The phenomenon of collective cell migration has been observed in the
process of animal development, the healing of wounds, and cancer cell invasion.
The fruit fly Drosophila melanogaster has emerged as a key model system for elucidating the genetics and molecular
biology of animal development.
The work is significant because it lays the groundwork for the development of quantitative
models of animal development, enabling the use of mathematical tools more commonly associated with the physical sciences to be applied in biological studies.
Not restricted to its spiny namesake, this signaling pathway, which is a key
regulator of animal development, is present in all bilaterians (or animals that are bilaterally symmetrical — which is most animals, including humans).
FP timers should therefore find use in
studies of animal development where events like the patterning of nascent tissues and the formation of limbs are correlated with changes in gene expression.
«These studies show that zebrafish, an animal that is frequently used to study the
genetics of animal development, can also serve as a tool to uncover in systematic fashion the functions of lincRNAs,» says Whitehead Member David Bartel, who is also a Howard Hughes Medical Institute investigator and a professor of biology at MIT.