Sentences with phrase «on endothelial cells»

Therefore, it would be advisable to test the potential effects of kahweol on endothelial cell apoptosis.

One version seems to paralyze the inflammatory response that should fight the virus off, while the other homes in on the endothelial cells lining the blood vessels, helping the virus infect and damage them.

Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed on endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent blood vessels.

«Most previous studies had focused on the media cells but hadn't spent much time on the endothelial cells, and nobody had shown how the two would interact,» Truskey said.

In the current study, the researchers report that NOTCH1 acts like a sensor on the endothelial cells — the cells that line the valve and vessels — detecting blood flow outside of the cell and transmitting information to a network of genes inside the cell.

Since fish without this mutation are able to do both, the investigators concluded that an interaction between CXCR4 receptors on endothelial cells and the CXCL12b protein expressed by the myocardium regulate the process.

Enhanced CD146 expression has been reported on endothelial cells in intestinal biopsies from patients with inflammatory bowel disease.

The study focuses on endothelial cells, the cells lining the inside of blood vessels in which atherosclerotic plaques develop.

Mechanotransduction The effects of extracellular matrix stiffening on endothelial cell health Cynthia Reinhart - King, Cornell University The effects of membrane cholesterol and extracellular matrix elasticity on vascular smooth muscle cell mechanics and migration Zhongkui Hong, University of South Dakota

Figure 6 shows the effects of 75 µM kahweol on endothelial cell migration, as determined by the «wound healing» assay, after 8 and 24 h of treatment.

Determine the effects of intermittent interactions of antibodies and complement on endothelial cells.

We also demonstrate the inhibitory effect of kahweol on the endothelial cell potential to remodel extracellular matrix by targeting two key molecules involved in the process, MMP - 2 and uPA.

Data obtained on the effects of kahweol on endothelial cell invasion (as determined by a continuous fluorescent assay) clearly show that kahweol induces an anti-invasive effect in HUVEC in a dose - dependent manner (Figure 7).

Shear stress on endothelial cells is a potent stimulus for NO production.

They include its effects on endothelial cell «differentiation» to yield tubular - like structures, endothelial and tumor cell proliferation, apoptosis, and migration, as well as its effects on extracellular matrix remodelling enzyme activities of matrix metalloproteinase - 2 (MMP - 2) and urokinase - type plasminogen activator (uPA).

Since invasion is dependent on extracellular matrix remodeling capabilities, this inhibitory effect strongly suggested that the two key extracellular membrane remodeling enzymes expressed by endothelial cells, namely, MMP - 2 and uPA could be other main key targets of the pharmacological action of kahweol on endothelial cells.