Sentences with phrase «of apoptosis»

Inecalcitol, an analog of 1,25 D 3, displays enhanced antitumor activity through the induction of apoptosis in a squamous cell carcinoma model system.

Activation of ERK1 / 2 triggers G2 checkpoint which is considered protective from radiation - induced cell death [8, 9], while activated AKT is known to promote DNA repair and inhibition of apoptosis induction [10].

Previously, Jonathan Tilly, a reproductive biologist at Massachusetts General Hospital in Boston, found a striking correlation between high levels of a protein called Bax (a key regulator of apoptosis) and cell death in healthy ovaries.

Control of the activation of apoptosis is important both in development and in protection against cancer.

Morphologic examination of the Hoechst - stained cell preparations at 16 hours after treatment with 20 nmol / L rapamycin showed morphologic evidence of apoptosis, such as nuclear condensation and fragmentation in ALCL cells (A, bottom right).

SZ - 685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt / FOXO pathway.

This is achieved via an IL -22-mediated increase in proliferation and inhibition of apoptosis of epithelial cells and stem cells [22 — 24].

Plasma membrane integrity and the display of phosphatidylserine on the plasma membrane's extracellular face are both hallmarks of apoptosis, and are used in this kit to distinguish apoptosis from necrosis.

Using tumor samples from the Women's Healthy Eating and Living clinical trial, researchers identified stem - like tumor cells as being characterized by low levels of the molecule p53 upregulated modulator of apoptosis (PUMA).

Mammalian cells treated with Mcf1 also display key features of apoptosis which is putatively mediated by a BH3 - like domain and involves the mitochondrial pathway [24], [25].

In addition, their sperm motility was 25 % to 35 % lower, and the cells within the testes underwent higher rates of apoptosis — a form of cell death.

The benzamidazole mebendazole significantly inhibited growth of adrenocortical carcinoma cells, both in vitro and in vivo, the effects being due to induction of apoptosis [19].

In the past year, the laboratory of Dr. Marassi made significant progress on the understanding of the mechanism of apoptosis regulation by BCL - 2 family proteins, and in the development of robust computational methods that enable membrane protein structure calculations in physically realistic environments.

Modulation of apoptosis and immune signaling pathways by the Hantaan virus nucleocapsid protein.

«A third of all cancers are caused by a failure of apoptosis to occur,» he says.

Researchers at Texas Woman's University have shown that a diterpene geranylgeraniol found in linseed oil, Cedrela toona wood oil, sucupira branca fruit oil and more recently, annatto seed oil, suppressed the viability of human DU145 prostate carcinoma cells via cell cycle arrest at the G1 phase and the initiation of apoptosis.

Earlier research had shown that cells surrounding an HIV - infected cell die as a result of apoptosis, or programmed cell suicide, and scientists knew that Nef had a hand in starting that process.

When the team injected the shielded mice with a chemical that blocks cell - to - cell communication before irradiating them, they detected no DNA breaks and the amount of apoptosis decreased more than threefold.

Such obvious differences in morphology suggested that the early freezing effect of Mcf1 is independent of apoptosis but could not rule out a separate more long - term pro-apoptotic effect.

Immunohistochemical staining of rejected human corneal allografts has revealed the presence of apoptosis in corneal stromal cells (5).

Specifically, the inhibitor of apoptosis Bcl - xL (BCL2 - like 1 isoform 1) was overexpressed in the mesenchymal cell population, and this turned out to be necessary and sufficient for chemoresistance.

Stem cells affect the infarcted myocardium via neovascularization, reduction of apoptosis and paracrine effect, they are able to increase myocardial perfusion, inhibit synthesis of pro-inflammatory cytokines (IL6 and TNFα) and promote expression of anti-inflammatory cytokines (IL10) minimizing the necrosis damage caused by local inflammatory reaction.

Furthermore, we show that induction of apoptosis following inhibition of mTOR signaling involved both the extrinsic (c - FLIP) and the intrinsic (MCL - 1 and BCL - 2) apoptotic pathways.

To study the underlying apoptotic mechanisms, expression of apoptosis regulators was assessed after treatment with rapamycin or specific mTOR siRNA.

Karbowski, Mariusz, et al. «Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis.»

What Sattler did focus on at Abbott was the structural biology of apoptosis regulators, such as the Bcl2 protein family.

To explore the physiological significance of unphosphorylated STAT6, the sensitivity of apoptosis of the STAT6 DN cells and STAT6Y641W cells was investigated.

B) Detection of apoptosis in the quail CAM assay.

Despite the dramatic levels of apoptosis observed in wing primordia subject to CIN, the impact on the size of the resulting adult wing is mild.

Read about the monitoring of apoptosis and necrosis in real time using the CLARIOstar's ACU feature, that maintains the appropriate O2 and CO2 environment for cells, while the RealTime - GloTM Annexin V Apoptosis and Necrosis Assay measures cell death using luminescence and fluorescent signals.

Key concepts in apoptosis (programmed cell death) are described, along with more detailed information on the individual parameters of apoptosis.

Dr. Salvesen was recruited to Sanford - Burnham Medical Research Institute in 1996, where he is professor and director of the Apoptosis and Cell Death Research Program and dean of the Graduate School of Biomedical Sciences.

The regression equation for correlation between pSTAT5 and apoptosis was configured to include lesion size (total number of cells in the lesion) along with pSTAT5 % as potential predictive factors of apoptosis, and only pertains to lesions from a single mouse (red).