«The comparison of the MRI images from the two mazes reveals which brain regions were specifically contributing to the
formation of spatial memories,» says Svenja Brodt, a doctoral candidate at the Graduate Training Center of Neuroscience and lead author of the study.
They found that, within the first three days of injury, fish in the concussion group were slower to find a school of fish with which they previously swam, a
measure of spatial memory which is impaired in other animal models of concussion and human patients.
«Honeycomb maze offers significant improvement over current spatial navigation tests: Powerful new tool for the
study of spatial memory.»
For his research, Wegman combined data from several studies done by the Radboud University research group Neural
Correlates of Spatial Memory at the Donders Institute for Brain, Cognition and Behaviour.
«Their
loss of spatial memory formation was not a surprise,» said senior co-author Robert Clark, PhD, a professor of psychiatry.
As in the first study, a group of young mice carrying the human gene APOE4 showed cognitive impairment on the behavioral level — in other words, they showed signs of damage on the
level of spatial memory.
Compared to aged vector controls, aged rats overexpressing FKBP1b showed dramatic
enhancement of spatial memory, which correlated with marked reduction of sAHP magnitude.
A powerful new tool for the
study of spatial memory was today described in Nature as a significant improvement over the current gold standard, the Morris Water Maze.
This allowed the researchers to correlate the neural activation associated with the
formation of spatial memories (the locations of the stores) and the recall of episodic memories: (the list of items that had been delivered).