Sentences with phrase «phenotypic effects»
The phrase "phenotypic effects" refers to the visible or measurable characteristics of an organism that result from its genetic makeup and the environment it interacts with. It is basically describing the observable traits or features of an organism, such as its appearance, behavior, or physical attributes. Full definition
The alternative model is that mutations of large phenotypic effect underlie most of these traits in dogs and that the same variants have been transferred to a wide diversity of dog breeds leading to phenotypic diversity from a narrow genetic base [5], [8], [12].
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It requires some kind of functional validation, an assay that demonstrates how genetic differences have a measurable phenotypic effect that makes sense for the disease.
The largest numbers of variants identified by genome - wide association are copy - number changes, which have a greater phenotypic effect than do single nucleotide polymorphisms.
«They are the first direct demonstration of use of genome editing to correct point mutations in two diseases with real phenotypic effect.»
Near - isogenic lines for measuring phenotypic effects of DIMBOA - Glc methyltransferase activity in maize
«These genes seem to have relatively large phenotypic effects.»
Here, the authors have done the difficult and time - consuming work of (1) exhaustive sequencing to identify the possible functional variants, and (2) in vivo functional assays to prove that the implicated variants have a phenotypic effect.
You don't know that your lead SNP is functional, or that the nearest neighboring gene provides the mechanism of phenotypic effect.
This study is the first to investigate the phenotypic effects of the HAT activator CTPB, and to demonstrate that p300 / CBP HAT activation has neurotrophic effects in a cellular model of PD.
To positional clone this major sex - specific wing QTL and to more precisely describe its phenotypic effects we (a) reduced the size of the introgressed sequence flanking the ws1 locus to a 40kb segment (see fine - scale mapping and cloning below) and (b) backcrossed the introgressed ws1g segment into a standard N. vitripennis strain (AsymCX) genetic background for > 10 generations.