Sentences with phrase «particular cell type»

While the genetic code carried in our DNA provides instructions for cells to manufacture specific proteins, it is a second code that determines which genes are in fact activated in particular cell types.

However, it is difficult to conclude from mixed tissue samples which genes are expressed by particular cell types.

In each case there is interest in obtaining comprehensive, accurate data for particular cell types and in identifying patterns of variation within the data.

Recent theorizing within this tradition suggests that these shifts may be manifested in changes in the relative frequency of particular cell types in blood (Irwin and Cole, 2011) as well as in the epigenetic programming and gene expression of such cells (Miller et al., 2011a).

As they move up the hair follicle they begin to differentiate into particular cell types.

Early in cerebellar development, particular cell types come to be distributed unevenly from top to bottom, creating a dorsal - ventral separation.

«There is a lot of excitement in stem cell biology these days about the possibility of rationally and efficiently generating particular cell types from different stem cells for therapeutic purposes,» he said.

«Targeting the enhancer allows us to study particular cell types in a highly specific way,» says Thomas.

With this in mind, the researchers switched off expression of the mouse Smc3 gene, which encodes part of the cohesin complex, in particular cell types to assess its function.

«For that, we plan to attach antibodies to the surface of the nanoparticles so they will be attracted to particular cell types, and we will evaluate these modified particles in more realistic biological settings.»

«Targeting something that is fundamental and not just a peculiarity of a particular cell type holds greater promise.»

Previous studies have demonstrated that particular cell types, such as those that constitute the retina or cornea, can be created in the laboratory from pluripotent stem cells.

For example, one thing that we are doing is to try to differentiate individual pluripotent stem cells into a particular cell type with a shotgun approach.

We know exactly which cell types are affected, and so we really need to figure out ways to monitor and treat those particular cell types.

These specialised processes involve proteins that are mainly expressed in this particular cell type throughout the body, which are often modulated in vascular disease.

Additionaly, cDNAs can not be used to study in cis regulation and also suffer from an inability to easily deliver the appropriate isoform (s) of a given gene, as, many times, the isoform (s) common to a particular cell type are unknown or not readily available.

By counting the number of enterocytes along the a / p axis, bands of GFP expression were approximately mapped to subregions (Figure 1F — G, dashed lines) in each particular cell type (Figure 1 — figure supplement 2).