Sentences with phrase «of tumor growth»

The drug resulted in greater than 80 percent decrease in growth of adrenal cancer cell lines as well as inhibition of tumor growth in animal models.

In a mouse model of melanoma, blocking this pathway resulted in reduction of tumor growth.

Over the years, many different mathematical models of tumor growth have been proposed, but determining which is most accurate at predicting cancer progression is a challenge.

According to this hypothesis, cancer stem cells are the main drivers of tumor growth and are also resistant to standard cancer treatments.

It's my position that random genetic mutations of DNA that ultimately lead to the formation of tumor growth would theoretically not have developed apart from the advent of human sin.

The idea has been controversial, but three papers published today report evidence that in certain brain, skin, and intestinal tumors, cancer stem cells are the source of tumor growth.

Practical applications in use include studies of tumor growth in cancer research and locating where viruses and bacteria hide.

Additionally, if there is repeated inflammation at these sites, there is a likelihood of tumor growth which could lead to cancer.

Lower doses of progesterone did not have the same effect, and even stimulated some types of tumor growth.

The time frame and extent of tumor growth are vital pieces of information to relay to your pet's doctor.

As such, mice carrying human tumors can help identify drivers of tumor growth and serve as excellent test subjects for investigating new drugs.

Instead, study findings revealed chromosomal changes occur in short, punctuated «bursts» at the earliest stages of tumor growth.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

Suppression of tumor growth by terbinafine is associated with decreased cholesteryl ester concentrations, restoration of PTEN expression, and inhibition of AKT - mTOR, consistent with blockade of SQLE function.

«The result was an extensive inhibition of tumor growth and prevention of metastasis to the lung in HER2 - positive animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.

«However, we still know very little about the molecular causes of tissue alterations and their effects on the further course of tumor growth.

The study, conducted in mice with an aggressive human brain cancer implanted in their brains, is the first to demonstrate stimulation of tumor growth by brain activity.

When a chemical that inhibits entosis was applied to a line of breast cancer cells, colony formation — an indicator of tumor growth in vitro — increased 10-fold.

BETs have been fast - tracked into clinical trials and have shown impressive slowing of tumor growth in multiple cancer types.

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

Kuang is also involved in efforts to model various aspects of tumor growth and management as part of ASU's efforts on cancer research.

But most importantly, the researchers say, in three laboratory tests of tumor growth, the drug strongly blocked tumor formation in distant metastases and their precursors.

He and his colleagues report online in Nature that in mouse papilloma tumors, a precursor to skin cancer, most of the tumor growth came from a few cells, which in some ways resembled the stem cells that maintain healthy skin.

Scientists hope to target these sites of tumor growth with therapies that can control abdominal tumors and assist anti-tumor immunity.

The combination of tumor growth and chemotherapy led to shrinkage in brain regions that are important for learning and memory.

Using a mathematical modeling approach, scientists have found that certain parameters of tumor growth in mice can predict the effectiveness of drugs that block formation of tumor - nourishing blood vessels.

«Our experiments showed that restoring H19 expression hindered by too much p53 restored «protective differentiation» of osteoblasts to counter events of tumor growth early on in bone cancer,» said co-author, Ihor Lemischka, PhD, Director of The Black Family Stem Cell Institute within the Icahn School of Medicine.

In clinical trials, about 20 percent of breast cancer patients treated with abemaciclib by itself have a significant response to the drug and another 20 to 30 percent have stabilizations of tumor growth, the authors explained.

The cumulative effect of these processes is a halting or reversal of tumor growth.

Many studies in tumor models have forcibly provided 4 - 1BB signals, injecting either agonist antibodies to 4 - 1BB, or transfecting 4 - 1BBL into the tumor cells, also highlighting the stimulatory capability of 4 - 1BB in driving suppression of tumor growth largely through augmenting CTL and NK responses.

The central focus of my future work is to elucidate the mechanisms by which tumorigenesis results in the conversion of TGFβ from a suppressor of tumor formation to a promoter of tumor growth, invasion, and metastasis.

Recent findings suggest that tumor associated stroma is another important regulator of tumor growth and progression which may also modulate the recruitment, activation status and retention of immune cells in the tumor microenvironment.

While pumpkins are a fabulous power food (the carotenoids lutein and zeaxanthin, are believed to help protect against macular degeneration, and alpha - carotene may aid in the prevention of tumor growth), the yogurt used in these muffins also makes them light.

A couple of studies have shown that eating flaxseeds may reduce markers of tumor growth in women with breast cancer, and may also reduce cancer risk (10, 11, 12).

Other compounds in ginger such as zingerone and paradols provide chemopreventive activity which prevents and slows the progression of tumor growth in the following ways: (13)

«We found that two distinct «molecular clocks» were operating at different stages of tumor growth, said Navin.

Silencing of the enzyme stimulated vessel formation, but paradoxically resulted in a profound reduction of tumor growth; an effect that relies on the anti-proliferative nature of the TGFβ signaling pathway, in a largely HIF1α - independent manner (Klotzsche - von Ameln et al., Cancer Res., 2011 and Cancer Biol Ther., 2012).

Model of tumor growth in a rat brain before radiation treatment (left) and after one session of radiotherapy (right).

Infusion of CAR T cells into an immunodeficient mouse model led to inhibition of tumor growth.

This is contradictory to the common concept that cancer cells undergo a series of mutations in the course of tumor growth to acquire the ability to leave the primary site of the tumor and start migrating to other parts of the body.

In patients likely to have surgery, close, active monitoring of small renal tumors confined to the kidneys is associated with low rates of tumor growth or death, according to a study by a researcher at the Icahn School of Medicine at Mount Sinai published in the September issue of The Journal of Urology.

Because Sonic Hedgehog might be an indicator of tumor growth, targeting this protein could be clinically beneficial for choroid plexus carcinoma treatment.

When antibodies and other methods were used to dramatically deplete the supply of Tregs in mice, the researchers saw a dramatic jump in the numbers of activated dendritic cells and CD8 + T cells in pancreatic tumor tissue, as well as a slowing of tumor growth.

«Both the effect on the stimulated immune responses and the consequential suppression of tumor growth are results that would suggest further development and clinical testing.»

«Most importantly, we demonstrated in our study that blocking the pathway resulted in reduction of tumor growth in an experimental model of human melanoma transplanted into mice,» Ballabio said.

Even in the early stages of tumor growth, the microRNA remains active to keep the cancer stem cell population down.

In patients with small renal tumors confined to the kidneys, close, active monitoring, as opposed to immediate surgery, is associated with low rates of tumor growth or death, according to a study by researchers at the Icahn School of Medicine at Mount Sinai and Fox Chase Cancer Center, part of the Temple University Health System, published in the September issue of the Journal of Urology.