They then examined genetic variants throughout the human genome for their effects
on gene expression in these two representative populations of immune cells.
Our computational biology research programme
focuses on gene expression regulation and the mechanisms by which it can be disrupted in human diseases such as cancer.
A fun, engaging and competitive class quiz, in which teams of students (2 - 3 ideal) work through a set of questions assessing their
knowledge on gene expression.
This indicates that the loops may remain constant during a cell's differentiation, although they may switch their contents, and therefore their
effect on gene expression.
Biomolecular model
based on the gene expression data analyses support the reduction of glucose molecules (blue gradient) and acid buildup (gold gradient) proposed to occur in the boundary layer around the cell.
The project was based
on gene expression data from the modENCODE project, which aims to provide the scientific community with a comprehensive encyclopedia of functional elements of the genome of model organisms.
Based
on gene expression studies of fat tissue conducted at the USDA HNRCA, the Tufts University researchers initiated studies of the role of FAT10 in adipose tissue and metabolism.
We can now explain observed relationships between genotype and disease by looking at the effects of the genotypes that lead to higher risk of the disease
on gene expression levels in disease - specific tissues, including brain.»
We are examining the effect of a maximal exercise stress
test on gene expression, metabolism, inflammatory markers, and cytokine levels in ME / CFS patients and healthy controls.
At the same time, if screening reveals that there is little or no impact
on gene expression from a particular chemical, why not pursue that one for commercial development?»
After graduating from the University of Bristol with a degree in biochemistry, Mills obtained a Ph.D. in biochemistry in 1984 from the University of Kent, both in the United Kingdom, researching the effect of
xenobiotics on gene expression in the liver.
Delving into imprinting is also yielding insights into the scaffolding of the genome, and the ways in which parents put a
stamp on gene expression, influencing health and disease in their children.
Jennings» presentation on Jan. 7 will
center on the gene expression that occurs during this process and if there are genes responsible for starting or stopping the procedure.
What's really impressive about Babar's accomplishment is that he did the work for both papers — one on the role of a population of stem cells in lung cancer development (published in Cell) the
other on gene expression in group A Streptococcus (published in PNAS)-- as a participant in summer undergraduate research programs.
A new study is the first of its kind to show the effects of eating versus
fasting on gene expression in adipose (fat) tissue in response to exercise.
Depending on the tissue type and what jobs that tissue is doing, distinct portions of DNA are unspooled to become available for activity through a structure called open chromatin, said Gregory Crawford, an associate professor of pediatrics and
expert on gene expression.
The two breeds allow scientists to study the impact of drug use and
addiction on gene expression and epigenetics in the nucleus accumbens — the brain's «pleasure center,» where response to drugs like cocaine occurs.
Despite their tiny size — less than 0.2 % the length of the average gene — miRNAs exert a powerful amount of
control on gene expression (ScienceNOW, 19 January 2005).
The researchers hope that these assays will be used by many laboratories that are studying the events associated with early embryonic development and the effect of repeat length and methylation
status on gene expression and differentiation.
In this study, the authors assessed the impact of SNPs, inherited copy number variants (CNVs), and acquired copy number alterations (CNAs)
on the gene expression landscape.
Effect of retinoic
acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16.
Garcia - Ojalvo expressed surprise that a network based
only on gene expression data could predict, with relative accuracy, the effect of multiple genetic interactions.
While previous studies have focused
primarily on gene expression levels and alternative splicing patterns, an important aspect of the transcriptome, RNA editing, has been largely neglected.
These
findings on gene expression in single embryonic stem cells are in concert with recent studies of early mammalian development, which reveal molecular heterogeneity and a stochasticity of gene expression in blastomeres.