Sentences with phrase «of advanced melanoma»

A Phase 2 clinical trial led by Ludwig Harvard's Stephen Hodi and Ludwig Memorial Sloan Kettering (MSK)'s Jedd Wolchok has found that the combination of two immunotherapies for first - line treatment of advanced melanoma induces better responses and far longer progression - free survival than giving one of those drugs alone.

Approximately 50 percent of advanced melanoma tumors are driven to grow by the presence of BRAF mutations and another 20 percent by the presence of NRAS mutations.

About half of all advanced melanomas have a mutation in a gene called BRAF which drives the proliferation of the cancer.

«It was approved in 2011 for first - line treatment of advanced melanoma in the US and Europe.

In the current study, Lu and her colleagues show that a protein complex named cyclin B1 / cdk1, which is expressed at high levels in the cytoplasm of advanced melanomas, induces a pair of precise chemical modifications on iASPP to activate the protein.

Of the 1483 patients in these KEYNOTE trials who had other forms of advanced melanoma and who received at least one dose of pembrolizumab, 33 % responded to the treatment, 72 % were still alive without their disease progressing and the median (average) overall survival time was nearly two years.

According to Herlyn, these slow - growing JARID1B cells represent only one to five percent of the cells in a tumor, yet readily divide into the fast - growing cells that are the hallmark of advanced melanoma.

They say their findings, being presented June 2 at the 50th annual meeting of the American Society of Clinical Oncology (ASCO), offered several clinical insights that could lead to different treatment strategies and perhaps influence staging of advanced melanoma.

«Metastatic brain tumors — often from lung, breast or skin cancers — are the most commonly observed tumors within the brain and account for about 40 percent of advanced melanoma metastases.

Importantly, mutations in the BRAF gene that are seen in more than half of advanced melanomas were absent in mucosal melanoma, explaining the ineffectiveness of BRAF - targeted treatments like vemurafenib.

Moffitt Cancer Center researchers have laid the groundwork for a revolutionary new combination therapy for the treatment of advanced melanoma — melanoma that can not be removed surgically or has spread to other areas of the body.

The FDA approved it last year for the treatment of advanced melanoma, and we think it can help overcome the resistance that we've seen to pembrolizumab.

T - VEC, recently approved for the treatment of advanced melanoma, is an oncolytic herpes simplex virus type 1 engineered to replicate selectively in tumor cells and express human granulocyte - macrophage colony - stimulating factor.