Sentences with phrase «pharmacokinetic profile»
The phrase "pharmacokinetic profile" refers to how a drug moves through the body. It includes how the body absorbs, distributes, metabolizes, and eliminates the drug over time. Full definition
Since it is plausible that the unfavorable pharmacokinetic profile of 182a is due to a rapid oxidative metabolism, a series of derivatives functionalized with electron deficient moieties on the terminal aromatic ring were synthesized.
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Antagonist antibody against human TIGIT that demonstrates a classical human IgG pharmacokinetics profile.
In this study, NPT088 was safe and well - tolerated at multiple dose levels, with a suitable pharmacokinetic profile.
Methylxanthine, green tea, theophylline, and then dark chocolate like theobromine and you get, therefore, three very different pharmacokinetic profiles, meaning for those people who don't know the term, the rate at which those peak in your blood plasma.
Proposed mechanisms of action for each drug, and known pharmacokinetic profiles in dogs are discussed.
Pharmacokinetic profile of J147 in mice.
Human Anti-TIGIT Antibody (EOS884448): Antagonist antibody against human TIGIT that demonstrates a classical human IgG pharmacokinetics profile.
«This is exactly the pharmacokinetic profile produced by lithium salicylate in our study,» said senior author Doug Shytle, PhD, also of the Center of Excellence for Aging and Brain Repair at USF Health.
Studies in humans will be needed to confirm safety and demonstrate that the pharmacokinetic profile observed in rats is similarly observed in humans.»
According to Tomas Cihlar, Ph.D., of Gilead Sciences, the company is currently conducting phase I clinical studies of the compound in healthy human volunteers to establish the safety and pharmacokinetic profile.
The Phase 1 study of ISIS - SMNRx is a single - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 14 who are medically stable.
On the other hand, we design drug conjugates to improve their pharmacokinetic profile and therapeutic efficacy.
Furthermore, in order to optimize the pharmacokinetic profile and to improve CXCR4 binding affinity of this class of molecules, dual pyrimidinyl compounds, substituted with different functional groups such as methoxy and morpholine, were synthesized (compounds 194 - 200).
(A) The pharmacokinetic profile of J147 in mice was done by Pharmaron (Louisville, KY, USA).
EOS884448 demonstrates classical human IgG pharmacokinetics profile and a good developability profile.
The platform provides small molecule screening, hit optimization chemistry and pharmacokinetic profiling.
The Phase 1b / 2a study of ISIS - SMNRx is a multiple - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 15 who are medically stable.
It achieves this by enhancing the pharmacokinetic profiles of proven drugs to create novel therapeutics for use alone and in fixed - dose combination products.
This study aims to describe the pharmacokinetic profile of vinblastine in cats and to identify which characteristics or traits that can vary from one cat to another (e.g., age, kidney function, liver function) influence how vinblastine is distributed and eliminated in cats.