Sentences with phrase «of brain metastases»

Cumulative Intracranial Tumor Volume and Number of Brain Metastases as Predictors of Developing New Lesions After Stereotactic Radiosurgery for Brain Metastasis.

Several tests in cultured cells indicated that ganciclovir would cause the death of HSV - TK - expressing stem cells, and testing in the mouse model confirmed that administration of the drug after successful treatment of brain metastases successfully eliminated therapeutic stem cells that also expressed HSV - TK.

The genetic similarity of the brain metastases in individual patients suggests that each brain metastasis has developed from a single clone entering the brain.

The subsequent development of brain metastases was studied by researchers.

While neither a drug that targets HER3 nor one that interferes with the interaction between HER2 and HER3 were able to slow the growth of brain metastases, combined treatment with both an anti-HER2 and an anti-HER3 drug significantly slowed tumor growth.

Earlier detection of brain metastases could increase the chances of successful surgical removal of the tumors, says Sanford Simon, whose Laboratory of Cellular Biophysics previously identified the genetic driver behind fibrolamellar.

Before this study was carried out, the extent to which the genetic profiles of brain metastases differ from that of the primary was unknown.

«Genetic screening of brain metastases could reveal new targets for treatment.»

Following early recognition of the importance of the brain as a potential differentiator between the activity of new drugs, the brigatinib trial includes patients with untreated brain metastases, showing a greater than 30 percent decrease in size of brain tumors in 8 of 15 patients with brain tumors greater than 10 mm and disappearance of brain metastases in 11 of 33 patients with smaller lesions only.

Research from McMaster University has identified new regulators of brain metastases in patients with lung cancer.

Stereotactic radiosurgery (SRS) for cancer patients who receive the treatment for brain metastases decreases the likelihood of local recurrence but shows no positive difference in terms of overall survival (OS) or distant brain metastases (DBMs) rates, when compared to observation alone following surgical resection of brain metastases, according to research presented at the 58th Annual Meeting of the American Society for Radiation Oncology (ASTRO).

«HER3 has been associated with treatment resistance in several types of cancer, and our findings indicate that the overexpression of HER3 within the microenvironment of brain metastases reprograms the signaling pathways shut down by HER2 suppression,» says co-first author Ferraro.

Patients were stratified by number of brain metastases (1 vs. 2 - 3), primary cancer type (melanoma vs. other histology) and pre-operative tumor size (less than vs. greater than three centimeters).

«This study is among the first to show that genetic information about tumors can guide decision making for the treatment of brain metastases,» Johung said.

Absence of extracranial metastases, Karnofsky Performance Status score ≥ 90, and no history of TKI therapy before the development of brain metastases were associated with improved survival.

A new study shows that modified neural stem cells can effectively target and inhibit the growth of brain metastases and enhance survival in a mouse model of breast cancer.

However, the study results can not be extrapolated to infer that SRS is the standard for patients with 4 or more metastases or that WBRT no longer has a role in the treatment of brain metastases.»

A pre-surgery tumor size of greater than three centimeters was associated with worse LC, but local recurrence was not significantly affected by the number of brain metastases or the patients» histology or graded prognosis assessments.

[38] A retrospective study of 90 patients with ALK - rearranged NSCLC metastatic to the brain found that OS after the development of brain metastases was still prolonged at approximately 4 years (49.5 months), with patients frequently having multiple opportunities for salvage SRS at recurrence; 45 % of patients on follow - up had progressive brain metastases at death.

Validation of the Graded Prognostic Assessment for Melanoma Using Molecular Markers (Melanoma - molGPA) It has been suggested to replace the diagnosis - specific graded prognostic assessment (DS - GPA, based on performance status and number of brain metastases) for patients with primary malignant melanoma with the new Melanoma - molGPA.

It has been suggested to replace the diagnosis - specific graded prognostic assessment (DS - GPA, based on performance status and number of brain metastases) for patients with primary malignant melanoma with the new Melanoma - molGPA.

In this video, Dr. Patricia Steeg discusses the role of the blood - tumor barrier in both development and treatment of brain metastases.