Sentences with phrase «of breast cancer cells»

They demonstrated that this new molecule can stop the growth of breast cancer cells in laboratory experiments.

In a study, this nutrient was found to have the ability to suppress the growth and proliferation of breast cancer cells.

Breast cancer is caused by a genetic mutation in the DNA of breast cancer cells.

Some claim that it does promote the growth of breast cancer cells, while others say that it can halt the tumor.

Inhibiting Rab11b reduced the invasiveness of a breast cancer cell line, called MDA - MB - 231, that expresses high amounts of Arf6 signaling proteins, the researchers discovered.

This statement is based on two reports showing that soy caused a small stimulation of normal breast cancer tissue and a report that genistein, one of the phytoestrogens found in soy, stimulated the rate of growth of breast cancer cells in mice lacking both their ovaries and a functioning immune system.

Gene therapy delivered directly to a particularly stubborn type of breast cancer cell causes the cells to self - destruct, lowers chance of recurrence and helps increase the effectiveness of some types of chemotherapy, researchers...

Dixon's team also looked at the ability of breast cancer cells to migrate and invade surrounding tissues, with and without Fam20C.

miR - 148a Suppresses estrogen - induced viability and migration of breast cancer cells via inhibition of estrogen receptor a expression.

To directly examine whether ABL kinases play a role in regulating the colonization and survival of breast cancer cells in the bone microenvironment, we injected control or ABL1 / ABL2 knockdown breast cancer cells directly into the tibia of immunodeficient mice.

Our data raise the possibility that inhibition of ABL kinases can increase apoptosis of breast cancer cells and block osteoclast activation, which is required for osteolytic metastasis.

This stage also has two categories, 1A and 1B, based on whether there is any evidence of small clusters of breast cancer cells in nearby lymph nodes.

«Turncoat protein regulates sensitivity of breast cancer cells to drug.»

In a study published in Toxicology and Applied Pharmacology, researchers found that broccoli and watercress suppressed the production of cancer - promoting enzymes known as matrix metalloproteinases, thereby limiting the invasiveness of breast cancer cells.

Studying the drug - responsiveness of breast cancer cells cultured within human osteoblast - derived matrices.

Another study out of Japan found that infrared - induced, whole - body hyperthermia helped strongly inhibit the growth and spread of breast cancer cells in mice, without causing any harmful side effects.

Autocrine / paracrine regulation of breast cancer cell proliferation by growth hormone releasing hormone via Ras, Raf, and mitogen - activated protein kinase.

When testing for HER2, IHC assigns a score of 0 to 3 + to the amount of HER2 receptor protein on the surface of breast cancer cells.

New evidence however is showing that not only is there not a risk, but that soy is actually beneficial in terms of mortality and reducing the recurrence of breast cancer cells.

In contrast, S1P treatment of breast cancer cells does not activate matriptase, and instead these cells constitutively activate the protease.

To gain insight into the signaling pathway (s) required for ABL1 / ABL2 - dependent bone metastasis, we evaluated the consequences of single or double inactivation of ABL1 and ABL2 on the transcriptome of breast cancer cells using next - generation sequencing (RNAseq) analysis (Fig. 6 and fig.

Researchers at Roswell Park Cancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cancer.

The investigators tested a variety of breast cancer cell types, including tamoxifen - sensitive cells that are resistant to the drug lapatinib, another targeted therapy that is used to treat patients with advanced breast cancer whose tumors contain the mutant HER2 gene.

«What began with the question «what makes a particular aggressive form of breast cancer cells keep growing?»

Scientists at the Computational Biology Center in IBM Research provided analytics tools and performed analysis of the data to help tease out the biological mechanisms at play in studying the micro-environment of breast cancer cells.

The identification of patients with high - risk breast cancer is key to knowing whether a patient will require only the removal of the tumor by surgery or whether if she will need additional chemotherapy to make sure the removal of breast cancer cells.

The Arf6 pathway may also boost the drug resistance of breast cancer cells, and Hashimoto et al. found that inhibiting Rab11b, or a component of the Arf6 pathway called EPB41L5, increased the sensitivity of MDA - MB - 231 cells to two different cytotoxic compounds.

Interestingly, Yu and colleagues recently showed that knockdown of KLF4 decreased the proportion of cancer stem cells, whereas overexpression of this gene led to an increase in the cancer stem cell population, suggesting that KLF4 plays a strong oncogenic role in mammary tumorigenesis likely by maintaining stem cell - like futures of breast cancer cells (29).

In support of this notion, KLF4 has been found to be frequently overexpressed in 70 % of breast cancers, and its localization in the nucleus of breast cancer cells has been identified as a marker of aggressive phenotype in early - stage infiltrating ductal carcinoma (30).

Scanning electron micrograph of breast cancer cells interacting with an astrocytes.

Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4 / 6 inhibitor palbociclib, The EMBO Journal (2018).

Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells, making them more aggressive as a result.

Dr. Vines is frequently analyzing models used to understand how CCR7 affects the movement of breast cancer cells and T cell acute lymphocytic leukemia cells.

Matriptase and its cognate inhibitor, HGF activator inhibitor 1 (HAI - 1) colocalize on the cell periphery of breast cancer cells and form stable complexes in the extracellular milieu, suggesting that the inhibitor serves to prevent undesired proteolysis in these cells.

Quantitative proteomics study of breast cancer cell lines isolated from a single patient: discovery of TIMM17A as a marker for breast cancer.

Subpopulations of breast cancer cells sometimes cooperate to aid tumor growth, according to Penn State College of Medicine researchers, who believe that understanding the relationship between cancer subpopulations could lead to new targets for cancer treatment.

«We may have found a root source, maybe the root source, of what ultimately determines the destiny of breast cancer cells — their future benign or aggressive clinical behavior,» says Whitehead Founding Member Robert Weinberg, who is also a professor of biology at MIT and Director of the MIT / Ludwig Center for Molecular Oncology.

Leptin receptor is necessary for pluripotency of breast cancer cells.

Treatment of tumor - bearing mice with GNF5 starting on day 8 after intracardiac injection of breast cancer cells (Fig. 3A) resulted in a significant increase in survival (Fig. 3B) and a decrease in bone metastasis burden as measured by bioluminescence imaging (Fig. 3, C and D).

Therefore, these findings suggest that ABL1 / ABL2 - dependent expansion of breast cancer cells is mediated by factors present in the bone microenvironment.

14/3: 15 Comprehensive genome and transcriptome structural analysis of a breast cancer cell line using PacBio long read sequencing.

The functional data provided from a limited series of breast cancer cell lines does not allow generalizable conclusions to be drawn.