Sentences with word «oligomerization»

They are assembled by oligomerization of triple - helical protomers and are covalently crosslinked, a key reinforcement that stabilizes networks.

RIPK2 works in conjunction with NOD1 and NOD2 (nucleotide - binding oligomerization domain) proteins in controlling responses by the immune system that lead to this inflammation process.

The nucleotide - binding oligomerization domain - containing protein 1 (NOD1) polymorphism S7N does not affect receptor function.

Berkeley Lab researchers used structural characterization — both X-ray crystallography and small angle X-ray scattering (SAXS)-- to show that many of the designs adopted the target oligomerization state and predicted structure.

This makes sense as oligomerization is required to marshal the cellular forces needed to deal with these ER problems.

Mutations that abolished CED - 4 oligomerization inactivated its ability to activate CED - 3.

The observation that RNA molecules can catalyze their own oligomerization has possible implications for the evolution of chromosomes and for the replicative cycle of plant viroids and virus - associated RNA's.

Paladino, Simona, et al. «Protein oligomerization modulates raft partitioning and apical sorting of GPI - anchored proteins.»

Not only does their work demonstrate that scientists have a basic understanding of what determines oligomerization, it also shows that they can design proteins with tunable shape, size, and symmetry for a variety of biological applications.

In these fusions, ultraviolet light exposure caused oligomerization of the Dronpa domains thereby occluding the enzyme active site and shutting off the enzyme.

Structural determinants of human proton - coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6

Later exposure to cyan light stopped Dronpa oligomerization and turned the enzymes back on.

Activation of nuclear factor κ - light - chain - enhancer of activated B cells (NFκB) proceeds through multiple pathways involving tumor necrosis factor receptor 1 (TNF - R1) and pathogen - recognition receptors, such as Toll - like receptors (TLRs)(Orlowski and Baldwin, 2002; Madrid and Baldwin, 2003; Hayden and Ghosh, 2004) and nucleotide - binding oligomerization domain - containing protein 2 (NOD2), an intracellular pattern - recognition receptor.

Oligomerization is different from other self - catalyzed reactions of the intervening sequence RNA in that it involves intermolecular rather than intramolecular recombination, producing RNA molecules that are substantially larger than the original.

This oligomerization induced CED - 3 proximity and competed with CED - 4: CED - 9 interaction.

Thus, the mechanism of control is that CED - 3 in CED - 3: CED - 4 complexes is activated by CED - 4 oligomerization, which is inhibited by binding of CED - 9 to CED - 4.

Sometimes, proteins must be in an «oligomeric» state to be functional, although «oligomerization» of certain proteins can also lead to diseases.

We discovered that levuglandins can greatly accelerate the oligomerization of amyloid beta and that the oligomers so formed are neurotoxic.

A major lab project involves the study of prohormone convertase enzymology and potential dominant negative effects (effects of oligomerization, the role of the inhibitory tail domain, and cellular targeting).

Oligomerization and pore formation by equinatoxin II inhibit endocytosis and lead to plasma membrane reorganization García - Sáez AJ, Buschhorn SB, Keller H, Anderluh G, Simons K, Schwille P.,.

These structures prevent end - to - end interactions that lower the solubility of RiAFP and lead to oligomerization and aggregation.

JAIN, R., et al. «Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells.»

So certain mutations and membrane situations can affect the oligomerization state.

In this case, Tao found that the protein has a distinctive loop that is essential for self - oligomerization and encapsidation of the viral genome into a double - helical hairpin structure.

She then compared the amino acid sequences of the nucleoprotein from different influenza viruses, finding that the oligomerization loop is a well - conserved feature.