main contributors to this system.
Inside the epithelial cell, the tail of E-cadherin binds to a protein called α - catenin, which recruits other proteins that spur assembly and
disassembly of actin filaments and is absolutely critical for strong adherence between epithelial cells.
Beads coated with Arp2 / 3 - activating proteins can induce two distinct types of actin organization in cytoplasmic extracts: (1) comet tails or clouds displaying a dendritic
array of actin filaments and (2) stars with filament bundles radiating from the bead.
He doesn't know where he's going, but his built - in bias to walk forward eventually gets the vesicle to its destination at the
end of the actin filament.
A ring
composed of actin filaments and myosin motor proteins pinches the cell apart, producing two daughter cells with equal amounts of cellular components.
Derived from supramolecular chemistry [4], the new compounds synthesized by the researchers have original properties: within several minutes, they bring about the growth of lamellar
networks of actin filaments.
While
some of these actin filaments appear to completely stable, providing a framework for the cell, others are more dynamic, allowing the cell to respond rapidly to changes in its environment.