Sentences with phrase «on the cell surface»
They receive signals from outside the cell via partner receptors on the cell surface, and G - proteins help deliver those signals to their proper destinations within the cell.
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When applied to neurons in cell culture, the antibody locked onto a protein on the cell surface.
The group was then able to sort the cells using markers expressed on the cell surface, to help pull out successfully edited cells for research, and eventually for therapeutic use.
Various receptors which can either activate or inhibit the cell have been identified on cell surface.
«Changes to the sugar composition on the cell surface could alter physically how receptors are organized,» he said.
And even when a growth factor sends its signal to grow by attaching to receptors on the cell surface, a cell must decide whether it has sufficient nutrients to obey.
The heme - bound HasA protein transfers heme via receptor proteins on the cell surface of the bacterium, P. aeruginosa.
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A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.
To identify which structure on the cell surface helped it enter the cell, Raines screened 264 structures using a specially designed chip.
In particular, it has evolved to show itself three to nine months after infection, allowing its own destruction by displaying antigens on its cell surfaces so the dog's immune system can destroy it.
The good news about the complex interconnectivity is that the scientists also were able to find a potential future point of intervention: When they gave a drug that increased AMPA receptor expression on the cell surface, the spines assumed a more healthy, mature state.
They might also come up with a way to select the right cells out of a mixed population; Anand Swaroop, an ophthalmology researcher at the University of Michigan at Ann Arbor, is working on a way to identify and weed out the photoreceptor cells by focusing on proteins present on cell surfaces.
This antibody activates an integrin on the cell surface of basal progenitors and thus stimulates their proliferation,» explains Denise Stenzel, who headed the experiments.
It then travels down the respiratory tract and binds to epithelial cells lining the lung airways via specific molecules on the cell surface.
«We have shown in this proof - of - concept study that PSMA could serve as a biomarker for MR - based molecular imaging due to its high concentration within target cells, limited expression within non-targeted tissues and accessibility on the cell surface,» said Sangeeta Ray, Ph.D., principal investigator for the study and assistant professor in the Russell H. Morgan Department of Radiology and Radiological Science at the Johns Hopkins Medical Institutions in Baltimore, Md..
WtCXCR4 was detected equally by both antibodies on the cell surface (middle panel, top row) and intracellularly (middle panel, lower row).
These drugs also bind to receptors on the cell surface for adrenalin, counteracting its effect, including its influence on memory formation, it is thought.
Instead they identified a third way: IL - 6 can also be displayed on the cell surface of dendritic cells and thus be directly presented to T cells.
Whitings occur when the cyanobacteria fix atmospheric CO2 through the formation of CaCO3 on their cell surfaces which leads to precipitation to the ocean floor and subsequent entombment in mud.
Here, cells expressing the interacting domains of v - and t - SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes.
One of the genes they focused on was SCARB1, which encodes for Scavenger Receptor B1 (SR - B1), the major receptor for HDL on cell surfaces.
Researchers found that in N. gonorrhoeae, BamE is exposed on the cell surface but is not essential for cell viability.
Researchers already knew that there was a time lag of between 1 and 3 hours between the synthesis of Class II molecules within the APC and their appearance on the cell surface, combined with antigen.
Measuring changes in a voltage bias applied to the saline reveals how close the capillary tube is to the cell, allowing researchers to scan subtle structures on the cell surface without disrupting them.
Cadherin - 22 is located on cell surfaces, allowing hypoxic cancer cells to stick together and migrate collectively as a group, said Uniacke.
In addition to regulating newly synthesized apCAM, serotonin also altered the amount of preexisting apCAM on the cell surface of the presynaptic sensory neurons.
The impulses cause glutamate (one of the brain's main neurotransmitters) to pop out of one nerve cell and travel across the synapse to activate the next by binding to its receptors, chemically active signaling stations on the cell surface.
(Right) In a liver with HCC, AIM accumulates on the cell surface, resulting in the activation of the complement cascade and inducing necrotic cell death.
The team used patterned photoactivation non-linear SIM to produce videos showing structural proteins break down and reassemble themselves as cells move and change shape, as well as the dynamics of tiny pits on cell surfaces called caveolae.
Monoclonal antibodies are engineered in the laboratory to recognize and attach to specific markers carried on the cell surface.
When a protein is more abundant on the cell surface of tumour cells, the immune system has already been sensitised and will react.»
The team chose integrin receptors that control a variety of functions on the cell surface as a target for their peptides.
Arrows point to «envelopes» of the virus on the cell surfaces.
These results show that in non-transformed cells, S1P induces a rearrangement of the actin cytoskeleton and stimulates proteolytic activity on cell surfaces.
The pathway increases the activation of HIF - 1a (hypoxia inducible factor 1 alpha) and produces more glucose transporters on the cell surface — both key changes that promote glycolysis in cancer cells.
Based on cell surface markers known as CD4 and CD8, T cells generally fall into two broad categories: CD4 — positive helper T cells, which ¬ help activate other immune cells and CD8 - positive cytotoxic T cells, which kill cells that are cancerous or infected with viruses.
miR - 34a is greatly reduced in prostate cancer cells that express high levels of CD44 on the cell surface.
It's also been postulated that the leptin receptor binds to a leptin co-receptor on the cell surface.
Like in the Wnt signaling pathway, ligands bind to the EGFR on the cell surface and initiate a cascade of events in the cell that in this case lead to regulation of genes that control cell cycle progression.
The model predicted that the time scales of receptor (de) activation kinetics on the cell surface and the interior compartments were comparable.
This approach is considered «passive,» as nanoparticles do not use ligands targeting specific epitopes on the cell surfaces.
A team there, led by stem - cell pioneer Irving Weissman, MD, demonstrated that many aging cells, and most cancer cells, display a protein called CD47 on the cell surface.
When α or β secretase cleave APP on the cell surface, the N - term mCherry containing domain is released into the medium and the 1:1 fluorescence intensity ratio between the red and green channels is lost.
ABCA1 mediates unfolding of apoAI N - terminus on the cell surface prior to lipidation and release of nascent HDL.
Multiple round bumps on cell surface How Grindr is helping stop the HIV epidemic Education about PrEP and access to treatment for LGBTQ refugees are among its priorities
Multiple round bumps on cell surface Muluba Habanyama was born HIV - positive.